Aerobic Interval Training Elicits Different Hemodynamic Adaptations Between Heart Failure Patients with Preserved and Reduced Ejection Fraction

Fu, Tieh‐Cheng; Yang, Ning-I; Wang, Chao-Hung; Cherng, Wen‐Jin; Chou, Szu-Ling; Pan, Tai‐Long; Wang, Jong‐Shyan

doi:10.1097/phm.0000000000000312

Cited by 85 publications

(96 citation statements)

References 29 publications

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“…Sixteen weeks of exercise training increased PEAKV O 2 , ventilatory anaerobic threshold, 6-min walk distance, and physical quality-of-life scores in patients with HFpEF (124). A recent trial showed an improvement in diastolic function, with reduction of the E/E' ratio, in HFpEF group patients subjected to aerobic interval training, compared with general health care groups (72). These studies suggest an important role for exercise in HFpEF patient's life, which must be considered in the treatment of this syndrome.…”

Section: Sild Ena Fil (Re La X Stu Dy)mentioning

confidence: 96%

Myocardial reverse remodeling: how far can we rewind?

Gonçalves-Rodrigues

Leite‐Moreira

Falcão-Pires

2016

American Journal of Physiology-Heart and Circulatory Physiology

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Heart failure (HF) is a systemic disease that can be divided into HF with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF). HFpEF accounts for over 50% of all HF patients and is typically associated with high prevalence of several comorbidities, including hypertension, diabetes mellitus, pulmonary hypertension, obesity, and atrial fibrillation. Myocardial remodeling occurs both in HFrEF and HFpEF and it involves changes in cardiac structure, myocardial composition, and myocyte deformation and multiple biochemical and molecular alterations that impact heart function and its reserve capacity. Understanding the features of myocardial remodeling has become a major objective for limiting or reversing its progression, the latter known as reverse remodeling (RR). Research on HFrEF RR process is broader and has delivered effective therapeutic strategies, which have been employed for some decades. However, the RR process in HFpEF is less clear partly due to the lack of information on HFpEF pathophysiology and to the long list of failed standard HF therapeutics strategies in these patient's outcomes. Nevertheless, new proteins, protein-protein interactions, and signaling pathways are being explored as potential new targets for HFpEF remodeling and RR. Here, we review recent translational and clinical research in HFpEF myocardial remodeling to provide an overview on the most important features of RR, comparing HFpEF with HFrEF conditions.

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Section: Sild Ena Fil (Re La X Stu Dy)mentioning

confidence: 96%

Myocardial reverse remodeling: how far can we rewind?

Gonçalves-Rodrigues

Leite‐Moreira

Falcão-Pires

2016

American Journal of Physiology-Heart and Circulatory Physiology

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“…Numerous studies have assessed changes in resting cardiac function following ET in patients with HFrEF [26][27][28][29][30][31][32][33][34] (Table 2). However, these studies have reported conflicting data about the ability of exercise training to induce favourable changes in left ventricle (LV) volumes, and ejection fraction (EF).…”

Section: Exercise Training and Cardiac Function In Hfref And Hfpef Exmentioning

confidence: 99%

Mechanisms of the Improvement in Peak VO2 With Exercise Training in Heart Failure With Reduced or Preserved Ejection Fraction

Tucker

Lijauco

Hearon

et al. 2018

Heart, Lung and Circulation

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“…This increase in muscle vascular function was the only significant predictor of VO 2 peak. Interestingly, this phenomenon was not seen in HFrEF patients, for whom improved cardiac output was the only predictor of VO 2 peak [142]. …”

Section: Exercise Training: the Silver Lining On The Cloudmentioning

confidence: 99%

Targeting Endothelial Function to Treat Heart Failure with Preserved Ejection Fraction: The Promise of Exercise Training

Gevaert

Lemmens

Vrints

et al. 2017

Oxidative Medicine and Cellular Longevity

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Although the burden of heart failure with preserved ejection fraction (HFpEF) is increasing, there is no therapy available that improves prognosis. Clinical trials using beta blockers and angiotensin converting enzyme inhibitors, cardiac-targeting drugs that reduce mortality in heart failure with reduced ejection fraction (HFrEF), have had disappointing results in HFpEF patients. A new “whole-systems” approach has been proposed for designing future HFpEF therapies, moving focus from the cardiomyocyte to the endothelium. Indeed, dysfunction of endothelial cells throughout the entire cardiovascular system is suggested as a central mechanism in HFpEF pathophysiology. The objective of this review is to provide an overview of current knowledge regarding endothelial dysfunction in HFpEF. We discuss the molecular and cellular mechanisms leading to endothelial dysfunction and the extent, presence, and prognostic importance of clinical endothelial dysfunction in different vascular beds. We also consider implications towards exercise training, a promising therapy targeting system-wide endothelial dysfunction in HFpEF.

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Aerobic Interval Training Elicits Different Hemodynamic Adaptations Between Heart Failure Patients with Preserved and Reduced Ejection Fraction

Cited by 85 publications

References 29 publications

Myocardial reverse remodeling: how far can we rewind?

Myocardial reverse remodeling: how far can we rewind?

Mechanisms of the Improvement in Peak VO2 With Exercise Training in Heart Failure With Reduced or Preserved Ejection Fraction

Targeting Endothelial Function to Treat Heart Failure with Preserved Ejection Fraction: The Promise of Exercise Training

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