Aerococcus urinae, a cause of cystitis with malodorous urine in a child: clinical and microbiological challenges

Skalidis, Tilemachos; Papaparaskevas, J.; Konstantinou, Dimitrios; Kapolou, Eleni; Falagas, Mathhew E.; Legakis, Nicholas J.

doi:10.1099/jmmcr.0.005083

Cited by 11 publications

(8 citation statements)

References 17 publications

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“…supported by a growing number of case reports [5][6][7][8][9][10][11][12]. The case reported by Higgins and Garg [12] presents many similarities to the case we describe in this article, since they both regard elderly patients with bladder neoplasms and multiple comorbidities.…”

Section: Aerococcus Urinae 'S Association To Urinary Tract Infections Issupporting

confidence: 60%

Untitled

2022

AJBSR

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Section: Aerococcus Urinae 'S Association To Urinary Tract Infections Issupporting

confidence: 60%

Untitled

2022

AJBSR

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“…The need for prompt identification and treatment increases as newer sequelae of disease are discovered. Rare reports refer to A. urinae as a cause of invasive human infections, such as sepsis, endocarditis, peritonitis, spondylodiscitis and vertebral osteomyelitis [5]. Unidentified cases can rapidly deteriorate into major infections as in the case of necrotizing urethritis.…”

Section: Discussionmentioning

confidence: 99%

An Uncommon Cause of Urinary Tract Infections: A Case Report

Otero-Colón¹,

Farraj²,

Desai³

2022

Cureus

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Urinary tract infections (UTI) in the elderly are common. UTI ranges in severity from mild disease to severe sepsis. Many organisms can cause UTIs yet many UTIs are caused by the same few organisms. An organism that has been increasingly gaining notoriety for infections is Aerococcus urinae. Aerococcus infections are constantly misdiagnosed due to their difficulty to identify. Here we present a case of an elderly male who was found to have a urinary tract infection with Aerococcus urinae that progressed into bacteremia, severe sepsis and ultimately death.

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“…Urogenital disorders were also described in some of the case reports on A. urinae infections in children. A bladder diverticulum was found in a 5-year-old boy with malodorous urine [ 8 ], and prior pyeloplasty and VUR were described in a 12-year-old boy with an A. urinae UTI [ 10 ]. The association of urogenital disorders and recurrent detection also correlates with data from a mouse model that showed susceptibility to prolonged bacteriuria with A. urinae in mice with inherent vesicoureteral reflux [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the case of A. urinae , the presence of additional pathogens in urine culture is reported potentially enhancing the extraordinary odour [ 6 ]. However, monoculture has been more frequently reported in case reports when A. urinae is detected with malodorous urine [ 5 , 8 , 9 ]. For A. urinae infection, most case reports suggest it is a low-grade pathogen, with only a few cases of more severe presentations.…”

Section: Introductionmentioning

confidence: 99%

Aerococcus urinae — significance of detection in the paediatric urinary tract: a case series

et al. 2022

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Aerococcus urinae (A. urinae) is primarily recognized as a common pathogen in the geriatric population, causing urinary tract infection (UTI), sepsis, and endocarditis, predominantly in female patients. In the paediatric population, only a few case reports exist suggesting A. urinae causes malodorous urine in otherwise healthy boys. In this study, we investigated the spectrum of clinical and laboratory presentations of A. urinae detection in children. A retrospective, single-centre, case series including all patients with the detection of A. urinae during a 7-year study period. Patients with detection of A. urinae only in non-urogenital skin swabs were excluded. A total of 40 samples from 33 patients were identified of which 20 patients were included in the final analysis. The median (IQR) age was 6.8 (2.9–9.5) years; 18 (90%) patients were boys. Four patients were diagnosed with a UTI, six had malodorous urine without UTI, three were diagnosed with balanitis and seven showed A. urinae colonization in the urine culture. Urogenital disorders were present in 12 patients. Additional pathogens were detected in 13 patients. Recurrence of detection during our study period was observed in four (20%) patients. Conclusion: Beyond malodorous urine, A. urinae detection is associated with more severe presentations including UTI in the paediatric population. Pre-existing urogenital disorders were frequent, and therefore, a nephro-urological investigation should be considered in all cases of A. urinae detection in the paediatric population. What is Known:• Aerococcus urinae (A. urinae) is known to be a common pathogen in the geriatric population, causing urinary tract infection (UTI), sepsis, and endocarditis, predominantly in female patients.• In the paediatric population, A. urinae is mainly described as a low-grade pathogen. Some case reports describe A. urinae as the cause of extraordinary malodorous urine in otherwise healthy boys. What is New:• Beyond malodorous urine, A. urinae detection is associated with more severe presentations including UTI in the paediatric population.• A. urinae was mainly detected in boys with pre-existing urogenital disorders; therefore, a nephro-urological investigation should be considered in cases of A. urinae detection in the paediatric population.

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Aerococcus urinae, a cause of cystitis with malodorous urine in a child: clinical and microbiological challenges

Cited by 11 publications

References 17 publications

Untitled

Untitled

An Uncommon Cause of Urinary Tract Infections: A Case Report

Aerococcus urinae — significance of detection in the paediatric urinary tract: a case series

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