Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men

Abstract

Little is known about the effect of exercise training on the expression of adiponectin receptor genes in peripheral blood mononuclear cells (PBMCs). In this study, we investigated the effects of aerobic training on the expression of AdipoR1 and AidpoR2 mRNAs in PBMCs, whole body insulin sensitivity, and circulating adiponectins in men. Thirty young men were randomly assigned to either a control (n=15) or an exercise (n=15) group. Subjects assigned to the exercise group underwent a 12-week jogging and/or running programme on a motor-driven treadmill at an intensity of 60%-75% of the age-based maximum heart rate with duration of 40 minutes per session and a frequency of 5 days per week. Two-way mixed ANOVA with repeated measures was used to test any significant time-by-group interaction effects for the measured variables at p=0.05. We found significant time-by-group interaction effects for waist circumference (p=0.001), VO2max (p<0.001), fasting insulin (p=0.016), homeostasis model assessment for insulin resistance (HOMA-IR) (p=0.010), area under the curve (AUC) for insulin response during the 75-g oral glucose tolerance test (p=0.002), high-molecular weight (HMW) adiponectin (p=0.016), and the PBMC mRNA levels of AdipoR1 (p<0.001) and AdipoR2 (p=0.001). The exercise group had significantly increased mRNA levels of AdipoR1 and AdipoR2 in PBMCs, along with increased whole body insulin sensitivity and HMW adiponectin, decreased waist circumference, and increased VO2max compared with the control group. In summary, the current findings suggest that exercise training modulates the expression of AdipoR1 and AdipoR2 mRNAs in PBMCs, implying that manipulation of the expression of these genes could be a potential surrogate for lifestyle intervention-mediated improvements of whole body insulin sensitivity and glucose homeostasis.

Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill

“…Overall, these observations imply some perturbations in cardiovascular function at the Bayview site. Nevertheless, increased anti-inflammatory adiponectin levels [ 27 ], and decreased haptoglobin the major hemoglobin binding protein associated with Bayview site exposures, support activation of some compensatory mechanisms [ 31 , 40 , 41 , 47 ].…”

Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms

“…Plasma adiponectin levels were negatively correlated with triglyceride and low-density lipoprotein cholesterol (LDL-C), but positively correlated with high-density lipoprotein cholesterol (HDL-C) levels in clinical trials [17,18]. Similarly to HDL-C its level increases after physical exertion [19].…”

Complex interaction of adiponectin-mediated pathways on cancer treatment: a novel therapeutic target

“…That said, if well targeted, these tests could help early diagnosis, aid post-operative recovery, and initiate APN modulatory therapy It has been shown that a Mediterranean-type diet, reduction in body weight, and exercise can increase circulating APN levels [189,216] . Furthermore, aerobic exercise was shown to increase expression of AdipoR1 and AdipoR2 in young men [217] . Therefore, using programmes that promote weight loss and a healthy diet in parallel with new APN promoting agents may enable more favourable outcome.…”