Stanton numbers, skin friction coefficients, aerodynamic losses, and Reynolds analogy behavior are numerically predicted for a turbine vane using the FLUENT commercial code with a k-e RNG model to show the effects of Mach number, mainstream turbulence level, and surface roughness. Test vane geometry, configuration, and flow conditions match ones from a practical application. Comparisons with experimental data on wake aerodynamic losses are made. Numerical and experimental results show that the magnitudes of integrated aerodynamics losses increase dramatically as the exit Mach number increases from 0.35 to 0.71. Downstream wakes are also widened as the mainstream turbulence intensity level, exit Mach number, or level of surface roughness increases. Deviations of numerically predicted 2 St=C f magnitudes from 2 St=C f ffi 1 on the vane suction and pressure sides are also presented for a variety of flow conditions.