2021
DOI: 10.1101/2021.01.29.21250552
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Aerosol emission from the respiratory tract: an analysis of relative risks from oxygen delivery systems

Abstract: BackgroundRisk of aerosolisation of SARS-CoV-2 directly informs organisation of acute healthcare and PPE guidance. Continuous positive airways pressure (CPAP) and high-flow nasal oxygen (HFNO) are widely used modes of oxygen delivery and respiratory support for patients with severe COVID-19, with both considered as high risk aerosol generating procedures. However, there are limited high quality experimental data characterising aerosolisation during oxygen delivery and respiratory support.MethodsHealthy volunte… Show more

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Cited by 32 publications
(34 citation statements)
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“…The levels of environmental contamination in our study were not significantly influenced by CPAP/HFNO therapies and/or coughing. These findings broadly reflect data from aerosol generation studies in healthy adult volunteers which report non-invasive positive pressure ventilation (NIPPV) and HFNO did not generate significantly more aerosols (compared to other respiratory activities) 21 24 or in fact reduced emissions for NIPPV and HFNO 22 and CPAP 23 . This may be influenced by the semi-closed system of CPAP delivery and PEEP over the nose and mouth simultaneously that limit aerosol/droplet dispersion from respiratory secretions.…”
Section: Discussionsupporting
confidence: 79%
“…The levels of environmental contamination in our study were not significantly influenced by CPAP/HFNO therapies and/or coughing. These findings broadly reflect data from aerosol generation studies in healthy adult volunteers which report non-invasive positive pressure ventilation (NIPPV) and HFNO did not generate significantly more aerosols (compared to other respiratory activities) 21 24 or in fact reduced emissions for NIPPV and HFNO 22 and CPAP 23 . This may be influenced by the semi-closed system of CPAP delivery and PEEP over the nose and mouth simultaneously that limit aerosol/droplet dispersion from respiratory secretions.…”
Section: Discussionsupporting
confidence: 79%
“…This finding has potential implications for the application of protective measures within a hospital environment, wherease face mask usage was enforced for individuals in outpatients and for HCWs in all areas of the hospital, inpatients were not at the time of data collection subject to the same precautions. A recent study has suggested SARS-CoV-2 aerosolisation to be high in areas where patients with COVID-19 are coughing ( Hamilton, 2021 ).…”
Section: Discussionmentioning
confidence: 99%
“…This finding has potential implications for the application of protective measures within a hospital environment; while face mask usage was enforced for individuals in outpatients and for HCWs in all areas of the hospital, inpatients were not at the time of data collection subject to the same precautions. A recent study has suggested SARS-CoV-2 aerosolisation to be high in areas where patients with COVID-19 are coughing 27 .…”
Section: Discussionmentioning
confidence: 99%