Aerogels: Tailor-made Carriers for Immediate and Prolonged Drug                    Release

Смирнова, Ирина; Suttiruengwong, Supakij; Arlt, Wolfgang

doi:10.14356/kona.2005012

Cited by 58 publications

(34 citation statements)

References 29 publications

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“…Smirnova et al [54] reported the possibility of controlling the dissolution rate of poorly soluble drugs by adsorption on silica aerogels with various properties. The drug concentration in aerogel is determined by the working temperature, bulk concentration of the drug in the supercritical solvent and the properties of the aerogel.…”

Section: Aerogelsmentioning

confidence: 99%

“…For a given drug, the loading increases with increasing surface area and volume of the mesopores of the aerogel, whereas hydrophilic samples have higher loading rates than hydrophobic ones in all cases. The authors showed that hydrophobic aerogels exhibited a slower release rate of drugs which is governed by diffusion, since such aerogels are more stable in water [54]. This property may prove useful for the prolonged release of fast dissolving drugs.…”

Section: Aerogelsmentioning

confidence: 99%

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Processing Polymeric Biomaterials using Supercritical CO₂

Knez

Markočič

Novak

et al. 2011

Chemie Ingenieur Technik

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The traditional methods for polymer processing involve either high temperatures, necessary for melting or viscosity reduction, or hazardous organic solvents and chlorofluorocarbons. Due to the undesirable environmental and biological impact of these solvents, intensive research is focused on seeking new and cleaner methods for the processing of polymers. The potential of supercritical (SC) CO 2 as solvent or plasticizer for the processing of polymeric materials is reviewed in this study. The results suggest that SC CO 2 due to its excellent properties, good solubility and plasticizing effect in polymers can be successfully used in processing biomaterials.

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Section: Aerogelsmentioning

confidence: 99%

Section: Aerogelsmentioning

confidence: 99%

Processing Polymeric Biomaterials using Supercritical CO₂

Knez

Markočič

Novak

et al. 2011

Chemie Ingenieur Technik

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“…Therefore, the structural properties of aerogels such as density, pore size, and surface area and the functionality of the surface influence the adsorption process and thus the maximum loading as well. For a given drug, the loading increases with increasing surface area and with the volume of the mesopores of the aerogel [10,11]. Usually, higher density aerogels, having larger surface areas, adsorb more drugs than samples of lower density [7].…”

Section: Loading Of Aerogels By Adsorptionmentioning

confidence: 99%

“…Although in reality more complex behaviour is expected, this fitting gives a first idea about the release rate: the release rate of ketoprofen from hydrophilic aerogel is five times higher than that of the crystalline drug. In case of another drug, griseofulvin, the release from silica aerogels was compared to that of the dissolution of griseofulvin micro-and nanoparticles [11]. As can be seen from Figure 31.5, the release rate increases with decreasing particle size and is by far the highest in case of the powdered aerogel formulation.…”

Section: Release Of the Drugs From Silica Aerogelsmentioning

confidence: 99%

Pharmaceutical Applications of Aerogels

Смирнова

2011

Aerogels Handbook

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At present, an interest has grown in the field of biocompatible aerogels and composite aerogel materials in life science, especially in biomedical and pharmaceutical applications. Due to their large surface area, open pore structure, and biocompatibility, aerogels are very promising candidates for drug delivery systems. The use of both inorganic and organic aerogels as carriers for pharmaceutically active compounds is discussed in this chapter. Both the stability and the release kinetics of the drug can be significantly improved by loading them into aerogels. First attempts to prepare semisolid and solid pharmaceutical formulations have been made. Furthermore, aerogels can be used as a host matrix for bioactive compounds (enzymes and proteins), which improve or enable their performance. Taking into account all research activities in the area of aerogels, a number of promising pharmaceutical applications can be expected in future. IntroductionSilica aerogels were used in daily life products since 1960s, when Monsanto's aerogels were introduced as additives for cosmetics and toothpaste. At present, an interest has grown in the field of biocompatible aerogels and composite aerogel materials in life sciences, especially for biomedical and pharmaceutical applications. In principle, biocompatible aerogels can be made from any organic compound, whose properties such as toxicity and biodegradation are suitable for the given application. In the case of aerogel composites, the final material consists of an aerogel matrix and one or more additional phases (of any composition or scale), which influence the properties of the final product. Thus, at least one phase has a physical structure with dimensions in the order of nanometres (the particles and pores of the aerogel). The aerogel composites can be prepared in two different ways: through the addition of a target compound during the sol-gel process (Figure 31.1A) and by post-treatment of the dried aerogels (Figure 31.1B), for example, by adsorption, vapour phase deposition, or reactive gas treatment.The first method (a) is attractive by its simplicity and flexibility, since virtually every material can be easily added to the sol solution before gelation. This added material can be of I. Smirnova

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“…These unique properties of aerogels attracted many researchers to explore them as drug delivery vehicles [1]- [5].…”

Section: Introductionmentioning

confidence: 99%

A Simple Process to Prepare Silica Aerogel Microparticles from Rice Husk Ash

Kumar¹,

Vinjamur²,

Mukhopadhyay³

2013

IJCEA

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Abstract-Biocompatible silica aerogel microparticles are promising drug delivery vehicles because of their large surface area and open pore structures. A simple process has been developed in this work to prepare silica aerogel microparticles from rice husk ash, using water-in-mineral oil emulsion for sol-gel, followed by aging in ethanol to strengthen gel network and drying with scCO 2 . This process obviates drawback of current methods for silica aerogels. The effects of speed of agitation of water-oil mixture, sol-to-oil ratio and surfactant concentration have been investigated on particle size and size distribution, BET surface area, cumulative pore volume and pore diameter. A surface area of 654 m 2 /g, higher than the values reported for similar materials, could be obtained.Index Terms-Rice husk ash, silica aerogel microparticles, supercritical carbon dioxide, water-in-oil emulsion.

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Aerogels: Tailor-made Carriers for Immediate and Prolonged Drug Release

Abstract: The potential of inorganic polymeric materials Ҁ silica aerogels Ҁ as tailor - In addition, the possibility of generating organic microparticles inside the pores of the aerogels by precipitation from supercritical solutions is discussed.

Cited by 58 publications

References 29 publications

Processing Polymeric Biomaterials using Supercritical CO₂

Processing Polymeric Biomaterials using Supercritical CO₂

Pharmaceutical Applications of Aerogels

A Simple Process to Prepare Silica Aerogel Microparticles from Rice Husk Ash

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Aerogels: Tailor-made Carriers for Immediate and Prolonged Drug Release

Abstract: The potential of inorganic polymeric materials Ҁ silica aerogels Ҁ as tailor - In addition, the possibility of generating organic microparticles inside the pores of the aerogels by precipitation from supercritical solutions is discussed.

Cited by 58 publications

References 29 publications

Processing Polymeric Biomaterials using Supercritical CO2

Processing Polymeric Biomaterials using Supercritical CO2

Pharmaceutical Applications of Aerogels

A Simple Process to Prepare Silica Aerogel Microparticles from Rice Husk Ash

Contact Info

Product

Resources

About

Processing Polymeric Biomaterials using Supercritical CO₂

Processing Polymeric Biomaterials using Supercritical CO₂