Aerobic glycolysis is important for zebrafish larval wound closure and tail regeneration

Ca, Scott; Carney, Thomas J.; Amaya, Enrique

doi:10.1111/wrr.13050

Cited by 13 publications

(7 citation statements)

References 58 publications

(141 reference statements)

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“…The metabolic demands at a site of damage and repair are hugely increased to drive cell proliferation and other repair processes. Just as in rapidly growing cancer where the Warburg effect switches metabolic pathways from the citric acid cycle and oxidative phosphorylation to anaerobic glycolysis, it seems that injury and repair can also lead to a metabolic shift in cells ( Sinclair et al, 2021 ; Scott et al, 2022 ).…”

Section: Altering Metabolism At the Wound Sitementioning

confidence: 99%

Parallel repair mechanisms in plants and animals

Byatt

Martin

2023

Disease Models &Amp; Mechanisms

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All organisms have acquired mechanisms for repairing themselves after accidents or lucky escape from predators, but how analogous are these mechanisms across phyla? Plants and animals are distant relatives in the tree of life, but both need to be able to efficiently repair themselves, or they will perish. Both have an outer epidermal barrier layer and a circulatory system that they must protect from infection. However, plant cells are immotile with rigid cell walls, so they cannot raise an animal-like immune response or move away from the insult, as animals can. Here, we discuss the parallel strategies and signalling pathways used by plants and animals to heal their tissues, as well as key differences. A more comprehensive understanding of these parallels and differences could highlight potential avenues to enhance healing of patients’ wounds in the clinic and, in a reciprocal way, for developing novel alternatives to agricultural pesticides.

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Section: Altering Metabolism At the Wound Sitementioning

confidence: 99%

Parallel repair mechanisms in plants and animals

Byatt

Martin

2023

Disease Models &Amp; Mechanisms

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“…Beyond cell types and signals, fluorescent metabolic sensors have helped decipher the role that glycolysis and other metabolic pathways play in wound healing. For example, work from Enrique Amaya's lab has used a FRET-based sensor for lactate levels to show that these increase transiently after larval zebrafish fin fold amputation, with lactate inhibition leading to an impairment in wound contraction (Scott et al, 2022). Other FRET-based sensors that can measure changes in tension have also been generated in zebrafish (Lagendijk et al, 2017), but these tools have yet to be used under regenerative or reparative conditions.…”

Section: Coordination Is the Key During Wound Repair And Tissue Regen...mentioning

confidence: 99%

Pathway to Independence: the future of developmental biology

Agarwal,

Cadart,

Fort

et al. 2023

Development

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In 2022, Development launched its Pathway to Independence (PI) Programme, aimed at supporting postdocs as they transition to their first independent position. We selected eight talented researchers as the first cohort of PI Fellows. In this article, each of our Fellows provides their perspective on the future of their field. Together, they paint an exciting picture of the current state of and open questions in developmental biology.

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“…Metabolic conversion from oxidative phosphorylation to aerobic glycolysis therefore likely serves a key role in regeneration. Studies have previously shown that metabolic transformation to glycolysis is an inevitable initial event during blastema formation and tail regeneration in zebrafish after amputation ( 49 , 50 ). During this process, cells undergo epithelial-mesenchymal transition and dedifferentiation.…”

Section: Tissue Damage and Microenvironmental Changementioning

confidence: 99%

“…During this process, cells undergo epithelial-mesenchymal transition and dedifferentiation. Inhibiting glycolysis leads to the failure of tail regeneration ( 49 , 50 ). In a zebrafish cardiac regeneration model, glycolysis transfer has been found to be concentrated in the vicinity of damaged tissues ( 51 ).…”

Section: Tissue Damage and Microenvironmental Changementioning

confidence: 99%

Dedifferentiation and in vivo reprogramming of committed cells in wound repair (Review)

Guo

Yang

et al. 2022

Mol Med Rep

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Accumulating evidence has shown that cell dedifferentiation or reprogramming is a pivotal procedure for animals to deal with injury and promote endogenous tissue repair. Tissue damage is a critical factor that triggers cell dedifferentiation or reprogramming in vivo. By contrast, microenvironmental changes, including the loss of stem cells, hypoxia, cell senescence, inflammation and immunity, caused by tissue damage can return cells to an unstable state. If the wound persists in the long-term due to chronic damage, then dedifferentiation or reprogramming of the surrounding cells may lead to carcinogenesis. In recent years, extensive research has been performed investigating cell dedifferentiation or reprogramming in vivo, which can have significant implications for wound repair, treatment and prevention of cancer in the future. The current review summarizes the molecular events that are known to drive cell dedifferentiation directly following tissue injury and the effects of epigenetic modification on dedifferentiation or reprogramming in vivo. In addition, the present review explores the intracellular mechanism of endogenous tissue repair and its relationship with cancer, which is essential for balancing the risk between tissue repair and malignant transformation after injury.

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Aerobic glycolysis is important for zebrafish larval wound closure and tail regeneration

Abstract: By combining a genetically encoded lactate FRET sensor with chemical inhibitors, we demonstrate a critical role for the Warburg effect and metabolic reprogramming during zebrafish wound closure and tail regeneration..

Cited by 13 publications

References 58 publications

Parallel repair mechanisms in plants and animals

Parallel repair mechanisms in plants and animals

Pathway to Independence: the future of developmental biology

Dedifferentiation and in vivo reprogramming of committed cells in wound repair (Review)

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