Aetiology, diagnosis, investigation, and management of the cardiomyopathies

Oakley, Celia M.

doi:10.1136/bmj.315.7121.1520

Cited by 9 publications

(2 citation statements)

References 26 publications

(26 reference statements)

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“…Dilated cardiomyopathy (DCM), a progressive disease of heart muscle, is a common cause of heart failure and the most frequent cause of heart transplantation . Cell therapy with mesenchymal stem cells (MSCs) represents a promising approach for alleviating cardiovascular injury and promoting tissue regeneration and are under active investigation as a potential therapy for DCM .…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of intramyocardial mesenchymal stem cells and VEGF₁₆₅ plasmid injection in rats with furazolidone induced dilated cardiomyopathy

Fang

Zhu

et al. 2015

J Cellular Molecular Medi

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To explore the impact of myocardial injection of mesenchymal stem cells (MSCs) and specific recombinant human VEGF165 (hVEGF165) plasmid on collagen remodelling in rats with furazolidone induced dilated cardiomyopathy (DCM). DCM was induced by furazolidone (0.3 mg/bodyweight (g)/day per gavage for 8 weeks). Rats were then divided into four groups: (i) PBS group (n = 18): rats received equal volume myocardial PBS injection; (ii) MSCs group (n = 17): 100 μl culture medium containing 105 MSCs were injected into four sites of left ventricular free wall (25 μl per site); (iii) GENE group (n = 18): pCMVen-MLC2v-EGFP-VEGF165 plasmid [5 × 109 pfu (0.2 ml)] were injected into four sites of left ventricular free wall (0.05 ml per site)] and (iv) MSCs+GENE group (n = 17): rats received both myocardial MSCs and pCMVen-MLC2v-EGFP-VEGF165 plasmid injections. After 4 weeks, cardiac function was evaluated by echocardiography. Myocardial mRNA expressions of type I, type III collagen and transforming growth factor (TGF)-β1 were detected by RT-PCR. The protein expression of hVEGF165 was determined by Western blot. Myocardial protein expression of hVEGF165 was demonstrated in GENE and MSCs+GENE groups. Cardiac function was improved in MSCs, GENE and MSCs+GENE groups. Collagen volume fraction was significantly reduced and myocardial TGF-β1 mRNA expression significantly down-regulated in both GENE and MSCs+GENE groups, collagen type I/III ratio reduction was more significant in MSCs+GENE group than in MSCs or GENE group. Myocardial MSCs and hVEGF165 plasmid injection improves cardiac function possibly through down-regulating myocardial TGF-β1 expression and reducing the type I/III collagen ratio in this DCM rat model.

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Section: Introductionmentioning

confidence: 99%

Beneficial effects of intramyocardial mesenchymal stem cells and VEGF₁₆₅ plasmid injection in rats with furazolidone induced dilated cardiomyopathy

Fang

Zhu

et al. 2015

J Cellular Molecular Medi

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“…Sumber: Oakley, 1997. 20 Mayoritas pasien dengan miokarditis akan sembuh tanpa kecacatan, namun pada sepertiganya akan mengalami disfungsi ventrikel. 19,21 Sekitar 25% kelompok ini mengalami perburukan sehingga membutuhkan transplantasi atau meninggal.…”

