Aerobic bacteriological profile and their antibiotic susceptibility in Chronic Suppurative Otitis Media in patients from Mangalore, Karnataka State

Shetty, Anil; Shetty, Akhil

doi:10.4103/0972-1282.134454

Cited by 10 publications

(5 citation statements)

References 7 publications

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“…This study showed predominance of gram-negative bacteria (54.45%) as also seen in other studies by Kumar H et al [8] Although most of the studies reported Pseudomonas as most common isolate, [8][9][10][11] but in our studyStaphylococcus aureus (n=32, 31.68%) was the most common isolate followed by Pseudomonas aeruginosa (n=24, 23.76%) as also reported by Prakash M et al [12] Other isolates were E. coli, Klebsiellapneumoniae, CONS, Proteus mirabilis, Enterococcus spp, Acinetobacter spp. diphtheroids and Citrobacterfruendi.…”

Section: Discussionsupporting

confidence: 84%

“…[9] Overall this study has reported greater resistance pattern among the bacterial isolates than other studies. [8][9][10][11][12] Among the flouroquinolones, sensitivity of levofloxacin (75%) was much greater than ciprofloxacin (67.32%). Among the cephalosporins, ceftazidime was most active against 80% of Pseudomonas and with overall sensitivity for 71% isolates.…”

Section: Discussionmentioning

confidence: 99%

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Changing Trends of Antibiogram Profile in Patients With Community Acquired Chronic Otitis Media in a Tertiary Care Hospital

Chakraborty¹,

Dhara²,

Ghosh³

et al. 2014

jemds

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INTRODUCTION: Chronic otitis media (COM) is one among the commonest otological diseases encountered in otorhinolaryngological practice and attending ENT OPD especially among the lower socioeconomic strata of society. AIMS: This study was carried out to know about the aerobic bacterial flora causing COM and in-vitro antibiotic susceptibility pattern in order to scientifically guide patient management instead of relying on empirical therapy alone. MATERIALS AND METHODS: This study included 100 patients of community acquired COM attending ENT OPD of a tertiary care level hospital. After proper sample collection by sterile aural swabs, they were immediately sent to the microbiology laboratory for processing by aerobic culture, isolation and identification following standard recommended methods and antibiotic susceptibility tests were done by Kirby-Bauer disc diffusion methods as per Clinical and Laboratory Standards Institute (CLSI) guidelines. RESULTS: Out of 100 cases of COM, microbiological culture yielded 101 bacterial isolates from 90 patients and 4 fungal isolates (3 isolates of Candida albicans and 1 isolate of Aspergillusfumigatus) from 4 patients. Polymicrobial infections were seen in 11.11% patients. In this study Staphylococcus aureus (31.68%) was the commonest isolate followed by Pseudomonas aeruginosa (23.76%). Other common bacterial isolates were E.coli, Klebsiellapneumoniae, coagulase negative Staphylococcus (CONS), Proteus mirabilis in descending order. Piperacillin-tazobactum was the most sensitive drug (85.45%) among the gram-negative bacteria followed by meropenem (81.81%), amikacin (76.36%) and levofloxacin (74.54%). Gram positive bacteria showed 100% sensitivity to vancomycin and 93.47% sensitivity to linezolid. For Methicillin resistant Staphylococcus aureus (MRSA) isolates ciprofloxacin, cotrimoxazole, tetracycline, linezolid and vancomycin were found to have good activity. CONCLUSION: This study suggests that the common etiological agents for community acquired COM were Staphylococcus aureus and Pseudomonas aeruginosa. Also correct choice of anti-bacterial agents by proper microbial sensitivity tests is necessary for effective therapy as the bacterial isolates are gradually becoming resistant to commonly prescribed antibiotics.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Changing Trends of Antibiogram Profile in Patients With Community Acquired Chronic Otitis Media in a Tertiary Care Hospital

Chakraborty¹,

Dhara²,

Ghosh³

et al. 2014

jemds

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“…15 In another study conducted by Shetty et al was also pseudomonas aeruginosa (37.8%), staph aureus (30.49), streptococcus species (3.6%) which also correlates with our study. 16 These are similar to findings of our study. In this study most common finding on CT imaging was ossicular erosion (38.33%), followed by facial canal erosion (18.33%), followed by tegmen erosion (16.33%) and mastoid cortex erosion (16.33%).…”

Section: Discussionsupporting

confidence: 92%

A systematic review of complications of attico-antral type of chronic suppurative otitis media in our region

