Aerosolized plus Intravenous Colistin versus Intravenous Colistin Alone for the Treatment of Ventilator‐Associated Pneumonia: A Matched Case‐Control Study

Abstract

Addition of AS colistin to IV colistin did not provide additional therapeutic benefit to patients with MDR VAP due to gram-negative bacteria.

Carbapenem-resistant Enterobacteriaceae in special populations: Solid organ transplant recipients, stem cell transplant recipients, and patients with hematologic malignancies

“…71 When administered parenterally, the polymyxins poorly penetrate lung tissue, though aerosolized colistin may be used as adjunctive therapy for CRE pneumonia. 72,73 Most CRE isolates maintain susceptibility to tigecycline in vitro, although there are limited data supporting its use as monotherapy. The role of tigecycline in treating urinary tract and bloodstream infections is controversial due to the inability to achieve adequate urine and serum concentrations.…”

Inhaled Colistin Use for Multi-Drug Resistant Gram-Negative Pneumonia in an Immunocompromised Patient: Case Report

“…23 But its polycationic/hydrophilic structure limits its penetration to lung tissue; therefore aerosolized form has been evaluated for generating high drug concentrations at site of infection without increasing the risks of systemic toxicity and resistance against colistin. [15][16][17][18][19] Aerosolized colistin has been found to be successful in the treatment of MDR Pseudomonas related pneumonia in cystic fibrosis patients. 24 Clinical data for patients without cystic fibrosis are derived from uncontrolled small case series, as well as retrospective and non-randomized studies.…”

“…[15][16][17][18][19] There are few observational, retrospective, uncontrolled small case series, including patients with malignancies, about use of combination of inhaled and intravenous colistin for management of hospital acquired pneumonia (HAP) caused by MDR Pseudomonas aeruginosa. 12,14,19,20 Herein, we present a case with lymphoma developed neutropenia and subsequently HAP caused by MDR Pseudomonas aeruginosa, and treated successfully with combined colistin therapy.…”

Efficacy and Safety of Aerosolized Colistin in the Treatment of Ventilator-Associated Pneumonia: A Systematic Review and Meta-analysis

“…총 9개의 문헌 (randomized controlled trial 1개 27) , cohort 5개 [22][23][24][25][26] , case-control 3개 24,28,30) ) 중 8개 문헌에 대해서는 Newcastle-Ottawa Quality Assessment Scale을 1개의 문헌에 대해서는 Cochrane risk-of-bias tool을 사용하여 quality를 평 가하였고 그 결과는 Table 1에 제시하였다. 각 문헌의 quality assessment 결과 한 연구 참고문헌…”