Aetiology and risk factors for neonatal sepsis at the Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria

Shobowale, Emmanuel Olushola; Ogunsola, F.T.; Oduyebo, O.O.; Ezeaka, Chinyere

doi:10.7196/sajch.2016.v10i3.965

Cited by 14 publications

(28 citation statements)

References 11 publications

(15 reference statements)

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“…Neonates delivered at the health center were three times more likely to develop sepsis as compared to neonates delivered at hospitals. This nding is in agreement with ndings from studies in Nigeria (21) and Ethiopia (3,19). This might be due to the reason that neonates who were delivered at health center may be less likely to be screened based on a risk approach and treated with intra-partum antibiotic prophylaxis (38).…”

Section: Discussionsupporting

confidence: 90%

“…The possible reason for having similar results might be due to similarities of study population studied in the same area and the period in which the studies were conducted. This nding is, however, much higher than ndings of studies from Uganda(11%) (14), India(32%)(6), Tanzania(31.4%)(2) and Nigeria(34%) (21). This difference might have been contributed by methodological difference and the difference in diagnostic modality to con rm neonatal sepsis.…”

Section: Discussionmentioning

confidence: 67%

“…Residence, ANC, parity, duration of labor, mode of delivery, foul smelling liquor, birth asphyxia, PROM, gestational age, and birth weight were not found to be predictors of neonatal sepsis in this study. This is in against the ndings of studies on risk factors of neonatal sepsis in different parts of the world (3,9,19,21,24,25).…”

Section: Discussionmentioning

confidence: 83%

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Institutional Delivery Predisposes to Neonatal Sepsis and Its Associated Factors Among Neonates Admitted to Neonatal Intensive Care Units in Central Gondar Zone Primary Hospitals, Northwest Ethiopia, 2019.

Agnche¹,

Yeshita

Gonete

2020

Preprint

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Background: Neonatal sepsis contributes substantially to neonatal morbidity and mortality and is an ongoing major global public health challenge particularly in developing countries. Studies conducted on proportion and risk factors of neonatal sepsis in Ethiopia are from referral hospital which may not be generalized to primary health care units where a significant proportion of mothers give birth in these health facilities. This study sought to determine the proportion of clinical neonatal sepsis and associated factors in the study areas.Methods: Institutional based cross-sectional study was conducted from March to April 2019, in Amhara regional state, central Gondar zone public primary hospitals in Ethiopia. A total of 352 subjects (mother-neonate pairs ) were selected using systematic random sampling technique and pre-tested and structured questionnaires were used to collect data. Multivariable logistic regression analysis was fitted to identify factors associated with neonatal sepsis. Adjusted Odds Ratio (AOR) with the corresponding 95% confidence Interval (CI) was used to show the strength of associations and variables with p-values of <0.05 were considered as statistically significant.Results: The overall proportion of neonatal sepsis was 64.8 %( 95% CI (59.2, 69.2). Being male neonate(AOR=3.7; 95% CI(1.76,7.89)), history of urinary tract infections during the index pregnancy(AOR =6,26; 95% CI (1.16,33.62)), frequency of per-vaginal examination greater than three during labor and delivery(AOR=6.06; 95% CI((2.45,14.99)), neonatal resuscitation at birth (AOR=6.1; 95% CI (1.71,21.84)), place of delivery at the health center(AOR=3.05; 95% CI(1.19,7.79)), lack of training of health workers on neonatal resuscitation and infection prevention practices (AOR=2.14; 95% CI (1.04,4.44)), late age of neonate at onset of illness(AOR=0.05; 95% CI(0.01, 0.21)) and maternal age of 30-34 years (AOR=0.19; 95% CI(.047, 0.81)) were significantly associated with neonatal sepsis.Conclusion: The proportion of neonatal sepsis is high. Maternal, neonatal and health service related factors were identified for neonatal sepsis. Therefore; training of health workers, provision of health care services as per standards and monitoring and evaluation of obstetrical/neonatal cares during labor and delivery are mandatory.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 67%

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Institutional Delivery Predisposes to Neonatal Sepsis and Its Associated Factors Among Neonates Admitted to Neonatal Intensive Care Units in Central Gondar Zone Primary Hospitals, Northwest Ethiopia, 2019.

