Aerobic Training Effect on Blood S-Klotho Levels in Coronary Artery Disease Patients

Saghiv, Moran S.; Sherve, Chris; Ben‐Sira, David; Sagiv, Michael; Goldhammer, Ehud

doi:10.4172/2155-9880.1000464

Cited by 10 publications

(10 citation statements)

References 22 publications

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“…As all subjects trained at their individual submaximal heart rate optimum and the variance in VO2-VT change was kept in a relatively small range. In line with our differential effects between groups, other studies already revealed the impact of exercise in human with Klotho levels being elevated in trained and healthy subjects compared to untrained subjects (Saghiv et al, 2016). A missing main effect of αKL between groups in our study is likely due to a lack of power as indicated by the high variance of αKL changes in the control group.…”

Section: Discussionsupporting

confidence: 85%

Serum α-Klotho levels correlate with episodic memory changes related to cardiovascular exercise in older adults

Becke

Maaß

Kreutz

et al. 2020

Preprint

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Aerobic exercise is a potential life-style intervention to delay cognitive decline and neurodegeneration. Elevated serum levels of the anti-aging protein α-Klotho (αKL) are a potential mediating factor of exercise benefits on cognition. Here, we examined in older adults how exercise-related changes of αKL levels in serum relate to changes in cerebral blood flow (CBF), hippocampal volumes and episodic memory. We analyzed data from a previously published intervention study in which forty cognitively healthy subjects were pseudo-randomly assigned to either a cardiovascular exercise group (treadmill training, n=21) or control group (indoor progressive-muscle relaxation/stretching, n=19). 3-Tesla gadolinium perfusion imaging was used to track hippocampal CBF changes and high resolution 7-Tesla-T1-images were used to track hippocampal volume changes. Changes in episodic memory performance were measured using the complex figure test (CFT). Longitudinal changes were compared between groups and analyzed with a multiple linear regression approach. CFT and hippocampal volume changes significantly predicted changes in serum αKL levels. For CFT, this effect was found in the exercise but not the control group. Collectively the data suggest that αKL level increases induced by exercise can be associated with improved hippocampal function in older adults.

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Section: Discussionsupporting

confidence: 85%

Serum α-Klotho levels correlate with episodic memory changes related to cardiovascular exercise in older adults

Becke

Maaß

Kreutz

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…With that said, S-Klotho is a biomarker of aging and anti-aging alike, dependent on the extent of gene expression. 32,33 Thus, this study starts to shade light on the connection between partial sleep deprivation and aging/anti-aging represented via S-Klotho concentration under certain conditions. Sleep deprivation (acute and/or chronic) is well documented as an influence of function and performance in both healthy and clinical populations, across sex and age to different extents.…”

Section: Discussionmentioning

confidence: 99%

“…31 Prior studies show improvements in aerobic capacity, exercise tolerance, and power output influence the levels of circulating S-Klotho for the better. 32,33 To the best of the authors' knowledge, no prior published data exists as to the influence of partial (less than 40hours of lack of sleep) and/or full sleep deprivation (more than 40hours of lack of sleep) on S-Klotho in women and/or during and after an exercise test of any sort. Thus, the aim of this study was to investigate the influences of partial sleep deprivation (20hours of lack of sleep) on S-Klotho concentration (pg•mL -¹).…”

Section: Introductionmentioning

confidence: 99%

The effects of partial sleep deprivation and the sub-maximal NDKS exercise testing protocol on S-Klotho and hemodynamic responses in women

Sciamama-Saghiv¹,

Welch²,

Goldhammer³

et al. 2019

SMDIJ

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Purpose: The purpose of the study was to examine the influences of partial sleep deprivation on young healthy trained women's responses to the sub-maximal NDKS exercise testing protocol. Methods: 32females 20.4±1.67 years of age, volunteered to participate in this study. Subjects underwent two sub-maximal NDKS exercise tests, once after 7-8 hours of sleep, and once after staying awake for 20hours. S-Klotho, blood pressure, heart rate, fasting blood glucose, and lactate were obtained at baseline, immediate-post, and post a dynamic recovery of 15minutes. Results: S-Klotho at baseline was 422.09±32.62(pg•mL-¹). Significant differences were found between conditions regarding immediate-post S-Klotho concentration (547.18±51.75 vs 501.15±73.33 (pg•mL-¹), respectively, p ≤ 0.01). Significant differences were found between conditions regarding post-recovery S-Klotho concentration (443.31±35.66 vs 471.48±52.84(pg•mL-¹), respectively, p ≤ 0.01). Conclusion: While not all comparisons for data obtained were significantly different, subjects had impaired responses while partially sleep deprived. In addition, partial sleep deprivation influenced S-Klotho concentrations for the worst while compared to non-sleep deprivation.

