Aerogel from chemo-enzymatically oxidized fenugreek gum: an innovative delivery system of isothiazolinones biocides

Silvetti, Tiziana; Merlini, Luca; Brasca, Milena; Galante, Yves M.

doi:10.1007/s00253-018-8804-0

Cited by 9 publications

(7 citation statements)

References 50 publications

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“…[224] In 2018, Silvetti et al prepared fenugreek gum aerogels and loaded them with a mixture of two microbiocides: 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) and 2-methyl-4-isothiazolin-3-one (MIT). [225] A slow and complete release of CIT and MIT was achieved in water with the same minimal inhibitory concentration of free biocide, demonstrating activity against S. marcescens and P. aeruginosa. [225] Rossi et al prepared and evaluated an aerogel based on laccaseoxidized galactomannans as DDS of lysozyme, an anti-microbial enzyme that catalyzes cell wall destruction of certain bacteria.…”

Section: Drug Deliverymentioning

confidence: 87%

“…[225] A slow and complete release of CIT and MIT was achieved in water with the same minimal inhibitory concentration of free biocide, demonstrating activity against S. marcescens and P. aeruginosa. [225] Rossi et al prepared and evaluated an aerogel based on laccaseoxidized galactomannans as DDS of lysozyme, an anti-microbial enzyme that catalyzes cell wall destruction of certain bacteria. [226] Lyophilization was used to prepare the aerogel, resulting in a water-insoluble aerogel with a swelling rate of 20 times its initial weight in aqueous and organic solvents.…”

Section: Drug Deliverymentioning

confidence: 87%

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Aerogel‐Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease‐Targeting Applications

et al. 2023

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Aerogel‐based biomaterials are increasingly being considered for biomedical applications due to their unique properties such as high porosity, hierarchical porous network, and large specific pore surface area. Depending on the pore size of the aerogel, biological effects such as cell adhesion, fluid absorption, oxygen permeability, and metabolite exchange can be altered. Based on the diverse potential of aerogels in biomedical applications, this paper provides a comprehensive review of fabrication processes including sol‐gel, aging, drying, and self‐assembly along with the materials that can be used to form aerogels. In addition to the technology utilizing aerogel itself, it also provides insight into the applicability of aerogel based on additive manufacturing technology. To this end, how microfluidic‐based technologies and 3D printing can be combined with aerogel‐based materials for biomedical applications is discussed. Furthermore, previously reported examples of aerogels for regenerative medicine and biomedical applications are thoroughly reviewed. A wide range of applications with aerogels including wound healing, drug delivery, tissue engineering, and diagnostics are demonstrated. Finally, the prospects for aerogel‐based biomedical applications are presented. The understanding of the fabrication, modification, and applicability of aerogels through this study is expected to shed light on the biomedical utilization of aerogels.

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Section: Drug Deliverymentioning

confidence: 87%

Section: Drug Deliverymentioning

confidence: 87%

Aerogel‐Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease‐Targeting Applications

et al. 2023

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“…The laccase/TEMPO oxidation of galactomannans led to the production of an aerogel with satisfactory drug delivery properties [175]. Similar materials were also obtained by the laccase oxidation of fenugreek gum [176]. Chitosan hydrogels with laccase-oxidized phenolics as crosslinkers showed improved swelling properties and suitable biocompatibility as well as conductive gels based on chitosan and hyaluronic acid [177], (CN104725657A).…”

Section: Nanobiotechnology and Biomedicinementioning

confidence: 94%

Applications of Microbial Laccases: Patent Review of the Past Decade (2009–2019)

et al. 2019

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There is a high number of well characterized, commercially available laccases with different redox potentials and low substrate specificity, which in turn makes them attractive for a vast array of biotechnological applications. Laccases operate as batteries, storing electrons from individual substrate oxidation reactions to reduce molecular oxygen, releasing water as the only by-product. Due to society’s increasing environmental awareness and the global intensification of bio-based economies, the biotechnological industry is also expanding. Enzymes such as laccases are seen as a better alternative for use in the wood, paper, textile, and food industries, and they are being applied as biocatalysts, biosensors, and biofuel cells. Almost 140 years from the first description of laccase, industrial implementations of these enzymes still remain scarce in comparison to their potential, which is mostly due to high production costs and the limited control of the enzymatic reaction side product(s). This review summarizes the laccase applications in the last decade, focusing on the published patents during this period.

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“…In comparison to other approaches, the use of laccases for the reoxidation of TEMPO proved to be very mild and, promoting a lower degree of oxidations, resulted in the formation of soft gels. The properties of these materials, specifically those obtained by the LMS oxidation of guar polygalactomannanes, was recently investigated by Galante and coworkers and reported in a series of publications [61][62][63][64][65][66][67].…”

Section: Laccase-mediator Systems: From Alcohols Bio-oxidation To Integrated Chemoenzymatic Systemsmentioning

confidence: 99%

“…Catalysts 2021, 11, x FOR PEER REVIEW 7 of 34 erties of these materials, specifically those obtained by the LMS oxidation of guar polygalactomannanes, was recently investigated by Galante and coworkers and reported in a series of publications [61][62][63][64][65][66][67].…”

Section: Laccase-mediator Systems: From Alcohols Bio-oxidation To Integrated Chemoenzymatic Systemsmentioning

confidence: 99%

Biocatalysis with Laccases: An Updated Overview

et al. 2020

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Laccases are multicopper oxidases, which have been widely investigated in recent decades thanks to their ability to oxidize organic substrates to the corresponding radicals while producing water at the expense of molecular oxygen. Besides their successful (bio)technological applications, for example, in textile, petrochemical, and detoxifications/bioremediations industrial processes, their synthetic potentialities for the mild and green preparation or selective modification of fine chemicals are of outstanding value in biocatalyzed organic synthesis. Accordingly, this review is focused on reporting and rationalizing some of the most recent and interesting synthetic exploitations of laccases. Applications of the so-called laccase-mediator system (LMS) for alcohol oxidation are discussed with a focus on carbohydrate chemistry and natural products modification as well as on bio- and chemo-integrated processes. The laccase-catalyzed Csp2-H bonds activation via monoelectronic oxidation is also discussed by reporting examples of enzymatic C-C and C-O radical homo- and hetero-couplings, as well as of aromatic nucleophilic substitutions of hydroquinones or quinoids. Finally, the laccase-initiated domino/cascade synthesis of valuable aromatic (hetero)cycles, elegant strategies widely documented in the literature across more than three decades, is also presented.

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Aerogel from chemo-enzymatically oxidized fenugreek gum: an innovative delivery system of isothiazolinones biocides

Cited by 9 publications

References 50 publications

Aerogel‐Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease‐Targeting Applications

Aerogel‐Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease‐Targeting Applications

Applications of Microbial Laccases: Patent Review of the Past Decade (2009–2019)

Biocatalysis with Laccases: An Updated Overview

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