“…Many reports documented crocin ability to restore the induced damage to males' reproductive function by different harmful conditions like diabetes (Khorasani, Ahangarpour, & Khorsandi, 2021), nicotine exposure (Sefidgar et al, 2019),Busulfan induced adverse effects on male fertility parameters ,electromagnetic field (Vafaei, Motejaded, & Ebrahimzadeh-Bideskan, 2020), toxic drugs (Bakhtiary et al, 2014), genotoxic and cytotoxic herbicide of male germ cells (Kamali et al, 2020),testicular toxicity induced with chemotherapeutic agents (Mesbahzadeh et al, 2021;Davoodi et al, 2022) and oxidative stress (Domínguez-Rebolledo et al, 2010;).…”