Aerobic Training Increases Expression Levels of SIRT3 and PGC-1α in Skeletal Muscle of Overweight Adolescents Without Change in Caloric Intake

Vargas-Ortiz, Katya; Pérez-Vázquez, Victoriano; Díaz-Cisneros, Francisco José; Figueroa, Arturo; Jiménez-Flores, Lizbeth M; Rodriguez-DelaRosa, Gustavo; Macias, Maciste H.

doi:10.1123/pes.2014-0112

Cited by 30 publications

(41 citation statements)

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“…As evidence, treadmill running increases SIRT3 expression in soleus an plantaris muscles in rats (Hokari et al, 2010), and transgenic mice that overexpress SIRT3 in skeletal muscle exhibit improved treadmill running performance and a higher percentage of slow oxidative muscle fibers (Lin et al, 2014). Moreover, aerobic exercise training results in an increase in SIRT3 expression in skeletal muscle in overweight human adolescents (Vargas-Ortiz et al, 2015). As with SIRT1, SIRT3 is an NAD + -dependent enzyme, it is likely that energy states that elevate NAD + levels increase SIRT3 activity.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

et al. 2016

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The impact of mitochondrial protein acetylation status on neuronal function and vulnerability to neurological disorders is unknown. Here we show that the mitochondrial protein deacetylase SIRT3 mediates adaptive responses of neurons to bioenergetic, oxidative and excitatory stress. Cortical neurons lacking SIRT3 exhibit heightened sensitivity to glutamate-induced calcium overload and excitotoxicity, and oxidative and mitochondrial stress; AAV-mediated Sirt3 gene delivery restores neuronal stress resistance. In models relevant to Huntington’s disease and epilepsy, Sirt3−/− mice exhibit increased vulnerability of striatal and hippocampal neurons, respectively. SIRT3 deficiency results in hyperacetylation of several mitochondrial proteins including superoxide dismutase 2 and cyclophilin D. Running wheel exercise increases the expression of Sirt3 in hippocampal neurons, which is mediated by excitatory glutamatergic neurotransmission and is essential for mitochondrial protein acetylation homeostasis and the neuroprotective effects of running. Our findings suggest that SIRT3 plays pivotal roles in adaptive responses of neurons to physiological challenges and resistance to degeneration.

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Section: Discussionmentioning

confidence: 99%

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

et al. 2016

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“…; Vargas‐Ortiz et al. ). It is well established that acute aerobic exercise increases pgc‐1α mRNA expression (Pilegaard et al.…”

Section: Introductionmentioning

confidence: 98%

“…; Vargas‐Ortiz et al. ). In rat skeletal muscle, LRP130 gene and protein expression are elevated in response to swimming for 7 days (Vechetti‐Junior et al.…”

Section: Introductionmentioning

confidence: 98%

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The effect of acute and chronic sprint-interval training on LRP130, SIRT3, and PGC-1α expression in human skeletal muscle

et al. 2016

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This study examined changes in LRP130 gene and protein expression in response to an acute bout of sprint‐interval training (SIT) and 6 weeks of SIT in human skeletal muscle. In addition, we investigated the relationships between changes in LRP130, SIRT3, and PGC‐1α gene or protein expression. Fourteen recreationally active men (age: 22.0 ± 2.4 years) performed a single bout of SIT (eight, 20‐sec intervals at ~170% of VO 2peak work rate, separated by 10 sec of rest). Muscle biopsies were obtained at rest (PRE) and 3 h post‐exercise. The same participants then underwent a 6 week SIT program with biopsies after 2 (MID) and 6 (POST) weeks of training. In response to an acute bout of SIT, PGC‐1α mRNA expression increased (284%, P < 0.001); however, LRP130 and SIRT3 remained unchanged. VO 2peak and fiber‐specific SDH activity increased in response to training (P < 0.01). LRP130, SIRT3, and PGC‐1α protein expression were also unaltered following 2 and 6 weeks of SIT. There were no significant correlations between LRP130, SIRT3, or PGC‐1α mRNA expression in response to acute SIT. However, changes in protein expression of LRP130, SIRT3, and PGC‐1α were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle. Future studies should investigate other exercise protocols known to increase PGC‐1α and SIRT3 protein, like longer duration steady‐state exercise, to identify if LRP130 expression can be altered in response to exercise.

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“…Skeletal muscle can be increased through exercise and other physical activities. Increasing the percentage of skeletal muscle means that the body can consume energy more easily, which in turn makes it less likely that energy will be stored as fat [34]. These markers may be useful for measuring physical change over the long term [35,36].…”

Section: Discussionmentioning

confidence: 99%

Nutritional Support Team Intervention for Patients with Mandibular Fracture Treated by Intermaxillary Fixation

Kondo¹,

Horie²,

Ohmuro³

et al. 2017

J Trauma Treat

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The objective of this study was to investigate the effectiveness of nutrition support teams (NSTs) for oral injuries in patients with mandible fracture treated by intermaxillary fixation (IMF). The participants included 25 patients who were treated for mandibular fracture by IMF with NST intervention, who were used as the primary study group, and 25 patients treated without NST intervention, who were used prospectively as a control group. Decrease of body weight of these groups was compared. During the NST intervention, the patients in the study group were encouraged to freely engage in mild exercise. In the primary study group, nutrition sufficiency ratios, body weight, serum markers (albumin Alb, hemoglobin Hb, C-reactive protein CRP), grip strength and body composition parameters (triceps skinfold thickness, mid-arm muscle circumference, body fat, subcutaneous fat, skeletal muscle) were then measured. The study group was then subdivided into two groups based on whether their grip strength increased or decreased during the NST intervention, and the data were compared between sub-groups. The body weight loss (kg and %) of patients with NST intervention was significantly lower than that of patients without NST intervention. In the primary study group, significant decrease of Alb and CRP, and significant increase of energy sufficiency was found. The body weight loss was significantly higher during the NST waiting period than during the weekly NST active period. Furthermore, the body weight loss of patients with increased grip strength was significantly lower than that of patients with decreased grip strength.

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Aerobic Training Increases Expression Levels of SIRT3 and PGC-1α in Skeletal Muscle of Overweight Adolescents Without Change in Caloric Intake

Cited by 30 publications

References 0 publications

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

The effect of acute and chronic sprint-interval training on LRP130, SIRT3, and PGC-1α expression in human skeletal muscle

Nutritional Support Team Intervention for Patients with Mandibular Fracture Treated by Intermaxillary Fixation

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