Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice

Kim, Youn Ju; Kim, Hye Jin; Kim, Tae Hyun; Kim, Do Hyun; Jang, Su; Go, Hye Sun; Lee, Wonjun; Seong, Je Kyung

doi:10.1016/j.metabol.2022.155178

Cited by 13 publications

(7 citation statements)

References 57 publications

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“…For example, the GW29-e0223 LncRNA gene chip analyzes the effect of simultaneous exercise on aortic insulin resistance 24 ; exercise can reduce insulin resistance in type 2 diabetes by mediating the lncRNA MALAT1/microRNA-382-3p/ resistin axis 25 . These studies suggest that exercise can exert multiple physiological modulatory effects on related metabolic diseases through significantly increased the diet of mice in the high-fat exercise group, the experimental results showed that body weight, liver triglyceride content, and total serum cholesterol were still significantly reduced after the exercise intervention, which contributed to the improvement of hepatic steatosis 44 . The same results were shown in the study performed by Emmanuel Denou et al 45 .…”

Section: Discussionmentioning

confidence: 89%

Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA

Tian

et al. 2022

Sci Rep

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The role of aerobic exercise in preventing and improving non-alcoholic fatty liver has been widely established. SRA is a long non-coding RNA, which has received increasing attention due to its important role in lipid metabolism. However, it is unclear whether aerobic exercise can prevent and treat hepatic lipid accumulation via SRA. The mice were randomly divided into four groups as follows, normal control group, normal aerobic exercise group, high-fat diet group (HFD), and high-fat diet plus aerobic exercise (8 weeks, 6 days/week, 18 m/min for 50 min, 6% slope) group (HAE). After 8 weeks, the mice in the HAE group showed significant improvement in hepatic steatosis. Body weight as well as blood TC, LDL-C, and liver TG levels were significantly lower in the HAE group than in the HFD group. Compared with the HFD group, the expression of SRA was markedly suppressed and the expression of ATGL was significantly increased in the HAE group. Additionally, the JNK/P38 signaling was inhibited, the pro-inflammatory factors were down-regulated, and the anti-inflammatory factor was increased. In addition to this, the same results were shown in experiments with overexpression of SRA. The results of this study provided new support for aerobic exercise to improve hepatic lipid metabolism via lncRNA.

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Section: Discussionmentioning

confidence: 89%

Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA

Tian

et al. 2022

Sci Rep

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“…Studies also show that increasing bilirubin levels decreases liver fat content and reduces oxidative stress in obese mice, improving adiposity and blood glucose ( 19 – 22 ). Other work has shown that aerobic exercise protects the liver and cardiometabolic health and adipose tissue remodeling under metabolic stress ( 23 ). These adaptations might be linked to glucose and fatty acid metabolism during exercise, which points to well-controlled crosstalk between the liver and skeletal muscle, exchanging substrates and maintaining metabolic homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Cutting edge concepts: Does bilirubin enhance exercise performance?

Flack

Vı́tek

Fry

et al. 2023

Front. Sports Act. Living

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Exercise performance is dependent on many factors, such as muscular strength and endurance, cardiovascular capacity, liver health, and metabolic flexibility. Recent studies show that plasma levels of bilirubin, which has classically been viewed as a liver dysfunction biomarker, are elevated by exercise training and that elite athletes may have significantly higher levels. Other studies have shown higher plasma bilirubin levels in athletes and active individuals compared to general, sedentary populations. The reason for these adaptions is unclear, but it could be related to bilirubin's antioxidant properties in response to a large number of reactive oxygen species (ROS) that originates from mitochondria during exercise. However, the mechanisms of these are unknown. Current research has re-defined bilirubin as a metabolic hormone that interacts with nuclear receptors to drive gene transcription, which reduces body weight. Bilirubin has been shown to reduce adiposity and improve the cardiovascular system, which might be related to the adaption of bilirubin increasing during exercise. No studies have directly tested if elevating bilirubin levels can influence athletic performance. However, based on the mechanisms proposed in the present review, this seems plausible and an area to consider for future studies. Here, we discuss the importance of bilirubin and exercise and how the combination might improve metabolic health outcomes and possibly athletic performance.

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“…Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases around the world and becoming a serious public health problem [1][2][3][4]. It is characterized by the existence of steatosis in over 5 % of hepatocytes and results in a wide range of metabolic alterations from hepatic lipotoxicity and inflammation to more severe nonalcoholic steatohepatitis (NASH) with striking fibrosis in liver [5][6][7][8]. Exercise is a currently effective strategy to treat NAFLD [6,[9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…It is characterized by the existence of steatosis in over 5 % of hepatocytes and results in a wide range of metabolic alterations from hepatic lipotoxicity and inflammation to more severe nonalcoholic steatohepatitis (NASH) with striking fibrosis in liver [5][6][7][8]. Exercise is a currently effective strategy to treat NAFLD [6,[9][10][11][12][13]. However, the underlying mechanisms of the positive effects of exercise on the alleviation of NAFLD are still incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice

Zhu

Chen

et al. 2022

Metabolism

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Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice

Cited by 13 publications

References 57 publications

Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA

Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA

Cutting edge concepts: Does bilirubin enhance exercise performance?

Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice

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