Aeromonas Species

Lobatón, Triana; Hoffman, Ilse; Vermeire, Séverine; Ferrante, Marc; Verhaegen, Jan; Assche, Gert Van

doi:10.1097/mib.0000000000000247

Cited by 28 publications

(16 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple genera were significantly enriched in the diseases compared to the healthy controls. Most of these genera have been reported as opportunistic pathogens of the human gut [58–67]. These disease-enriched genera typically showed higher abundance and higher variance in disease subjects compared to the healthy ones (first and second columns of Additional file 4: figure 2), while all of these genera exhibit low abundance in the dataset used here (third column of Additional file 4: figure 2).…”

Section: Discussionmentioning

confidence: 91%

Aging progression of human gut microbiota

2019

View full text Add to dashboard Cite

BackgroundHuman gut microbiota are important for human health and have been regarded as a “forgotten organ”, whose variation is closely linked with various factors, such as host genetics, diet, pathological conditions and external environment. The diversity of human gut microbiota has been correlated with aging, which was characterized by different abundance of bacteria in various age groups. In the literature, most of the previous studies of age-related gut microbiota changes focused on individual species in the gut community with supervised methods. Here, we aimed to examine the underlying aging progression of the human gut microbial community from an unsupervised perspective.ResultsWe obtained raw 16S rRNA sequencing data of subjects ranging from newborns to centenarians from a previous study, and summarized the data into a relative abundance matrix of genera in all the samples. Without using the age information of samples, we applied an unsupervised algorithm to recapitulate the underlying aging progression of microbial community from hosts in different age groups and identify genera associated to this progression. Literature review of these identified genera indicated that for individuals with advanced ages, some beneficial genera are lost while some genera related with inflammation and cancer increase.ConclusionsThe multivariate unsupervised analysis here revealed the existence of a continuous aging progression of human gut microbiota along with the host aging process. The identified genera associated to this aging process are meaningful for designing probiotics to maintain the gut microbiota to resemble a young age, which hopefully will lead to positive impact on human health, especially for individuals in advanced age groups.

show abstract

Section: Discussionmentioning

confidence: 91%

Aging progression of human gut microbiota

2019

View full text Add to dashboard Cite

show abstract

“…In one of the ileal samples, we identified an unexpected presence of Aeromonas hydrophila and veronii (5%; see Fig. 2); infection with this enteropathogen is associated with a poor clinical outcome in IBD [27]. In another patient, both the stool and ileal samples contained a high fraction (0.4 and 4.2%) of Fusobacterium varium, which is a species associated with and able to induce ulcerative colitis [28].…”

Section: Resultsmentioning

confidence: 99%

Genetic diversity of Escherichia coli in gut microbiota of patients with Crohn’s disease discovered using metagenomic and genomic analyses

et al. 2018

View full text Add to dashboard Cite

BackgroundCrohn’s disease is associated with gut dysbiosis. Independent studies have shown an increase in the abundance of certain bacterial species, particularly Escherichia coli with the adherent-invasive pathotype, in the gut. The role of these species in this disease needs to be elucidated.MethodsWe performed a metagenomic study investigating the gut microbiota of patients with Crohn’s disease. A metagenomic reconstruction of the consensus genome content of the species was used to assess the genetic variability.ResultsThe abnormal shifts in the microbial community structures in Crohn’s disease were heterogeneous among the patients. The metagenomic data suggested the existence of multiple E. coli strains within individual patients. We discovered that the genetic diversity of the species was high and that only a few samples manifested similarity to the adherent-invasive varieties. The other species demonstrated genetic diversity comparable to that observed in the healthy subjects. Our results were supported by a comparison of the sequenced genomes of isolates from the same microbiota samples and a meta-analysis of published gut metagenomes.ConclusionsThe genomic diversity of Crohn’s disease-associated E. coli within and among the patients paves the way towards an understanding of the microbial mechanisms underlying the onset and progression of the Crohn’s disease and the development of new strategies for the prevention and treatment of this disease.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-5306-5) contains supplementary material, which is available to authorized users.

show abstract

“…[ 17 ] Aeromonas can be a trigger of flare-ups or the development of IBD and cause a more severe infection in IBD patients than in non-IBD patients. [ 8 ] The incidence of C . difficile in IBD has doubled in recent years, increasing significantly in UC patients.…”

Section: Discussionmentioning

confidence: 99%

“…[ 6 ] The role of Aeromonas species in UC is controversial, but recent studies have suggested that it can trigger UC relapse. [ 7 , 8 ]…”

Section: Introductionmentioning

confidence: 99%

Challenges in the diagnosis of ulcerative colitis with concomitant bacterial infections and chronic infectious colitis

Lin¹,

Chang²,

Chen³

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

Ulcerative colitis (UC) is a chronic inflammation of the large bowel characterized by diarrhea and a negative stool culture. However, several enteropathogens have been implicated as causative agents in UC. The differentiation between chronic infectious colitis (IC) and UC with concurrent infection is difficult owing to their similar clinical presentations. The study aimed to explore the presentations and diagnostic clues that enable differentiation between UC with concomitant infections and chronic IC. The study included 17 UC patients with a bacterial infection and 46 with chronic IC. The UC patients (47 ± 19 years) were younger than the chronic IC patients (58 ± 20 years) (P = 0.022). Bloody diarrhea was more common in UC than in chronic IC (58.8% vs 10.9%, P < 0.001). Previous antibiotic usage was a risk factor for chronic IC (5.9% vs 32.6%, P = 0.031). Malignancy was a common comorbidity of chronic IC (5.9% vs 34.8%, P = 0.022). UC patients had lower antibiotic response rates than chronic IC patients (60.0% vs 87.2%, P = 0.026). Aeromonas species and Clostridium difficile were common in both groups. Histological features of cryptitis and crypt abscess were useful in the diagnosis of UC (P = 0.052 and P = 0.016, respectively). Bloody diarrhea in a young adult, decreased response to antibiotic treatment, and results of endoscopy with biopsy are important features in the diagnosis of UC with bacterial infection.

show abstract

Aeromonas Species

Cited by 28 publications

References 64 publications

Aging progression of human gut microbiota

Aging progression of human gut microbiota

Genetic diversity of Escherichia coli in gut microbiota of patients with Crohn’s disease discovered using metagenomic and genomic analyses

Challenges in the diagnosis of ulcerative colitis with concomitant bacterial infections and chronic infectious colitis

Contact Info

Product

Resources

About