Aetiological aspects of the globus symptom

Mair, Iws; Schröder, K. E.; B, Modalsli; Mäurer, H.

doi:10.1017/s002221510007969x

Cited by 48 publications

(22 citation statements)

References 22 publications

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“…The results of the response to treatment are difficult to interpret, because there is a large placebo effect induced by the reassurance provided by the thorough investigation undertaken during the study. Previous studies have demonstrated that globus pharyngis patients may respond to antireflux medication whether or not they have reflux 4,13 . In addition, the natural history of globus pharyngis is to show resolution in 25% of cases and improvement in 35% on long‐term follow‐up (mean follow‐up, 27 months) after diagnosis and reassurance 14 …”

Section: Discussioncontrasting

confidence: 81%

“…Subsequent studies in the 1970s and 1980s appeared to support the theory that there was an association between gastroesophageal reflux and globus pharyngis symptoms, 2,3 with reflux rates of 47% 4 and even 90% 5 in globus pharyngis subjects recorded. These studies, however, lacked controls and had to rely on barium studies to demonstrate hiatus hernia, reflux, or disordered esophageal motility after ingestion of a hydrochloric acid‐barium mixture.…”

Section: Introductionmentioning

confidence: 99%

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Gastroesophageal Reflux, Motility Disorders, and Psychological Profiles in the Etiology of Globus Pharyngis

et al. 1997

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The aim of this study was to investigate the origin of globus pharyngis with particular reference to esophageal disorders such as gastroesophageal reflux disease (GERD), motility disorders, structural abnormalities, other gastrointestinal tract diseases, and psychological profile. Previous studies on this subject using 24-hour pH monitoring give conflicting results and are hampered by the high background prevalence of asymptomatic GERD in the normal Western population. The local Chinese population is known to have a very low background level of GERD and therefore is an ideal study population. Twenty-six patients with globus pharyngis underwent 24-hour ambulatory pH monitoring, esophageal manometry, and esophagogastroduodenoscopy with lower esophageal biopsy. A control group of 20 patients presenting with non-ulcer dyspepsia was similarly investigated. Personality profiles of the globus pharyngis subjects and an appropriate control group were assessed. Eight of the globus pharyngis group (30.7%) had evidence of GERD, whereas only one of the controls (5%) demonstrated GERD on 24-hour esophageal pH monitoring (P < 0.05). The manometric and personality profile studies did not show significant differences between study and control groups. We concluded that the finding of GERD in patients with globus pharyngis is not a coincidental finding but that there is a true association between GERD and globus pharyngis.

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Section: Discussioncontrasting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Gastroesophageal Reflux, Motility Disorders, and Psychological Profiles in the Etiology of Globus Pharyngis

et al. 1997

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“…Delahunty and Ardan [5] found that many of their globus patients were suffering from reflux esophagitis and could be cured with an antacid regimen. However, Mair et al [15] considered that the importance of a hiatal hernia in the etiology of globus was doubtful. However, Mair et al [15] considered that the importance of a hiatal hernia in the etiology of globus was doubtful.…”

Section: Discussionmentioning

confidence: 99%

Globus sensation and gastroesophageal reflux

Chevalier

Brossard

Monnier

2003

Eur Arch Otorhinolaryngol

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Recent studies suggest that gastroesophageal reflux disease (GERD) may be a major cause of globus sensation. However, the incidence and severity of GERD in patients with globus sensation without reflux symptoms are unknown. In order to establish the relationship between globus sensation in the jugular fossa and GERD, 20 patients attending our ear, nose and throat (ENT) outpatient clinic with globus sensation were investigated with 24-h pH monitoring. A four-channel pH catheter was used with the pH electrodes spaced 5 cm apart in order to detect reflux along the whole length of the esophagus. Fifteen patients complained about globus sensation only; five patients complained additionally about classical reflux symptoms. Thirteen patients showed pathologic reflux measurements. Most of the patients had reflux limited to the distal one-third of the esophagus. Patients with pathologic pH measurements were treated with proton pump inhibitors. Ten out of 13 patients improved with treatment. This study suggests that globus may be associated with reflux, and acidity does not have to reach the pharynx to produce globus sensation.

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“…Data for a physiologic explanation of globus sensation have produced conflicting results (Orenstein, Izadnia, & Khan, 1999;Richter & Bradley, 1996;Mair, Schroder, Modalsi, & Maurer, 1974). Herbst (1996) reported that the globus sensation does not signify a psychological disorder, but rather a dysmotility of the upper esophageal or pharangeal muscles.…”

Section: Physical Explanationmentioning

confidence: 99%

Pediatric Gastrointestinal Disorders

2006

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The analysis of the prevalence, clinical manifestations, diagnosis, and treatment of functional gastrointestinal disorders (FGID) in infants was carried out. According to the analysis results the development of FGID in infancy is caused by disorders of motor function and somatic sensitivity of the digestive organs, changes in the secretory and suction functions of this system, largely due to anatomophysiological features of an early age. The peculiarities of posseting, colic, and constipation are considered as the most frequent FGID manifestations in infants. The current approaches to the treatment of the specified manifestations are analyzed, including a number of activities, in particular, psychological preparation of parents, support of breastfeeding, rational nutrition of the mother during breastfeeding, if necessary, the selection of formulas for mixed or artificial feeding, the use of medicines and probiotics. We noted that the high incidence and adverse effects of FGID in children determine the urgency to research on the mechanisms of their development in order to improve preventive and curative interventions. В практику педиатра Выполнен анализ распространенности, клинических проявлений, диагностики и лечения функциональных нару-шений (ФН) желудочно-кишечного тракта (ЖКТ) у детей раннего возраста. Показано, что в основе развития ФН в младенчестве лежат нарушения моторной функции и соматической чувствительности органов пищеварения, изменения секреторной и всасывающей функций этой системы, в значительной мере обусловленные анатомо-физиологическими особенностями раннего возраста. Рассмотрены особенности срыгивания, колик, запоров как наиболее частых проявлений ФН ЖКТ у детей раннего возраста; проанализированы современные подходы к их лечению, включающие ряд мероприятий, в том числе психологическую подготовку родителей, поддержку грудного вскармливания, рациональное питание матери при грудном вскармливании, при необходимости подбор смесей для смешанного или искусственного вскармливания, использование лекарственных средств, применение пробио-тиков. Отмечено, что высокая частота и неблагоприятные последствия ФН ЖКТ у детей определяют актуальность изучения механизмов их развития для совершенствования лечебно-профилактических мероприятий. Ключевые слова: желудочно-кишечный тракт, функциональные заболевания, дисбактериоз, колики, гастроэзофа-геальный рефлюкс. (Для цитирования: Броева М.И., Сурков А.Н., Черников В.В. Современные проблемы диагностики и лечения функциональных заболеваний желудочно-кишечного тракта у детей. Контактная информация: Броева Марика Индикоевна, кандидат медицинских наук, заведующая отделением общей педиатрии ФГАУ «НМИЦ здоровья детей» Минздрава России

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Aetiological aspects of the globus symptom

Cited by 48 publications

References 22 publications

Gastroesophageal Reflux, Motility Disorders, and Psychological Profiles in the Etiology of Globus Pharyngis

Gastroesophageal Reflux, Motility Disorders, and Psychological Profiles in the Etiology of Globus Pharyngis

Globus sensation and gastroesophageal reflux

Pediatric Gastrointestinal Disorders

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