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“…With that said, S-Klotho is a biomarker of aging and anti-aging alike, dependent on the extent of gene expression. 34,35 Thus, this study starts to shade light on the connection between partial sleep deprivation and aging/anti-aging represented via S-Klotho concentration under certain conditions. Sleep deprivation (acute and/or chronic) is well documented as an influencer of function and performance in both healthy and clinical populations, across sex, gender, and age to different extents.…”

Section: Discussionmentioning

confidence: 99%

“…33 Increases in aerobic capacity, power output, and exercise tolerance increase circulating S-Klotho levels for the better. 34,35 To the best of the authors' knowledge, no prior published data exists as to the influences of partial sleep deprivation (less than 40hours of lack of sleep) on S-Klotho in men during and after a maximal exercise test of any sort. Thus, the aim of this study was to investigate the influences of partial sleep deprivation (20hours of lack of sleep) and a maximal Nustad, Dressler, Kobes, Saghiv (NDKS) exercise test on S-Klotho concentration (pg•mL -¹), heart rate (bpm), blood pressure (mmHg), and maximal oxygen uptake (mL•Kg -1 •min -1 ) in young, healthy, and trained men.…”

Section: Introductionmentioning

confidence: 99%

The effects of partial sleep deprivation and the maximal ndks exercise testing protocol on s-klotho, maximal oxygen uptake, and hemodynamic responses in young men

Sciamama-Saghiv¹,

Welch²,

Goldhammer³

et al. 2019

SMDIJ

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Purpose: The purpose of the study was to examine the influences of partial sleep deprivation on young healthy trained men's responses to the maximal NDKS exercise testing protocol. Methods: 33 males 21.2±2.31 years of age, volunteered to participate in this study. Subjects underwent two maximal NDKS exercise tests, once after 7-8hours of sleep, and once after staying awake for 20hours. S-Klotho, blood pressure, and heart rate were obtained at baseline, immediate-post, and post a dynamic recovery of 15minutes. Oxygen uptake was measured throughout exercise. Results: Significant differences were found between S-Klotho values at baseline and immediate-post of PSD and NPSD (463.31±64.18vs 651.17±70.81 pg•mL-¹, F(1,65) = 33.45, p = 0.01 and 463.31±64.18vs 727.14±81.3 pg•mL-¹, F(1,65) = 38.06, p = 0.01 respectively). Significant differences were found between conditions regarding PSD immediate-post S-Klotho concentration and that of NPSD (651.17±70.81 vs 727.14±80.3 pg•mL-¹, respectively, F(1,65) = 14.648, p = 0.02). Significant differences were found between conditions regarding baselinepost-recovery S-Klotho concentration and PSD(463.31±64.18 vs 522.68±51.98 pg•mL-¹, respectively, F(1,65) = 12.96, p-0.03). Significant differences were found between immediate-post S-Klotho values and postrecovery (PSD: 651.17±70.81 vs 522.68±51.98 pg•mL-¹, F(1,65) = 31.2, p = 0.03) and (NPSD: 727.14±80.3 vs 513.41±55.24 pg•mL-¹, F(1,65) = 34.2, p = 0.02). Conclusion: Partial sleep deprivation induced multiple negative significant differences in S-Klotho concentrations and in some cases, hemodynamic responses as well. Oxygen uptake was significantly lower while partially sleep deprived.

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Aerobic Training Effect on Blood S-Klotho Levels in Coronary Artery Disease Patients

Cited by 10 publications

References 22 publications

Serum α-Klotho levels correlate with episodic memory changes related to cardiovascular exercise in older adults

Serum α-Klotho levels correlate with episodic memory changes related to cardiovascular exercise in older adults

The effects of partial sleep deprivation and the sub-maximal NDKS exercise testing protocol on S-Klotho and hemodynamic responses in women

The effects of partial sleep deprivation and the maximal ndks exercise testing protocol on s-klotho, maximal oxygen uptake, and hemodynamic responses in young men

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