Aerobic Training Suppresses Exercise-Induced Lipid Peroxidation and Inflammation in Overweight/Obese Adolescent Girls

Youssef, Hala; Groussard, Carole; Lemoine-Morel, Sophie; Pincemaïl, Joël; Jacob, Christophe; Moussa, Elie; Fazah, Abdallah; Cillard, Josiane; Pineau, Jean-Claude; Delamarche, Arlette

doi:10.1123/pes.2014-0008

Cited by 18 publications

(26 citation statements)

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“…Of the 6478 citations screened after removing duplicates both electronically and manually, 57 studies representing 127 groups (73 exercise, 54 control) and 2792 participants (1667 exercise, 1125 control) met the criteria for inclusion 13–40 42–69 98. The number needed to screen was 0.88% while the NNR was 114.…”

Section: Resultsmentioning

confidence: 99%

“…The included studies were published in 45 different journals since 1997 ( trueX- ± SD = 2011±4, median=2012). Fifty-two studies (91.2%) were published in the English language,13 14 16–18 20 22 24–40 42–69 while the remaining five (8.8%) were published in either Chinese19 21 23 98 or Spanish 15. The location in which studies were conducted included 20 different countries, 12 in the USA,24 30 34 35 39 40 46 48 52 56 60 66 8 in China,19–23 38 61 62 98 6 in Brazil,13 15 45 47 58 63 5 in South Korea,36 37 49 55 59 4 in Tunisia,17 25 50 51 3 each in Australia,54 64 65 Canada14 32 57 and Iran,27 29 69 2 in Turkey,33 53 and 1 each in either France,16 Germany,44 Italy,28 Lebanon,68 New Zealand,42 Norway,18 Singapore,67 Sweden,31 Switzerland,26 Taiwan22 or the UK 43.…”

Section: Resultsmentioning

confidence: 99%

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Exercise and adiposity in overweight and obese children and adolescents: a systematic review with network meta-analysis of randomised trials

Kelley

Pate

2019

BMJ Open

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ObjectivesDetermine both the effects and hierarchy of effectiveness for exercise interventions (aerobic, strength training or both) on selected measures of adiposity (body mass index (BMI) in kg/m2, fat mass and per cent body fat) in overweight and obese children and adolescents.DesignNetwork meta-analysis of randomised exercise intervention trials.SettingAny setting where a randomised trial could be conducted.ParticipantsOverweight and obese male and/or female children and adolescents 2–18 years of age.InterventionsRandomised exercise intervention trials>4 weeks, published between 1 January 1973 and 22 August 2018, and which included direct and/or indirect evidence for aerobic, strength training or combined aerobic and strength training.Primary outcomesChanges in BMI in kg/m2, fat mass and per cent body fat.ResultsFifty-seven studies representing 127 groups (73 exercise, 54 control) and 2792 participants (1667 exercise, 1125 control) met the criteria for inclusion. Length of training (trueX- ± SD) averaged 14.1±6.2 weeks, frequency, 3.3±1.1 days per week and duration 42.0±21.0 min per session. Significant and clinically important reductions in BMI, fat mass and per cent body fat were observed in aerobic versus control comparisons (BMI, mean, 95% CI -1.0, 1.4 to −0.6; fat mass -2.1, –3.3 to −1.0 kg; per cent fat -1.5, –2.2 to −0.9%) and combined aerobic and strength versus control comparisons (BMI -0.7, –1.4 to −0.1; fat mass -2.5, –4.1 to −1.0 kg; per cent fat, -2.2, –3.2 to −1.2%). A significant reduction in per cent fat was also found for strength vs control comparisons (-1.3,–2.5 to −0.1%). Combined aerobic and strength training was ranked first for improving both fat mass (kg) and per cent body fat while aerobic exercise was ranked first for improving BMI.ConclusionsAerobic and combined aerobic and strength training are associated with improvements in adiposity outcomes in overweight and obese children and adolescents.PROSPERO registration numberCRD42017073103.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Exercise and adiposity in overweight and obese children and adolescents: a systematic review with network meta-analysis of randomised trials

Kelley

Pate

2019

BMJ Open

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“…Specifically, whilst some have shown significant increases in peak V O 2 (V O 2peak ) (Owens et al 1999;Gutin et al 2002;Carrel et al 2005;Walther et al 2009), others have reported no change (Gutin et al 1995;Youssef et al 2015). Although differences in the duration, intensity and/or type of exercise programme employed may contribute to this discrepancy, it may also be attributable to differences in baseline fitness levels of the participants, which have been shown to be inversely related to the magnitude of training-induced improvements (Eliakim et al 1996;Mandigout et al 2001).…”

Section: Introductionmentioning

confidence: 93%

The influence of a six-week, high-intensity games intervention on the pulmonary oxygen uptake kinetics in prepubertal obese and normal-weight children

McNarry

Lambrick

Westrupp

et al. 2015

Appl. Physiol. Nutr. Metab.

