Aerosol Steroid Therapy and Chronic Bronchial Asthma

Aerosolized Dexamethasone Isonicottnate in the Treatment of Bronchial Asthma

“…Our impression is tbat the inhaled dexametbasone isonicotinate might be more efficient to control asthmatic symptoms than oral corticoids, confirming the previous reports (1,2,3,5,6,7). In 84 per cent of tbe patients, the response to the steroid inhalation was better tban tbat to the placebo.…”

“…Approximately 0.5 mg dexamethasone isonicotinate (0.4 mg as dexamethasone) deposited in tbe airway is comparable with 1.7 tablets (95 per cent interval, 0.6^2.7 tablets) of oral corticosteroids, estimated equivalent to approximately 0.85 mg (95 per cent interval, 0.3'-^ 1.36 mg) orally administered dexamethasone. Our impression is tbat the inhaled dexametbasone isonicotinate might be more efficient to control asthmatic symptoms than oral corticoids, confirming the previous reports (1,2,3,5,6,7).…”

Beclomethasone Dipropionate: A New Steroid Aerosol for the Treatment of Allergic Asthma

“…Attempts to establish this method have been the subject of reports by many investigators from Gelfand (1951) onwards, including studies by Brockbank et al (1956), Brockbank and Pengelly (1958), Helm and Heyworth (1958), Herxheimer et al ( ), Smith (1958, Bickerman andItkin (1963), Brown (1963), and a further publication, including a review of nine others, by Kravis and Lecks (1966). Hydrocortisone was used as powder by early investigators, and later dexamethasone phos- Novey and Beall (1965), and Toogood and Lefcoe (1965).…”

Functional Evaluation of a Corticosteroid Molecule Activity, Dexamethasone-Isonicotinate, by Aerosol Dosage in Obstructive Lung Disease

“…Use of dexamethasone and its esters proved to be therapeutically effective [2,4,6,7,11,26,32], However, these esters, too, caused side-effects [32].…”