As a fundamental step towards the development of a civil high-speed transport concept, the European Community (EC) co-funded HEXAFLY-INT international project (with partners from Europe, Russian Federation, Brazil and Australia), has the aim to design, manufacture and test in flight an innovative gliding hypersonic vehicle, based on the configuration developed in previous EC co-funded projects LAPCAT I, II and HEXAFLY. The flight experiment is focused on a self-controlled glider configuration characterized by high aerodynamic efficiency and equipped with several breakthrough technologies on-board, in order to provide valuable aerodynamic and aero-structural flight data to validate methods and technologies used to design the hypersonic vehicle. In this framework, this paper provides a detailed overview on research efforts carried out in assessing the aerodynamic performance of the expendable Experimental Flight Test Vehicle under development in the programme. Aerodynamic results are obtained by means of a massive number of CFD simulations of increasing level of accuracy and through an experimental test campaign carried out at TsAGI in their T-116 wind tunnel facility.