Aerosol Particle Generation from Dry Powder Inhalers: Can They Equal Pressurized Metered Dose Inhalers?

Olsson, Bo

doi:10.1089/jam.1995.8.suppl_3.s-13

Cited by 69 publications

(31 citation statements)

References 4 publications

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“…Both in vitro and in vivo deposition studies show that delivered drug fractions in the required aerodynamic size fraction from early capsule-based DPIs with adhesive mixtures are quite low ( Figure 1) [55,56]. The carrier-free formulation from the Turbuhaler generally performs much better, even in comparison with MDIs that deliver the same drug [57,58]. The explanation for this poor performance of the early capsule-based DPIs is in the strong interparticulate forces in the adhesive mixtures and the absence of efficient dispersion principles in these inhalers.…”

Section: 'Repair Actions' For Design Weaknesses Of Early Dpi Conceptsmentioning

confidence: 99%

Dry powder inhalation: past, present and future

Boer

Hagedoorn

Hoppentocht

et al. 2016

Expert Opinion on Drug Delivery

222

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Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked efficient dispersion principles. Therefore, particle engineering and powder processing are increasingly applied to achieve acceptable lung deposition with these poorly designed inhalers. Areas covered: The consequences of the choices made for early DPI development with respect of efficacy, production costs and safety and the tremendous amount of energy put into understanding and controlling the dispersion performance of adhesive mixtures are discussed. Also newly developed particle manufacturing and powder formulation processes are presented as well as the challenges, objectives, and new tools available for future DPI design. Expert opinion: Improved inhaler design is desired to make DPIs for future applications cost-effective and safe. With an increasing interest in high dose drug delivery, vaccination and systemic delivery via the lungs, innovative formulation technologies alone may not be sufficient. Safety is served by increasing patient adherence to the therapy, minimizing the use of unnecessary excipients and designing simple and self-intuitive inhalers, which give good feedback to the patient about the inhalation maneuver. For some applications, like vaccination and delivery of hygroscopic formulations, disposable inhalers may be preferred. ARTICLE HISTORY

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Section: 'Repair Actions' For Design Weaknesses Of Early Dpi Conceptsmentioning

confidence: 99%

Dry powder inhalation: past, present and future

Boer

Hagedoorn

Hoppentocht

et al. 2016

Expert Opinion on Drug Delivery

222

View full text Add to dashboard Cite

show abstract

“…Some show little variation with increasing flow rate whereas others show marked increases in inspirable particles with increasing flow rates. 12,[43][44][45][46][47] Forceful fast inhalations enhance the effect of many DPIs in children, whereas breath-holding, tilting of the head during inhalation or inhalation from functional residual capacity instead of residual volume do not seem to influence the clinical effect. 12 The inhalation effort and the inhalation flow rate required to generate the optimal therapeutic aerosol vary between different DPIs.…”

Section: Dry Powder Inhalersmentioning

confidence: 99%

The ADMIT series — Issues in Inhalation Therapy. 5) Inhaler selection in children with asthma

Pedersen

Dubus

Crompton³

2010

Primary Care Respiratory Journal

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“…An in vitro study comparing the proportion of the nominal dose of different corticosteroids delivered as fine drug particles from four different DPIs at different flow rates showed that the Turbuhaler device produced a higher proportion of respirable particles than the other devices, and this was consistent across the range of applied inspiratory force [12]. These in vitro findings need to be confirmed with in vivo deposition studies.…”

Section: Comparing Devices For Chronic Obstructive Pulmonary Diseasesmentioning

confidence: 91%

“…Due to the large amount of small particles and the moderate inbuilt resistance in Turbuhaler, which opens up the vocal cords during inhalation, Turbuhaler is associated with higher lung deposition (25e40% of the delivered dose) compared with pMDIs and other DPIs [12,16]. A good correlation has been found between lung deposition and clinical efficacy.…”

Section: Comparing Devices For Chronic Obstructive Pulmonary Diseasesmentioning

confidence: 99%

Which factors affect the choice of the inhaler in chronic obstructive respiratory diseases?

Scichilone

Benfante

Bocchino

et al. 2015

Pulmonary Pharmacology & Therapeutics

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a b s t r a c tInhalation is the preferred route of drug administration in chronic respiratory diseases because it optimises delivery of the active compounds to the targeted site and minimises side effects from systemic distribution. The choice of a device should be made after careful evaluation of the patient's clinical condition (degree of airway obstruction, comorbidities), as well as their ability to coordinate the inhalation manoeuvre and to generate sufficient inspiratory flow. These patient factors must be aligned with the specific advantages and limitations of each inhaler when making this important choice. Finally, adherence to treatment is not the responsibility of the patient alone, but should be shared also by clinicians. Clinicians have access to a wide selection of pressurised metered dose inhalers (pMDIs) and dry powder inhalers (DPIs) that can be used effectively when matched to the needs of individual patients; this should be perceived as an opportunity rather than a limitation.

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Aerosol Particle Generation from Dry Powder Inhalers: Can They Equal Pressurized Metered Dose Inhalers?

Cited by 69 publications

References 4 publications

Dry powder inhalation: past, present and future

Dry powder inhalation: past, present and future

The ADMIT series — Issues in Inhalation Therapy. 5) Inhaler selection in children with asthma

Which factors affect the choice of the inhaler in chronic obstructive respiratory diseases?

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