Aesculin offers increased resistance against oxidative stress and protective effects against Aβ-induced neurotoxicity in Caenorhabditis elegans

Wang, Ying; Cheng, Qian; Su, Qina; Yu, Xuesong; Shen, Tianqi; Yang, Xiaoling; Jia, Weizhang

doi:10.1016/j.ejphar.2022.174755

Cited by 7 publications

(4 citation statements)

References 52 publications

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“…Moreover, the extracts themselves may exert anti-oxidant properties to directly scavenging ROS. 19 , 53 Taken together, the results suggested that H. scabra extracts could reduce Aβ oligomeric form and their toxicity, as well as exert anti-oxidant effect to neutralize oxidative stress, thereby improving the overall health span and lifespan of the organism. Therefore, using crude extracts of H. scabra to treat AD seems to be more advantageous than single compound as they may act synergistically to activate several targets to attenuate AD progression.…”

Section: Discussionmentioning

confidence: 90%

Holothuria scabra extracts confer neuroprotective effect in C. elegans model of Alzheimer's disease by attenuating amyloid-β aggregation and toxicity

Kleawyothatis

Jattujan

Chumpoochai

et al. 2023

Journal of Traditional and Complementary Medicine

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Section: Discussionmentioning

confidence: 90%

Holothuria scabra extracts confer neuroprotective effect in C. elegans model of Alzheimer's disease by attenuating amyloid-β aggregation and toxicity

Kleawyothatis

Jattujan

Chumpoochai

et al. 2023

Journal of Traditional and Complementary Medicine

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“…C. elegans assays were first used as a biological model and in environmental and chemical toxicity to obtain data from a whole animal with active digestive, reproductive, sensory, and neuromuscular systems 110 , 111 . Nowadays, this model is used in drug toxicity analysis, such as cisplatin 112 and aesculin, a coumarin compound extracted from TCM Qinpi (Cortex Fraxini) 113 .…”

Section: Application Of Biotechnology In Pharmaceutical Products Anal...mentioning

confidence: 99%

Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses

Chen

Zhang

et al. 2022

Acta Pharmaceutica Sinica B

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“…2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) method was used to test the effect of swertisin on the level of ROS in C. elegans (Wang et al, 2022). The nonfluorescent probe DCFH-DA was oxidized by ROS to a green fluorescent product DCF so that its average fluorescence intensity directly reflected the level of ROS in worms.…”

Section: Reactive Oxygen Species (Ros) Accumulation Assaymentioning

confidence: 99%

“…The accumulation of oxidative damage exceeds the capacity of the antioxidant defense system, and then a condition of oxidative stress will be evoked (Wang et al, 2022). C. elegans has antioxidant stress mechanisms and related genes homologous to mammals and its antioxidative stress ability is well correlated with the prolongation of life span (Hartwig, Heidler, Moch, Daniel, & Wenzel, 2009; Zhang, Jie, Zhang, & Zhao, 2009).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic‐assisted extraction of swertisin from sour Jujube seed and comprehensive revelation of its antioxidant activity

Liu

Zhang

et al. 2022

Journal of Food Biochemistry

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As a typical flavonoid glycoside, swertisin mainly exists in sour Jujube seed. In this study, swertisin was extracted by ultrasound‐assisted extraction method optimized with Box–Behnken design and response surface methodology. The antioxidant effect of swertisin was determined in vitro and in Caenorhabditis elegans (C. elegans). Furthermore, the potential mechanisms of its antioxidant stress were comprehensively evaluated and explored with network pharmacology and molecular docking technology. The results showed obvious scavenging ability of swertisin on free radical and swertisin (50, 250, and 500 μmol/L) significantly enhanced antioxidative enzymes activity (GST‐4, SOD‐3, and GSH‐PX) and reduced the reactive oxygen species and malondialdehyde accumulation in C. elegans, thereby protecting them from oxidative stress (heat stress and hydrogen peroxide). A total of 139 antioxidant targets of swertisin were screened and 70 signal pathways were enriched, including cancer‐related pathways, lipid metabolism, liver injury‐related pathways, acute lung injury, nervous system diseases, etc. This study provides the basis for further investigation on the antioxidant stress mechanism and contributes to the development of relevant drugs from natural products. Practical applications The imbalance between the antioxidant defense system and reactive oxygen species is one of the main causes of neurodegenerative diseases, cardiovascular diseases, cancer, and aging. Therefore, alleviating oxidative stress injury has become a common strategy, which is helpful for the multi‐target treatment of related diseases. The flavonoid of sour Jujube seed possesses potential antioxidant activity with multiple food health effects. From this study results, we optimized ultrasound‐assisted extraction method for extracting the swertisin from sour Jujube seed and supported the use of C. elegans as an in vivo experimental model. We can recommend that the swertisin as a natural ingredient has a positive effect on antioxidation, which provided a scientific basis for treating related diseases through relevant pharmacological mechanisms and making antiaging functional food formula.

show abstract

Aesculin offers increased resistance against oxidative stress and protective effects against Aβ-induced neurotoxicity in Caenorhabditis elegans

Cited by 7 publications

References 52 publications

Holothuria scabra extracts confer neuroprotective effect in C. elegans model of Alzheimer's disease by attenuating amyloid-β aggregation and toxicity

Holothuria scabra extracts confer neuroprotective effect in C. elegans model of Alzheimer's disease by attenuating amyloid-β aggregation and toxicity

Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses

Ultrasonic‐assisted extraction of swertisin from sour Jujube seed and comprehensive revelation of its antioxidant activity

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