Aerosol‐assisted open‐air plasma deposition of acrylate‐based composite coatings: Molecule release control through precursor selection

Abstract

Aerosol-assisted open-air plasma allows the direct deposition of composite coatings with embedded bioactive agents. However, the deposition of biodegradable coatings for controlled drug release application remains challenging. In this study, an innovative precursor injection strategy is used to entrap tracers in coatings deposited from various acrylate-based precursors: Acrylic acid (AA), methacrylic anhydride (MA), and 1,4-butanediol diacrylate (BDDA). Water immersion tests show dramatically different release kinetics ranging from over minutes to weeks and months for AA, MA, and BDDA, respectively. These different behaviors are correlated to the crosslinking degree and the hydrolysis rates of the crosslinking functions. This original approach allows controlled release of tracers entrapped in biodegradable acrylate-based coatings and provides new insights for drug-release application.

Carbon Dots Release from Biodegradable Coatings Deposited by Aerosol-Assisted Open-Air Plasma

“…Interestingly, whatever the precursor used, the thickness of the coatings, is similar: 5.0 ± 0.9 μm for pPMA and 4.9 ± 0.5 μm for pPEGDMA (Fig 1e,f), meaning that they have similar deposition rates. It is worth noting that, compared to previously reported results [9], doubling the deposition time from 5 to 10 min leads to a twice thicker coating, from 2.5 μm to 5.0 μm, suggesting constant deposition rates, as already observed for AA-APPD [8]. Entrapment of CD.…”

“…Aerosol assisted plasma deposition at atmospheric pressure. AA-APPD process was carried out as described in a previous study [9], but with a deposition time of 10 min. Briefly, a dual nebulization system was used to generate an aerosol of precursor and an aerosol of aqueous CDs in an argon stream.…”

“…However, the trade-off between deposition of biodegradable composite coatings, trapping CDs, and the control of their release remains challenging. In this context, an aerosol-assisted APPD (AA-APPD) has recently been reported to be able to entrap tunable quantity of various watersoluble agents within directly deposited biodegradable coatings [8,9]. This method appears to be suitable to deposit any water-soluble agent, such as CDs.…”

“…In this work, the feasibility of depositing biodegradable coatings containing CDs in a single step by AA-APPD was investigated. Coatings were deposited from methacrylic anhydride (MA) and ethylene glycol dimethylacrylate (EGDMA), as precursors, selected for their different hydrolysable moieties, anhydride and ester, respectively [9,10]. The composition of the coatings as well as their morphology with and without entrapped CDs were assessed.…”

A2B2-Type Zinc(II) Porphyrin-Modified Organic Polymers with Flexible Linkers for Efficient Fixation of CO2 to Cyclic Carbonate

“…As far as we know, hydrogels are three-dimensional network structures consisting of polymeric chains and are swollen in water up to thermodynamic equilibrium. , Inspired by the swelling effect of hydrogels, we wondered whether the polymers prepared by flexible linkers could expand their volume in the substrate solvent and thus facilitate the contact between the substrate and the active sites. To our delight, 1,4-butanediol diacrylate (BDDA) not only had a long flexible chain but also was an ideal connector of copolymers due to the direct connection between the ester carbonyl group and the alkene bond. − Simultaneously, the high degree of cross-linking may cause the polymers to pack tightly, which was not conducive to the exposure of the active sites. Therefore, the A 4 -type porphyrins were adjusted to the A 2 B 2 -type porphyrins in order to reduce the degree of cross-linking.…”