Agnche¹,

Yeshita

Gonete

2020

Preprint

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“… 46 However, contrasting findings were observed in earlier studies conducted in different parts of the world. 9 44 47 48 49 Early rupture of membrane and prolonged labor increases the chance of ascending microorganisms from the birth canal into the amniotic sac and fetal compromise as well as asphyxia which frequently leads to sepsis in the neonatal period. 50 This finding could serve as justification for prophylactic antibiotic therapy for neonates born to mothers with a history of PROM during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with neonatal sepsis in a tertiary hospital, North West Nigeria

et al. 2020

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Context: Neonatal sepsis is an important cause of morbidity and mortality of newborns, especially in developing countries. Aims: Our study determined the prevalence of neonatal sepsis and its predisposing factors among neonates admitted in Ahmadu Bello University Teaching Hospital (ABUTH). Settings and Design: This was a cross-sectional descriptive study conducted in ABUTH. Subjects and Methods: The data were abstracted from the case notes of neonates admitted from May 2017 to May 2018. A pretested pro forma was used to abstract the data. Statistical Analysis Used: Odds ratios and multivariate logistic regression were used to determine the factors associated with neonatal sepsis among the study population. Results: The prevalence of neonatal sepsis was 37.6%. Escherichia coli was the most commonly isolated organism. Neonates 0–7 days of age were 2.8 times less likely to develop neonatal sepsis than older neonates. Babies born with an Apgar score of <6 within the 1 st min were 2.4 times more likely to develop neonatal sepsis than those whose Apgar score was higher. Neonates of mothers who had urinary tract infection during pregnancy were 2.3 times more likely to have had sepsis and those whose mothers had premature rupture of membranes were 4.6 times more likely. Conclusions: The prevalence of neonatal sepsis was high among the neonates studied. Neonatal and maternal factors were associated with sepsis in the neonates. These findings provide guidelines for the selection of empirical antimicrobial agents in the study site and suggest that a continued periodic evaluation is needed to anticipate the development of neonatal sepsis among neonates admitted.

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“…All studies related to neonates either admitted in the hospital or community-based studies within the neonatal period of life in African, Asian and Latin America was included in the study. These developing countries were Nigeria [7, 14, 15, 61], Nepal [16, 17, 18], Tanzania [19], Ethiopia [9, 10, 12, 20, 21], Egypt [22, 23], Bangladesh [24], Sudan [25, 26], Indonesia [27], Zambia [28], India [29, 30, 31, 32, 33] Sri Lanka [34], Uganda [35], Haiti [36], Kenya [37], Ghana [38], South Africa [8], Cameroon [39], Brazil [40], Mexico [41], Jamaica [42] and Nepal [17, 18]. Publication year: All articles published from 2005 to 2018 are used for systematic review and meta-analysis.Design: All observational studies which assessed the neonatal sepsis in developing countries are included in the study.Publication status: All published literature were included in the study.Language: Only articles published literature reported in the English language were included.…”

Section: Methodsmentioning

confidence: 99%

Unfinished agenda of the neonates in developing countries: magnitude of neonatal sepsis: systematic review and meta-analysis

Amare

Mela

Dessie

2019

Heliyon

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PurposeNeonatal sepsis is the major cause of mortality and morbidity globally, particularly in developing countries. Despite studies revealed the extent of neonatal sepsis in developing countries, the findings were inconclusive. Therefore, the main aim of this study was to determine the pooled prevalence of neonatal sepsis in developing countries.MethodsWe used a systematic review and Meta-analysis study method. The reviewed studies were accessed through an electronic web-based search strategy from the electronic database (PUBMED), advanced google scholar, different journal sites. The data extraction was done by two researchers using a data extraction table and the disparity between data extractors was resolved by the third researcher. The analysis was done using STATA version 11. The I2 test was used to assess heterogeneity across studies. The Funnel plot, Begg's test, and Egger's test were used to check for publication bias. The random-effect model was used to determine the pooled effect size. All studies related to neonatal sepsis which fulfill the inclusion criteria were considered into this study. The quality of each study was checked using the Newcastle-Ottawa Scale and studies graded low score were excluded from the study.ResultsAt the end, 36 articles fit with our study objectives. Studies conducted in Ethiopia were significant the source of heterogeneity of the study with a coefficient = 90, P-value = 0.025. The overall pooled prevalence of the study was 29.92%. The limitations of this study would be the authors were only used articles reported in the English language, and publication bias.ConclusionThe pooled prevalence of neonatal sepsis was found to be high which accounted for a third of the neonates. Despite countries have established possible prevention and treatment mechanisms, neonatal sepsis is the major public health problem in lower and middle-income countries till now.

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Aetiology and risk factors for neonatal sepsis at the Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria

Abstract: This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.

Cited by 14 publications

References 11 publications

Institutional Delivery Predisposes to Neonatal Sepsis and Its Associated Factors Among Neonates Admitted to Neonatal Intensive Care Units in Central Gondar Zone Primary Hospitals, Northwest Ethiopia, 2019.

Institutional Delivery Predisposes to Neonatal Sepsis and Its Associated Factors Among Neonates Admitted to Neonatal Intensive Care Units in Central Gondar Zone Primary Hospitals, Northwest Ethiopia, 2019.

Prevalence and factors associated with neonatal sepsis in a tertiary hospital, North West Nigeria

Unfinished agenda of the neonates in developing countries: magnitude of neonatal sepsis: systematic review and meta-analysis

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