Aerosol vaccination of mice with a live, temperature- sensitive recombinant influenza virus

Jemski, Joseph V.; Walker, Jerry S.

doi:10.1128/iai.13.3.818-824.1976

Cited by 11 publications

(1 citation statement)

References 19 publications

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“…Aerosol exposure of animal models such as mice, guinea pigs, and ferrets to influenza virus has been described. Studies in mice showed that, compared to intranasal inoculations, aerosol delivery of H3N2 influenza virus caused increased morbidity and mortality [75] and that aerosol delivery of antivirals and live-attenuated influenza vaccine virus is an effective method of disease prevention in this animal model [76,77]. Guinea pigs inoculated with aerosolized seasonal influenza virus reportedly were as contagious as those inoculated intranasally [52].…”

Section: Innovative Methods Of Influenza Virus Animal Inoculationsmentioning

confidence: 99%

Innovations in modeling influenza virus infections in the laboratory

Gustin

Belser

Katz

et al. 2012

Trends in Microbiology

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Respiratory viruses represent one of the most substantial infectious disease burdens to the human population today, and in particular, seasonal and pandemic influenza viruses pose a persistent threat to public health worldwide. In recent years, advances in techniques used in experimental research have provided the means to better understand the mechanisms of pathogenesis and transmission of respiratory viruses, and thus more accurately model these infections in the laboratory. Here, we briefly review the model systems used to study influenza virus infections, and focus particularly on recent advances that have increased our knowledge of these formidable respiratory pathogens.

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Section: Innovative Methods Of Influenza Virus Animal Inoculationsmentioning

confidence: 99%

Innovations in modeling influenza virus infections in the laboratory

Gustin

Belser

Katz

et al. 2012

Trends in Microbiology

View full text Add to dashboard Cite

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Clinical aerosols II. Therapeutic aerosols

Lourenço¹

1982

Archives of Internal Medicine

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The current uses of clinical aerosols such as water, saline, mucolytics, bronchodilators, cromolyn sodium, corticosteroids, and antimicrobials have been reviewed. The benefits of water, saline, and detergent aerosols continue to be surrounded by uncertainty and controversy. Aerosolized mucolytic and proteolytic agents have not been conclusively shown to be of substantial value in the improvement of respiratory disorders. Favorable bronchodilator therapy is achieved with aerosols of certain sympathomimetic and anticholinergic agents. However, successful therapy depends on the dose administered and the site of aerosol deposition in the lung. The prophylactic use of cromolyn sodium in patients with asthma is another useful application of aerosols. Topically active corticosteroid aerosols are increasingly being used since they may reduce risks of systemic effects from corticosteroids. Research on uncommonly aerosolized agents has widened the spectrum of therapeutic applications of aerosols.

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