Aerobic interval training increases peak oxygen uptake more than usual care exercise training in myocardial infarction patients: a randomized controlled study

Moholdt, Trine; Aamot, Inger Lise; Granøien, Ingrid; Gjerde, Lisbeth; Myklebust, Gitte; Walderhaug, Liv; Brattbakk, L; Hole, Torstein; Graven, Torbjørn; Stølen, Tomas; Amundsen, Brage H.; Mølmen-Hansen, Harald Edvard; Støylen, Asbjørn; Wisløff, Ulrik; Slørdahl, Stig A.

doi:10.1177/0269215511405229

Cited by 149 publications

(230 citation statements)

References 32 publications

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“…In smaller studies, HIIT protocols have a clear benefit to MICT protocols. 3,32,60 In all three studies, O2 uptake/aerobic capacity was significantly higher in the HIIT participant subgroups. Additionally Wisløff and colleagues found that HIIT was…”

Section: Role Of Exercise Intensitymentioning

confidence: 79%

“…31 Similarly, Moholdt and colleagues evaluated differences in oxygen (O2) uptake and HRQoL between facility-based and home-based CR and found no difference between groups in either O2 uptake and HRQoL. 32 A meta-analysis of 17 RCTs that included 2172 patients found no significant differences in mortality, major acute CVD events, exercise capacity, and most other markers of CV health when comparing home-based versus center-based CR. Significant differences were noted in center-based participants with respect to improvements in cholesterol and blood pressure.…”

Section: Modes Of Delivering Etmentioning

confidence: 99%

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Impact of cardiac rehabilitation and exercise training programs in coronary heart disease

Kachur

Chongthammakun

Lavie

et al. 2017

Progress in Cardiovascular Diseases

127

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Section: Role Of Exercise Intensitymentioning

confidence: 79%

Section: Modes Of Delivering Etmentioning

confidence: 99%

Impact of cardiac rehabilitation and exercise training programs in coronary heart disease

Kachur

Chongthammakun

Lavie

et al. 2017

Progress in Cardiovascular Diseases

127

View full text Add to dashboard Cite

“…It must be noted, however, that the HIIT protocols employed by studies for clinical populations 29,33,62,[140][141][142][143][144] have generally been modified to be less strenuous for greater tolerance and applicability.…”

Section: Safety Issues/clinical Perspectivesmentioning

confidence: 99%

High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in the Prevention/Management of Cardiovascular Disease

Hussain

Macaluso

Pearson

2016

Cardiology in Review

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“…Such beneficial effects of AET on impaired skeletal muscle due to cardiovascular diseases have been reported for many years (1, 17, 27, 34), including important contributions from our group (4, 8, 9, 11); however, the optimal exercise intensity to elicit maximal outcomes is still a matter of debate among clinicians and researchers. Although moderate-intensity AET is undoubtedly a safe approach and known to improve ventricular function, skeletal muscle, and exercise capacity in patients with HF, recent studies suggest that high-intensity AET, achieved by interval training, promotes superior outcomes for cardiac patients (35,60), including additional gains in cardiac function and aerobic capacity, which is the single best predictor of cardiovascular mortality (37). Nevertheless, a systematic comparison between the effects of moderate-intensity and high-intensity AET on skeletal muscle adaptations in cardiovascular diseases has never been reported in humans or animal models.…”

mentioning

confidence: 99%

High- versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats

Moreira

Bechara

Bozi

et al. 2013

Journal of Applied Physiology

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Moreira JB, Bechara LR, Bozi LH, Jannig PR, Monteiro AW, Dourado PM, Wisløff U, Brum PC. High-versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats. J Appl Physiol 114: 1029 -1041, 2013. First published February 21, 2013 doi:10.1152/japplphysiol.00760.2012.-Poor skeletal muscle performance was shown to strongly predict mortality and long-term prognosis in a variety of diseases, including heart failure (HF). Despite the known benefits of aerobic exercise training (AET) in improving the skeletal muscle phenotype in HF, the optimal exercise intensity to elicit maximal outcomes is still under debate. Therefore, the aim of the present study was to compare the effects of highintensity AET with those of a moderate-intensity protocol on skeletal muscle of infarcted rats. Wistar rats underwent myocardial infarction (MI) or sham surgery. MI groups were submitted either to an untrained (MI-UNT); moderate-intensity (MI-CMT, 60% V O2 max); or matched volume, high-intensity AET (MI-HIT, intervals at 85% V O2 max) protocol. High-intensity AET (HIT) was superior to moderate-intensity AET (CMT) in improving aerobic capacity, assessed by treadmill running tests. Cardiac contractile function, measured by echocardiography, was equally improved by both AET protocols. CMT and HIT prevented the MI-induced decay of skeletal muscle citrate synthase and hexokinase maximal activities, and increased glycogen content, without significant differences between protocols. Similar improvements in skeletal muscle redox balance and deactivation of the ubiquitin-proteasome system were also observed after CMT and HIT. Such intracellular findings were accompanied by prevented skeletal muscle atrophy in both MI-CMT and MI-HIT groups, whereas no major differences were observed between protocols. Taken together, our data suggest that despite superior effects of HIT in improving functional capacity, skeletal muscle adaptations were remarkably similar among protocols, leading to the conclusion that skeletal myopathy in infarcted rats was equally prevented by either moderate-intensity or high-intensity AET. atrophy; heart failure; proteasome; oxidative stress SKELETAL MUSCLE ABNORMALITIES in systemic diseases have been described for decades (9, 14, 29, 52), including in heart failure (HF). Capillary rarefaction, switch from type I (oxidative) to type II (glycolytic) fibers, impaired metabolism, and skeletal muscle atrophy have been shown in human and experimental models of HF (14,21,29,43,49,52). This maladaptation seems to impair skeletal muscle performance, which was proposed as the main determinant of exercise capacity in patients with HF (21,32,40). Additionally, skeletal muscle loss was shown to be an independent predictor of mortality in HF (3).Recent efforts by researchers have identified possible intracellular mechanisms underlying the skeletal muscle abnormalities in cardiovascular diseases, and promising targets such as metabolic enzymes, calcium handling-related proteins, antioxidant scavengers, and in...

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Aerobic interval training increases peak oxygen uptake more than usual care exercise training in myocardial infarction patients: a randomized controlled study

Abstract: AIT increased peak oxygen uptake more than the usual care rehabilitation provided to MI patients by Norwegian hospitals.

Cited by 149 publications

References 32 publications

Impact of cardiac rehabilitation and exercise training programs in coronary heart disease

Impact of cardiac rehabilitation and exercise training programs in coronary heart disease

High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in the Prevention/Management of Cardiovascular Disease

High- versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats

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