Aerobic Exercise Alters Analgesia and Neurotrophin-3 Synthesis in an Animal Model of Chronic Widespread Pain

Sharma, Neena; Ryals, Janelle M.; Gajewski, Byron; Wright, Douglas E.

doi:10.2522/ptj.20090168

Cited by 62 publications

(63 citation statements)

References 55 publications

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“…The obtained results from this study showed that increased activity in the form of moderate endurance exercise can improve neuropathic pain responses in mechanical allodynia and thermal hyperalgesia. This result is consistent with some studies suggesting the significant effects of exercise training on neuropathic pain responses in various pain models (11,15). Conversely, some studies have failed to confirm the effects of exercise training on improvement of neuropathic pain (17).…”

Section: Discussionsupporting

confidence: 81%

“…At first, during the orientation phase and in order to habituate to laboratory conditions (treadmill and manipulation exercises), the animals were given exercise on a treadmill, 5 days a week for 10 -15 minutes at a speed of 10 m/min. The rats were exposed to behavioral testing for 3 days (2 times for each testing) for adaptation to behavioral tests (15). 2 weeks after induction of diabetes and by re -running pain behavioral tests, as well as ensuring incidence of neuropathic pain in diabetic groups, the endurance exercise protocol was then carried out for 6 weeks (14).…”

Section: Methodsmentioning

confidence: 99%

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Effect of Endurance Exercise Training on Kinesin - 5 and Dynein Motor Proteins in Sciatic Nerves of Male Wistar Rats with Diabetic Neuropathy

Golbar

Gharekhanlu

Kordi

et al. 2018

Int J Sport Stud Hlth

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Objectives: Diabetic neuropathy is a type of nerve disorders caused by diabetes which leads to disruptions of axonal transports and exercise can result in its improvement. However, mechanisms and the impact of exercise in these disruptions are not fully understood. So, the purpose of this research is to investigate the effect of endurance exercise on contents of Kinesin -5 and Dynein motor proteins in sciatic nerves of male Wistar rats with diabetic neuropathy. Methods:A number of Twenty -four male Wistar rats were randomly placed in four groups of six each: diabetes control, diabetes exercise, healthy control, and healthy exercise. Intraperitoneal injection of streptozotocin (STZ, 45 mg/Kg) was used for induction of diabetes. Moderate -endurance exercise protocol was performed for 6 weeks, two weeks after injection of STZ and diabetic neuropathy was proven by mechanical allodynia and thermal hyperalgesia tests. 24 hours after the last training session, the rats were dissected and their sciatic nerves were extracted. The contents of Kinesin -5 and Dynein motor proteins were examined with enzymatic method (ELISA).Results: Moderate -endurance exercise significantly improves mechanical allodynia and thermal hyperalgesia in rats. A significant correlation was observed between mechanical allodynia and thermal hyperalgesia with resting levels of blood glucose (r = 0.68, p = 0.001, r = 0.82, p = 0.001, respectively). A significant increase was observed in contents of Kinesin -5 and Dynein motor proteins in diabetes control compared with healthy control and diabetes exercise groups (p < 0.05). A significant increase was obtained in contents of Kinesin -5 and Dynein motor proteins in healthy exercise group compared to healthy control group (p < 0.05). Conclusions:The results demonstrate that one of the possible factors involved in axonal transport dysfunction in diabetic neuropathy can be STZ induced upregulation of Kinesin -5 and Dynein motor proteins in diabetic rats. Endurance exercise as a nonmedication strategy can moderate the increase.

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Section: Discussionsupporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Effect of Endurance Exercise Training on Kinesin - 5 and Dynein Motor Proteins in Sciatic Nerves of Male Wistar Rats with Diabetic Neuropathy

Golbar

Gharekhanlu

Kordi

et al. 2018

Int J Sport Stud Hlth

View full text Add to dashboard Cite

show abstract

“…Most of these studies started exercise at the time of injury or after development of hyperalgesia and show a reversal of the hyperalgesia with as little as a single treatment (3,33,51,58). However, Kuphal and colleagues show that 7 days of exercise prior to induction of inflammatory pain with formalin or 2 wk of exercise prior to induction of neuropathic pain attenuated the development of pain behaviors.…”

Section: Exercise Effects In Animal Models Of Painmentioning

confidence: 99%

Regular physical activity prevents development of chronic pain and activation of central neurons

Sluka

O’Donnell

Danielson

et al. 2013

Journal of Applied Physiology

162

168

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“…This concept is at the foundation of the biopsychosocial model of pain. 11 Experimental evidence suggests that pain due to early-stage (regional) central sensitization 38,62 versus late-stage (widespread) central sensitization 57 may be modulated in distinct ways. QST may help stage nociceptive processing and thereby improve efficacy in patient care.…”

Section: Clinical Application Of Quantitative Sensory Testing In Muscmentioning

confidence: 99%

“…38,57,62 QST may be an ideal clinical outcome measure for identifying somatosensory patterns typically associated with certain stages of altered nociception and for documenting pain modulation. 39 Finally, identification of nociceptive mechanisms and quantitative sensory changes in patients with chronic musculoskeletal dysfunction may help explain some previously controversial clinical examination findings.…”

Section: Quantitative Sensory Testingmentioning

confidence: 99%

Interpreting Joint Pain: Quantitative Sensory Testing in Musculoskeletal Management

Courtney

Emerson

Lowry

et al. 2010

Journal of Orthopaedic & Sports Physical Therapy

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Synopsis Pain is a common complaint among clients seeking physical therapy services, yet interpretation of associated sensory changes can be difficult for the clinician. Musculoskeletal injury typically results in nociceptive pain due to noxious stimuli of the damaged muscle or joint tissues. However, with progression from acute to chronic stages, altered nociceptive processing can give rise to an array of sensory findings. Specifically, patients with chronic joint injury may present with signs and symptoms typically associated with neuropathic injury, due to changes in nociceptive processing. Clinical presentation may include expansion of hyperalgesia into adjacent and remote areas, allodynia, dysesthesias, and perceptual deficits. Quantitative sensory testing (QST) may provide an objective method of examining sensation and, thereby, of recognizing potential changes in the nociceptive pathways. The purpose of this paper is to provide an overview of altered nociceptive processing and somatosensory changes that may occur following a musculoskeletal injury without associated neural injury. Recommendations are made on clinical uses of quantitative sensory testing in orthopaedic physical therapy practice, and supporting clinical and laboratory evidence are presented. Examples related to joint injury are discussed, specifically, osteoarthritis of the knee and low back pain. Quantitative sensory testing may be a useful clinical tool to aid clinical decision making and for determination of prognosis. J Orthop Sports Phys Ther 2010;40(12):818–825. doi:10.2519/jospt.2010.3314

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Aerobic Exercise Alters Analgesia and Neurotrophin-3 Synthesis in an Animal Model of Chronic Widespread Pain

Abstract: This is the first study demonstrating the effect of exercise on deep tissue mechanical hyperalgesia in a rodent model of pain and providing a possible molecular basis for exercise training in reducing muscular pain.

Cited by 62 publications

References 55 publications

Effect of Endurance Exercise Training on Kinesin - 5 and Dynein Motor Proteins in Sciatic Nerves of Male Wistar Rats with Diabetic Neuropathy

Effect of Endurance Exercise Training on Kinesin - 5 and Dynein Motor Proteins in Sciatic Nerves of Male Wistar Rats with Diabetic Neuropathy

Regular physical activity prevents development of chronic pain and activation of central neurons

Interpreting Joint Pain: Quantitative Sensory Testing in Musculoskeletal Management

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