Aetiological Factors in Mouth Cancer

Wynder, Ernest L.; Bross, Irwin D. J.

doi:10.1136/bmj.1.5028.1137

Cited by 81 publications

(15 citation statements)

References 7 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Wynder and Bross (1957) reported that drinkers of predominantly whiskey had a higher relative risk for oral cancer than drinkers of predominantly beer or wine. They did not, however, adjust for smoking.…”

Section: Discussionmentioning

confidence: 99%

“…If this were the case, it would suggest that some ingredient other than ethanol in certain alcoholic beverages contributes to oral cancer risk or that some alcoholic beverages might contain protective components. Several studies have reported a greater risk of upper aerodigestive tract cancers associated with a specific type of alcoholic beverage (Williams and Horm, 1977;Wynder and Bross, 1957;Tuyns et al, 1977Tuyns et al, , 1979LeClerc et al, 1987;Mashberg et al, 1981) whereas others have found no differences between different types of beverage (Feldman and Kissin, 1979;De Stefani et al, 1987).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Type of alcoholic beverage and oral cancer

Kabat

Wynder

1989

Intl Journal of Cancer

View full text Add to dashboard Cite

The effect on oral cancer risk of different types of alcoholic beverage was investigated using data from a hospital-based case-control study. Owing to the small numbers of subjects drinking one beverage exclusively, it was necessary to classify drinkers as consumers of predominantly beer, wine, or hard liquor (i.e., more than 50% of their whiskey equivalents of alcohol derived from a specific beverage). The number of predominantly wine drinkers was too small to permit analysis. Logistic regression was used to obtain estimates of the risk associated with each predominant beverage, with adjustment for other risk factors and confounding variables. In males, the odds ratio for predominantly beer drinkers increased with increasing level of intake, reaching 4.87 (95% confidence interval: 2.51-9.46) in drinkers of 7+ oz. of whiskey equivalents/day. The odds ratio for predominantly hard liquor drinkers showed a similar increase, reaching 5.74 (95% confidence interval: 2.94-11.22) in predominantly hard liquor drinkers consuming 7+ oz. of whiskey equivalents/day, suggesting that the effect of these 2 major types of alcoholic beverage is of similar magnitude. The trends were less clearcut in women due to small numbers of drinkers.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Type of alcoholic beverage and oral cancer

Kabat

Wynder

1989

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Nevertheless only a minority (10-20%) of heavy drinkers develop such a cancer (Wynder and Bross 1957). Part of the reason may lie in constitutional factors, predisposing some alcoholics to develop upper respiratory/digestive tract cancer.…”

Section: Introductionmentioning

confidence: 99%

Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms

et al. 1997

View full text Add to dashboard Cite

In this study the GSTmu phenotype and ADH genotype at the ADH3 locus were investigated in a group of 39 alcoholic men with upper respiratory/digestive tract cancer: 21 with oropharyngeal cancer and 18 with laryngeal cancer. The results are compared with those of a control group of 37 alcoholic men without alcohol-related medical complications. Of the control subjects, 48% were found to be GSTmu deficient [GSTmu(-)] and 19% carried the ADH(3)1/ADH(3)1 genotype. In the laryngeal cancer patients, a significantly elevated frequency of both the GSTmu(-) (78%) and ADH(3)1/ADH(3)1 genotype (56%) was observed, relative to the control group. On the basis of this result, the risk of laryngeal cancer associated with the GSTmu(-) and ADH(3)1/ADH(3)1 genotypic combination within the population of alcoholics was estimated to be 12.9 with a 95% confidence interval of 1.8-92 (P < 0.01) relative to alcoholic individuals who have GSTmu [GSTmu(+)] and are not ADH(3)1/ADH(3)1. Thus, alcoholics who are GSTmu(-) and ADH(3)1/ADH(3)1 have at least an 80% greater risk of developing laryngeal cancer than alcoholics who are GSTmu(+) and who are not ADH(3)1/ADH(3)1. In addition, the oropharyngeal cancer patients had excess frequencies of both GSTmu(-) (62%) and ADH(3)1/ADH(3)1 (43%) relative to the control group, but these excess frequencies were not statistically significant. The GSTmu(-) and ADH(3)1/ADH(3)1 genotypic combination may be a constitutional risk factor for laryngeal cancer among alcoholics.

show abstract

“…In no i'hstance, however, has the precise causative agent or mechanism been identifi ed. Cancer of the mouth, larynx, and esophagus in women with Plummer Vinson syndrome originally noted in 1936 (164) is documented again in Sweden (160,162). Cancer of the liver was found in 82 of 2402 patients with cirrhosis autopsied at the Boston City Hospital (165).…”

Section: Etiology Of Cancer In Manmentioning

confidence: 97%

“…For example, in one study of mortality in England, the death rate from lung cancer for heavy smokers was 20 times that for 110nsmokers (159). Tobacco seems similarly related to carcinoma of the larynx (160), bladder (161), and mouth (162). The whole problem of cancer of the lung, larynx, and urinary tract is summarized by Kenna way (163).…”

Section: Etiology Of Cancer In Manmentioning

confidence: 99%

Neoplastic Diseases (Cancer)

Cg¹

1958

Annu. Rev. Med.

View full text Add to dashboard Cite

This review of neoplastic diseases is an attempt to describe developments of the past two years. The reviewer has chosen to discuss only cancer in man with the specific purpose of presenting some aspects of the natural history of cancer. Extrapolation to man of the results of recent in vitro and animal studies has been deliberately avoided, with one major exception. GENERAL EFFECTS, OF TUMORS UPON THE PATIENT J The survey of literature pertaining to this review was concluded on JUly 1, 1957. Annu. Rev. Med. 1958.9:287-302. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/02/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS Annu. Rev. Med. 1958.9:287-302. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/02/15. For personal use only. Annu. Rev. Med. 1958.9:287-302. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/02/15. For personal use only.

show abstract

Aetiological Factors in Mouth Cancer

Cited by 81 publications

References 7 publications

Type of alcoholic beverage and oral cancer

Type of alcoholic beverage and oral cancer

Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms

Neoplastic Diseases (Cancer)

Contact Info

Product

Resources

About