Aerobic Exercise and Its Effect on Oxytocin Level and Labor Progression

Irianti, Setyorini; Ginandjar, A B; Krisnadi, Sofie Rifayani; Effendi, Jusuf Sulaeman; Nataprawira, D.; Gandamihardja, Supriadi

doi:10.1088/1757-899x/180/1/012177

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…After adjusting for substantial potential confounders, we found that women who were administered oxytocin during labour had lower CRF and flexibility than women who did not need this drug. CRF is related to the ability of the circulatory and respiratory systems to supply oxygen to the tissues and to eliminate fatigue products [26] and it has been positively associated with endogenous oxytocin levels in pregnant women [27]. Moreover, labour is a strenuous process that often has a long duration and usually produces a huge physiological fatigue [23].…”

Section: Discussionmentioning

confidence: 99%

Association of Self-Reported Physical Fitness during Late Pregnancy with Birth Outcomes and Oxytocin Administration during Labour—The GESTAFIT Project

García

Marín-Jiménez

Romero‐Gallardo

et al. 2021

IJERPH

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We explored (a) the associations between self-reported maternal physical fitness and birth outcomes; (b) whether self-reported maternal physical fitness (PF) is related to the administration of oxytocin to induce or stimulate labour. Pregnant women from the GESTAFIT project randomized controlled trial (n = 117) participated in this prospective longitudinal study. Maternal physical fitness was assessed through the International Fitness Scale at the 34th gestational week. Maternal and neonatal birth outcomes and oxytocin administration were collected from the obstetric medical records. Umbilical arterial and venous cord blood gas were analysed immediately after birth. Self-reported overall fitness, cardiorespiratory fitness, muscular strength and flexibility were not related to any maternal and neonatal birth outcomes (all p > 0.05). Greater speed-agility was associated with a more alkaline arterial (p = 0.04) and venous (p = 0.02) pH in the umbilical cord blood. Women who were administered oxytocin to induce or stimulate labour reported lower cardiorespiratory fitness (p = 0.013, Cohen’s d = 0.55; 95% confidence interval (CI): 0.14, 0.93) and flexibility (p = 0.040, Cohen´s d = 0.51; 95% CI: 0.09, 0.89) compared to women who were not administered oxytocin. Greater maternal physical fitness during pregnancy could be associated with better neonatal birth outcomes and lower risk of needing oxytocin administration.

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Section: Discussionmentioning

confidence: 99%

Association of Self-Reported Physical Fitness during Late Pregnancy with Birth Outcomes and Oxytocin Administration during Labour—The GESTAFIT Project

García

Marín-Jiménez

Romero‐Gallardo

et al. 2021

IJERPH

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“…Prolonged moderate-intensity exercise, in contrast to acute and intensive exercise, was proven to reduce gastric mucosal damage and alleviate the stress response with reductions in the circulating levels of cortisol (Cheng et al 2000b;Bahadir et al 2016;Shephard, 2017). Although exercise was found to increase serum oxytocin levels (Irianti et al 2017) and peripheral administration of oxytocin was reported to exert an anti-ulcer activity (Asad et al 2001b), the role of oxytocin in the protective effect of exercise on gastric ulcer has not yet been evaluated. Our current data revealed that exercise-induced alleviation of gastric damage is partially dependent on the activity of oxytocin receptors.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, elevation of endogenous oxytocin levels under psychosocial stress was suggested to be associated with increased cortisol reactivity in humans, verifying its role as a stress-reducing hormone that aids the recovery from sustained stress (Heinrichs et al 2009;Engert et al 2016). Regular aerobic exercise, which has been reported to elevate plasma oxytocin levels in humans (Landgraf et al 1982;Irianti et al 2017), is universally acknowledged as an advantageous tool in stress reduction and for a better mood (Hamer et al 2012). Similarly, exercise training in rodents has suppressed anxiety and enhanced oxytocin levels in the blood, cardiac and brain tissues (Gutkowska et al 2007;Yüksel et al 2019), implying that the beneficial effects of exercise could involve oxytocin-mediated mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Regular moderate exercise alleviates gastric oxidative damage in rats via the contribution of oxytocin receptors

Tamer

Üçem

Buke

et al. 2020

The Journal of Physiology

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Key points A moderate level of exercise has beneficial effects for the prevention of gastric ulcers. Although regular aerobic exercise was shown to elevate serum oxytocin levels and exogenously administered oxytocin exerts an anti‐ulcer activity, the role of endogenous oxytocin in the gastroprotective effects of exercise has not yet been elucidated. We showed that increased anxiety and oxidative gastric damage induced by gastric ulcers were reversed in pre‐exercised rats, while reduced hypothalamic oxytocin expression and decreased myenteric oxytocin receptor expression due to gastric ulcers were abolished by exercise. We also reported that the blockade of oxytocin receptors exaggerated gastric damage in exercised rats with ulcers. Our data establish that endogenous oxytocin is the key mediator in the beneficial effects of regular physical activity in alleviating gastric injury. Abstract Exercise increases serum oxytocin levels and exogenous oxytocin exerts an anti‐ulcer activity; but the role of oxytocin in the protective effects of exercise against gastric ulcers has not yet been evaluated. This study was designed to investigate the impact of regular swimming exercise on oxidative gastric injury, and the role of oxytocin receptor activity in the anxiolytic and anti‐inflammatory actions of exercise. Adult Wistar albino rats of both sexes performed swimming exercise (30 min/day, 5 days) or stayed sedentary. At the end of the 6‐week exercise/sedentary protocol, rats were injected intraperitoneally with atosiban (0.1 mg/kg/day) or saline for 4 days. On the 5th day, under anaesthesia, acetic acid (ulcer) or saline (sham) was applied onto the gastric serosa and the treatments were continued. On the 9th day, anxiety levels were determined; gastric blood flow was measured, and blood, gastric and brain tissues were obtained. Induction of ulcers in sedentary rats increased anxiety and serum corticosterone levels; but reduced gastric blood flow and resulted in apoptosis and oxidative gastric damage with increased cytokine expressions. However, when ulcers were induced in pre‐exercised rats, behavioural and biochemical alterations due to gastric damage were reversed. The inhibition of oxytocin receptors by atosiban exaggerated pro‐inflammatory cytokine expressions and gastric lipid peroxidation in the stomachs of exercised rats with ulcers. When rats had regularly exercised prior to ulcer induction, reductions in the immunolabelling of hypothalamic oxytocin and myenteric oxytocin receptors were abolished, suggesting that exercise‐induced alleviation of gastric injury may involve the reversal of down‐regulated oxytocinergic activity.

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