Section: Patogenesis Kardiomiopatiunclassified

Kardiomiopati Pada Infeksi Hiv

Rampengan

2013

JBM

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Heart muscle involvement associated with human immunodeficiency virus (HIV) infection may be seen as myocarditis, dilated cardiomyopathy, or as an isolated left or right ventricular dysfunction. Histopathological and ultra structural findings with different degrees of cardiac-chamber dilation have been described, and important roles of cytokines (tumor necrosis factor-alpha, interleukin-1, and interleukin-6) have been suggested. HIV infection is an important cause of dilated cardiomyopathy, with a prevalence of 3.6% among cardiomyopathy patients that live longer. HIV patients with dilated cardiomyopathy have a much worse prognosis than those with idiopathic dilated cardiomyopathy (hazard ratio of death 4.0). HIV related myocardial dysfunction may easily be overlooked due to attributing symptoms such as breathlessness, fatigue, respiratory diseases, or anaemia. The diagnosis is readily made by echocardiography which can show dilatation or impaired contractility, or both of either or both ventricles. Isolated right ventricular dysfunction can be caused by cardiomyopathy, pulmonary hypertension secondary to repeated respiratory infections, thromboembolic diseases, or recurrent pulmonary emboli from intravenous debris acquired through drug abuse. Endomyocardial biopsy in patients with heart failures associated with HIV infection has been performed in several centers, and has identified myocarditis caused by potentially treatable infections due to organisms such as toxoplasma gondii. Keywords: Cardiomyopathy, HIV infection, myocarditis, management. Abstrak: Keterlibatan kerusakan jantung pada pasien human immunodeficiency virus (HIV) biasanya dalam bentuk miokarditis, kardiomiopati dilatasi, ataupun disfungsi ventrikel kiri atau kanan terisolasi. Penemuan histopatologik dan ultrastruktur menunjukkan perbedaan derajat dilatasi ruang-ruang jantung dipengaruhi oleh peranan beberapa jenis sitokin (tumor necrosis factor-alpha, interleukin-1 dan interleukin-6). Infeksi HIV merupakan penyebab utama terjadinya kardiomiopati dilatasi dengan prevalensi 3,6% dari antara penderita kardiomiopati yang hidup lama. Infeksi HIV dan kardiomiopati dilatasi memiliki prognosis yang jauh lebih buruk dibandingkan dengan penderita kardiomiopati dilatasi yang idiopatik. Disfungsi miokard dalam kaitannya dengan HIV lebih mudah diidentifikasi karena adanya gejala yang jelas seperti sesak napas, mudah capek, penyakit saluran napas ataupun anemia. Hal tersebut diatas menyingkirkan kemungkinan akibat terapi paliatif dari pasien HIV. Diagnosis pasti dilakukan dengan pemeriksaan ekokardiografi, dimana terlihat dilatasi ataupun perburukan kontraktilitas jantung maupun akibat dari keduanya, atau terjadi pada kedua ventrikel. Disfungsi ventrikel kanan terisolasi dapat diakibatkan karena kardiomiopati, juga hipertensi pulmonal sekunder oleh karena infeksi saluran napas berulang, penyakit tromboemboli maupun emboli paru berulang dari debris intravena pada pecandu narkoba. Di beberapa pusat jantung telah dilakukan biopsi endomiokard pada pasien gagal jantung dengan infeksi HIV, dan diidentifikasi penyebab tersering yang dapat diobati adalah miokarditis dengan organisme seperti toxoplasma gondii. Kata Kunci: Kardiomiopati, infeksi HIV, miokarditis, tatalaksana.

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Multisite Pacing for Heart Failure: From Electrophysiology to Hemodynamics

Padeletti¹,

Sabini²,

Guerra³

et al. 2004

The Fifth Decade of Cardiac Pacing

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Aetiology, diagnosis, investigation, and management of the cardiomyopathies

Cited by 9 publications

References 26 publications

Beneficial effects of intramyocardial mesenchymal stem cells and VEGF₁₆₅ plasmid injection in rats with furazolidone induced dilated cardiomyopathy

Beneficial effects of intramyocardial mesenchymal stem cells and VEGF₁₆₅ plasmid injection in rats with furazolidone induced dilated cardiomyopathy

Kardiomiopati Pada Infeksi Hiv

Multisite Pacing for Heart Failure: From Electrophysiology to Hemodynamics

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Aetiology, diagnosis, investigation, and management of the cardiomyopathies

Cited by 9 publications

References 26 publications

Beneficial effects of intramyocardial mesenchymal stem cells and VEGF165 plasmid injection in rats with furazolidone induced dilated cardiomyopathy

Beneficial effects of intramyocardial mesenchymal stem cells and VEGF165 plasmid injection in rats with furazolidone induced dilated cardiomyopathy

Kardiomiopati Pada Infeksi Hiv

Multisite Pacing for Heart Failure: From Electrophysiology to Hemodynamics

Contact Info

Product

Resources

About

Beneficial effects of intramyocardial mesenchymal stem cells and VEGF₁₆₅ plasmid injection in rats with furazolidone induced dilated cardiomyopathy

Beneficial effects of intramyocardial mesenchymal stem cells and VEGF₁₆₅ plasmid injection in rats with furazolidone induced dilated cardiomyopathy