Aerosol characterization using mass spectrometry

Noble, Christopher A.; Nordmeyer, Trent; Salt, K.; Morrical, Bradley D.; Prather, Kimberly A.

doi:10.1016/0165-9936(94)85042-9

Cited by 36 publications

(22 citation statements)

References 17 publications

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“…For obtaining particle size information, researchers have incorporated ion signal integration (34,35,40,46), light scattering intensity measurement (37-39, 41, 47), visual observation through a telescope (45), and single-laser (39) and dual-laser aerodynamic particle sizing (42)(43)(44)47). For obtaining particle size information, researchers have incorporated ion signal integration (34,35,40,46), light scattering intensity measurement (37-39, 41, 47), visual observation through a telescope (45), and single-laser (39) and dual-laser aerodynamic particle sizing (42)(43)(44)47).…”

Section: Introductionmentioning

confidence: 99%

Real-Time Measurement of Correlated Size and Composition Profiles of Individual Atmospheric Aerosol Particles

Noble

Prather

1996

Environ. Sci. Technol.

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251

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In this paper, the unique real-time measurement capabilities of aerosol time-of-flight mass spectrometry (ATOFMS) for characterizing atmospheric aerosol particles are demonstrated. ATOFMS is used to obtain the aerodynamic size and chemical composition of individual aerosol particles sampled directly into the instrument from outdoors. Such measurements are made in-situ by combining a unique dual-laser aerodynamic particle sizing system to size and track individual particles through the instrument and laser desorption/ionization time-of-flight mass spectrometry to obtain correlated single particle composition data. At typical ambient concentrations, the size and chemical composition of 50−100 particles per minute can be measured (up to 600 per minute at high particle concentrations). Presented here for the first time are compositionally resolved particle size distributions of ambient aerosol particles, showing definitive size/composition correlations. A goal of these studies is to ultimately couple data obtained from the dynamic monitoring of individual particles in atmospheric systems with that obtained using conventional ambient aerosol sampling to assist in sorting out complex field data on atmospheric processes.

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Section: Introductionmentioning

confidence: 99%

Real-Time Measurement of Correlated Size and Composition Profiles of Individual Atmospheric Aerosol Particles

Noble

Prather

1996

Environ. Sci. Technol.

Self Cite

251

193

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“…In 1988, Marijnissen et al proposed the use of a time-of-flight mass spectrometer (TOFMS) [8], but McKeown et al in 1991 were the first to build and describe an on-line system [9]. Prather et al added aerodynamic sizing to a TOFMS to enable the accurate sizing and efficient analysis of polydisperse aerosols in 1994 [10]. In 1996, Hinz et al effectively doubled the amount of information obtained from individual particles by utilizing a dual polarity TOFMS [11].…”

mentioning

confidence: 99%

Parameters contributing to efficient ion generation in aerosol MALDI mass spectrometry

McJimpsey

Jackson

Lebrilla

et al. 2008

J. Am. Soc. Mass Spectrom.

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The Bioaerosol Mass Spectrometry (BAMS) system was developed for the real-time detection and identification of biological aerosols using laser desorption ionization. Greater differentiation of particle types is desired; consequently MALDI techniques are being investigated. The small sample size (ϳ1 m 3 ), lack of substrate, and ability to simultaneously monitor both positive and negative ions provide a unique opportunity to gain new insight into the MALDI process. Several parameters known to influence MALDI molecular ion yield and formation are investigated here in the single particle phase. A comparative study of five matrices (2,6-dihydroxyacetophenone, 2,5-dihydroxybenzoic acid, ␣-cyano-4-hydroxycinnamic acid, ferulic ␣ acid, and sinapinic acid) with a single analyte (angiotensin I) is presented and reveals effects of matrix selection, matrix-to-analyte molar ratio, and aerosol particle diameter. The strongest analyte ion signal is found at a matrix-to-analyte molar ratio of 100:1. At this ratio, the matrices yielding the least and greatest analyte molecular ion formation are ferulic acid and ␣-cyano-␣ 4-hydroxycinnamic acid, respectively. Additionally, a significant positive correlation is found between aerodynamic particle diameter and analyte molecular ion yield for all matrices. SEM imaging of select aerosol particle types reveals interesting surface morphology and structure.

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“…All experiments were performed using a TSI 3800 AToFMS instrument (TSI, Shoreview MN USA). This instrument is described in detail elsewhere,7, 15 and hence only a brief description of the operation is provided below.…”

Section: Methodsmentioning

confidence: 99%

“…The ability of single particle mass spectrometry (SPMS) to make near real‐time measurements of particle size and chemical composition6, 7 is an attractive alternative in the field of pharmaceutical aerosol analysis.…”

mentioning

confidence: 99%

Detection and assessment of co‐association in inhalable drug particles using aerosol time‐of‐flight mass spectrometry

New

Prime

Zomer

et al. 2008

Rapid Comm Mass Spectrometry

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Aerosol Time-of-Flight Mass Spectrometry (AToFMS) was used to examine co-association between two inhaled drugs, fluticasone propionate (FP) and salmeterol xinofoate (SX), in fine aerosolised particles emitted from Seretide(R)/Advair(R) inhaled combination products. Principal Component Analysis (PCA) was used to identify fragmentation patterns indicative of either pure or co-associated particles (particles containing both drugs). A third component of the particles emitted from dry powder inhalers (DPIs), lactose, gave only a very weak mass spectral signal and no interpretable data was acquired for this compound; however, it was not found to interfere with the detection of the two drug substances. High levels of co-association were found in the emitted doses from both pressurised metered dose inhaler (pMDI) and dry powder inhaler (DPI) products.

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Aerosol characterization using mass spectrometry

Cited by 36 publications

References 17 publications

Real-Time Measurement of Correlated Size and Composition Profiles of Individual Atmospheric Aerosol Particles

Real-Time Measurement of Correlated Size and Composition Profiles of Individual Atmospheric Aerosol Particles

Parameters contributing to efficient ion generation in aerosol MALDI mass spectrometry

Detection and assessment of co‐association in inhalable drug particles using aerosol time‐of‐flight mass spectrometry

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