Khadkekar

Benny

Gujrathi

et al. 2021

Int J Otorhinolaryngol Head Neck Surg

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Background: Chronic suppurative otitis media (CSOM) is a very common disease that should be carefully treated, as severe complications can develop. Despite the significantly decrease incidence of CSOM-related complications since the introduction of antibiotics, this clinical problem has not been eliminated.Methods: This was an observational study conducted including 60 cases of attico-antral type of CSOM and its complications. Detailed study of determinants of attico-antral type of CSOM and its complications were studied. The various options in the management of disease and its complications with their outcomes were studied. Results: Majority of study participants belonged to lower socio-economic group. intra-temporal complications were most common complications and most of the patients required canal wall down surgery. Majority patients had complete recovery of the disease without recurrence during 3 months of follow-up.Conclusions: Our study concluded majority of the patients belonged to the low socioeconomic status. It was also clear from the study that timely intervention in the form of early diagnosis and administration of proper treatment resulted in complete recovery of majority of patients.

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“…Linezolid and Vancomycin were found 100% efficacious against gram-positive bacteria followed by Imipenem (83 to 96.3%) and Gentamicin (81.4 to 83%) and similar efficacy has also been reported by others. 2 , 17 , 18 , 21 Until now, Vancomycin, Linezolid and Imipenem are among less frequently prescribed antibiotics for CSOM, still preserving their excellent efficacy. This conservation should be continued to combat emergence of resistance.…”

Section: Discussionmentioning

confidence: 99%

Microbiology of Chronic Suppurative Otitis Media: An update from a Tertiary Care Hospital in Bangladesh

et al. 2021

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Objectives: Chronic suppurative otitis media is a major cause of acquired hearing impairment, especially in children of developing countries. The study sought to explore the bacteriological profile and their antimicrobial susceptibility among patients of chronic suppurative otitis media from a tertiary care hospital in Bangladesh. Methods: A cross sectional microbiological study was conducted at the Department of Microbiology, Rajshahi Medical College, Bangladesh from January to December 2019. Aural swabs were collected aseptically from clinically suspected patients irrespective of age and gender attending the ear, nose and throat outpatient department of Rajshahi Medical College Hospital. Aerobic bacterial culture was done and isolates were identified through standard bacteriological identification scheme. Antimicrobial susceptibility testing of isolates was done by modified Kirby-Bauer disk diffusion method following Clinical and Laboratory Standards Institute guidelines. Results: Of 96 swabs, culture yielded a total of 73 bacterial isolates from 68(70.8%) culture-positive plates including 63 (65.6%) unimicrobial and 5 (5.2%) polymicrobial (mixed growth of a pair of bacteria) growths. Frequency distribution revealed, 40(55%) gram-negative and 33(45%) gram-positive bacteria with Staphylococcus aureus was the leading isolate (37%) followed by Pseudomonas aeruginosa (31.5%), Escherichia coli (13.7%), coagulase-negative Staphylococcus (8.2%), Klebsiella pneumoniae (5.5%) and Proteus spp. (4.1%). Gram-positive bacteria were found to be highly susceptible (100%) to Linezolid and Vancomycin followed by Imipenem (83 to 96.3%), while moderate to high resistance (44 to 67%) was observed against Ciprofloxacin, Ceftriaxone, Ceftazidime, Amoxicillin/Clavulanate and Clindamycin. For gram-negative bacteria, susceptibility ranged from 67 to 100% to Imipenem, 67 to 96% to Piperacillin/Tazobactam and 67 to 83% to Gentamicin, while moderate to high resistance (50 to 75%) was observed against Ciprofloxacin, Ceftriaxone, Ceftazidime and Amoxicillin/Clavulanate. Conclusion: Moderate to high level of multidrug-resistance especially to 3rd generation cephalosporins, Ciprofloxacin and Amoxicillin/Clavulanate is an alarming situation. It warns reinforcement of judicious antibiotic prescription and introduction of antibiotic stewardship program in the tertiary care hospitals. doi: https://doi.org/10.12669/pjms.37.3.3942 How to cite this:Khatun MR, Alam KMF, Naznin M, Salam MA. Microbiology of Chronic Suppurative Otitis Media: An update from a Tertiary Care Hospital in Bangladesh. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3942 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Aerobic bacteriological profile and their antibiotic susceptibility in Chronic Suppurative Otitis Media in patients from Mangalore, Karnataka State

Cited by 10 publications

References 7 publications

Changing Trends of Antibiogram Profile in Patients With Community Acquired Chronic Otitis Media in a Tertiary Care Hospital

Changing Trends of Antibiogram Profile in Patients With Community Acquired Chronic Otitis Media in a Tertiary Care Hospital

A systematic review of complications of attico-antral type of chronic suppurative otitis media in our region

Microbiology of Chronic Suppurative Otitis Media: An update from a Tertiary Care Hospital in Bangladesh

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