Aerobic capacity in adults with various congenital heart diseases

Fredriksen, Per Morten; Veldtman, Gruschen; Hechter, Sloane; Therrien, Judith; Chen, Alice; Warsi, Mohammed Ali; Freeman, Marc; Liu, Peter; Siu, Samuel C.; Thaulow, Erik; Webb, Gary D.

doi:10.1016/s0002-9149(00)01364-3

Cited by 187 publications

(127 citation statements)

References 17 publications

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“…22,23 Objective exercise testing after atrial repair reveals diminished aerobic capacity with limited cardiac output because of reduced stroke volume and attenuated heart rate response. 21,24 In our study, multivariable regression analyses reveal that repair type was significant for all but 2 CHQ concepts, with atrial switch being associated with lower scores than ASO. Although no significant differences were found between scores for children with Mustard and Senning by univariable comparison, Mustard repair was independently associated with lower scores on several CHQ concepts.…”

Section: Discussionmentioning

confidence: 51%

Quality of Life of Children After Repair of Transposition of the Great Arteries

Culbert

Ashburn²,

Cullen-Dean³

et al. 2003

Circulation

109

104

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Background— We sought to assess quality of life of children with transposition of the great arteries (TGA) enrolled during transition in management strategy from atrial to arterial switch operation. Methods and Results— Neonates enrolled by the Congenital Heart Surgeons Society in a prospective study of TGA between 1985 and 1989 were eligible. A Child Health Questionnaire was sent for completion by the child between February and June 2000. Data were compared with published normative values. Child Health Questionnaires were completed by 306 of 708 survivors at a mean age of 13±1 years. Diagnosis included TGA (n=202, 66%), TGA/ventricular septal defect (VSD) (n=84, 27%), and TGA/VSD/pulmonary stenosis (n=20, 7%). Repair type was arterial switch (n=189, 62%), atrial switch (n=105, 34%; Senning=58, Mustard=47), or Rastelli (n=12, 4%). Children with TGA scored significantly higher than published norms in all categories except self-esteem. TGA/VSD/pulmonary stenosis was associated with lower scores than TGA and TGA/VSD in physical functioning ( P =0.002), general health perceptions ( P =0.012), and mental health ( P =0.048). Arterial repair was associated with higher scores than atrial or Rastelli repair in physical functioning ( P <0.001), pain ( P =0.004), mental health ( P =0.019), self-esteem ( P =0.004), and general health perceptions ( P <0.001). By multivariable analyses, the most common independent factors impacting scores were repair type, perfusion parameters, and gender. Conclusions— Quality of life and health status as perceived by children 11 to 15 years after TGA repair is excellent when compared with published normative data and is better after arterial switch operation than after atrial repair.

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Section: Discussionmentioning

confidence: 51%

Quality of Life of Children After Repair of Transposition of the Great Arteries

Culbert

Ashburn²,

Cullen-Dean³

et al. 2003

Circulation

109

104

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“…Overall, most will have some degree of exercise intolerance that can affect physical functioning. [75][76][77][78][79][80][81] The chronic nature of their exercise limitations may lead to discrepancies with absolute exercise tolerance and perceived quality of life. [82][83][84] However, a recent study has found the severity of exercise intolerance in adults with congenital heart disease correlated with an increased risk for hospitalization and death 85 similar to that for adults with heart failure due to other causes.…”

Section: Congenital Heart Diseasementioning

confidence: 99%

Indications for Heart Transplantation in Pediatric Heart Disease

Canter¹,

Shaddy²,

Bernstein³

et al. 2007

Circulation

252

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Background— Since the initial utilization of heart transplantation as therapy for end-stage pediatric heart disease, improvements have occurred in outcomes with heart transplantation and surgical therapies for congenital heart disease along with the application of medical therapies to pediatric heart failure that have improved outcomes in adults. These events justify a reevaluation of the indications for heart transplantation in congenital heart disease and other causes of pediatric heart failure. Methods and Results— A working group was commissioned to review accumulated experience with pediatric heart transplantation and its use in patients with unrepaired and/or previously repaired or palliated congenital heart disease (children and adults), in patients with pediatric cardiomyopathies, and in pediatric patients with prior heart transplantation. Evidence-based guidelines for the indications for heart transplantation or retransplantation for these conditions were developed. Conclusions— This evaluation has led to the development and refinement of indications for heart transplantation for patients with congenital heart disease and pediatric cardiomyopathies in addition to indications for pediatric heart retransplantation.

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“…54 However, improved oxygen uptake during exercise is only 1 parameter of the effect of training and cannot be used alone to determine whether the main goals of exercise have been achieved. 59 Beyond improved oxygen consumption and tolerance of physical activity, physical training of children and adolescents can also result in decreased withdrawal and somatic complaints.…”

Section: Exercise and Athleticsmentioning

confidence: 99%