Experimental measurements of the penetration and pressure drop across nuciepore filters (NPF) during clogging were made. The carrier gases for the pressure drop measurements consisted of argon, helium, methane, and different binary mixtures of these gases. The semiempirical Spumy equation for pressure drop across NPF was modified to account for carrier gases other than air and for polydispersity of pore sizes. Agreement of experiment with theory was good. Penetration measurements were carried out as a function of time for 3.0 and 5.0 ,um NPF. Argon and methane were used as the carrier gas. Comparisons of the penetration as a function of pressure drop were consistent with the clogging model proposed by Spurny.