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The pulmonary oxygen uptake response is deleteriously influenced by obesity in prepubertal children, as evidenced by a slower phase II response. To date, no studies have investigated the ability of an exercise intervention to ameliorate this. The objective of the study was to investigate the influence of a 6-week, high-intensity, games-orientated intervention on the oxygen uptake kinetic response of prepubertal obese and normal-weight children during heavy-intensity exercise. Thirteen normal-weight and 15 obese children participated in a twice-weekly exercise intervention involving repeated bouts of 6-min high-intensity, games-orientated exercises followed by 2 min of recovery. Sixteen normal-weight and 11 obese children served as a control group. At baseline and post-intervention, each participant completed a graded-exercise test to volitional exhaustion and constant work-rate, heavy-intensity exercise. Post-intervention, obese children demonstrated a reduced phase II τ (pre-intervention: 30 ± 8 cf. post-intervention: 24 ± 7 s), mean response time (pre-intervention: 50 ± 10 cf. post-intervention: 38 ± 9 s) and phase II amplitude (pre-intervention: 1.51 ± 0.30 cf. post-intervention: 1.34 ± 0.27 L·min(-1)). No changes were evident in the normal-weight children. In conclusion, the present findings demonstrate that a 6-week, high-intensity intervention can have a significant positive impact on the dynamic oxygen uptake response of obese prepubertal children.

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“…In terms of overweight/obese individuals though, the available evidence on the role of regular CVE training is limited and contradicting. Specifically, Youssef et al [193] demonstrated that a 3-month multivariate CVE programme prevented the exercise-induced lipid peroxidation and inflammation in overweight/obese girls, possibly via an improvement in body composition. In contrast, Kelly et al [194] reported previously that 8 weeks of CVE training failed to induce any alteration in levels of adipokines (C-reactive protein, interleukin 6, tumor necrosis factor alpha, adiponectin, leptin, and resistin), and oxidative stress markers (8-isoprostane) in overweight children.…”

Section: Regular Cardiovascular Exercise Trainingmentioning

confidence: 99%

Exercise-Induced Regulation of Redox Status in Cardiovascular Diseases: The Role of Exercise Training and Detraining

et al. 2019

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Although low levels of reactive oxygen species (ROS) are beneficial for the organism ensuring normal cell and vascular function, the overproduction of ROS and increased oxidative stress levels play a significant role in the onset and progression of cardiovascular diseases (CVDs). This paper aims at providing a thorough review of the available literature investigating the effects of acute and chronic exercise training and detraining on redox regulation, in the context of CVDs. An acute bout of either cardiovascular or resistance exercise training induces a transient oxidative stress and inflammatory response accompanied by reduced antioxidant capacity and enhanced oxidative damage. There is evidence showing that these responses to exercise are proportional to exercise intensity and inversely related to an individual's physical conditioning status. However, when chronically performed, both types of exercise amplify the antioxidant defense mechanism, reduce oxidative stress and preserve redox status. On the other hand, detraining results in maladaptations within a time-frame that depends on the exercise training intensity and mode, as high-intensity training is superior to low-intensity and resistance training is superior to cardiovascular training in preserving exercise-induced adaptations during detraining periods. Collectively, these findings suggest that exercise training, either cardiovascular or resistance or even a combination of them, is a promising, safe and efficient tool in the prevention and treatment of CVDs.

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Aerobic Training Suppresses Exercise-Induced Lipid Peroxidation and Inflammation in Overweight/Obese Adolescent Girls

Cited by 18 publications

References 0 publications

Exercise and adiposity in overweight and obese children and adolescents: a systematic review with network meta-analysis of randomised trials

Exercise and adiposity in overweight and obese children and adolescents: a systematic review with network meta-analysis of randomised trials

The influence of a six-week, high-intensity games intervention on the pulmonary oxygen uptake kinetics in prepubertal obese and normal-weight children

Exercise-Induced Regulation of Redox Status in Cardiovascular Diseases: The Role of Exercise Training and Detraining

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