Aerobic and anaerobic microbiology of axillary hidradenitis suppurativa

Brook, Itzhak; Frazier, Edith H.

doi:10.1099/00222615-48-1-103

Cited by 73 publications

(59 citation statements)

References 15 publications

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“…A large variety of micro-organisms has been isolated from the lesions; the most frequently isolated pathogens are Staphylococcus aureus , Gram-negative rods [4,5,6] and anaerobic bacteria [5, 7]. Unfortunately the clinical significance of superficial and even deep bacterial sampling is very low in the clinical setting [8].…”

Section: Introductionmentioning

confidence: 99%

Combination Therapy with Clindamycin and Rifampicin for Hidradenitis Suppurativa: A Series of 116 Consecutive Patients

Géner¹,

Canouï‐Poitrine²,

Revuz³

et al. 2009

Dermatology

225

175

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Background: Antibiotics are frequently used to treat hidradenitis suppurativa (HS); however, few data on their efficacy are available. Objective: To evaluate the efficacy of a combination of systemic clindamycin (300 mg twice daily) and rifampicin (600 mg daily) in the treatment of patients with severe HS. Methods: Patients (n = 116) who received this combination were studied retrospectively. The main outcome measure was the severity of the disease, assessed by the Sartorius score, before and after 10 weeks of treatment. Results: The Sartorius score dramatically improved at the end of treatment (median = 29, interquartile range = 14.5, vs. median = 14.5, interquartile range = 11; p < 0.001), as did other parameters of severity as well as the quality of life score. Eight patients (6.9%) stopped the treatment because of side effects. Conclusion: The combination of clindamycin and rifampicin is effective in the treatment of severe HS.

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Section: Introductionmentioning

confidence: 99%

Combination Therapy with Clindamycin and Rifampicin for Hidradenitis Suppurativa: A Series of 116 Consecutive Patients

Géner¹,

Canouï‐Poitrine²,

Revuz³

et al. 2009

Dermatology

225

175

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“…Time for complete wound healing for patients treated by excision and second intention healing varied proportionally to the extent and degree of infection of the unroofed area, with a mean of ten weeks (range, 7-17 weeks). In the patients treated by excision and skin grafting, the time until complete healing was shorter, with a mean of six (range, [3][4][5][6][7][8][9] weeks. Partial loss of the skin graft occurred in nine (37.5 percent) patients treated with this technique.…”

Section: Resultsmentioning

confidence: 99%

“…Folliculitis seems to be the most important finding in pathologic specimens of HS and it is present in up to 67 percent of the lesions. [2][3][4] The cause of glandular obstruction remains unclear. Studies about the size and distribution of the apocrine glands; the use of deodorants, talc, chemical depilation, or blade depilation 5 ; and the influence of genetic factors and alterations of the immune state are not conclusive.…”

Section: Discussionmentioning

confidence: 99%

Gluteal and Perianal Hidradenitis Suppurativa

Bocchini

Habr‐Gama

Kiss

et al. 2003

Diseases of the Colon &Amp; Rectum

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“…In a retrospective research over a period of 6 years, Brook and Frazier [29] obtained a total of 17 specimens from axillary lesions by direct percutaneous needle aspiration or during surgical drainage. They highlighted the polymicrobial nature as well as the predominance of anaerobic bacteria in axillary HS.…”

Section: Discussionmentioning

confidence: 99%

“…[27]. However, the clinical relevance of these findings in HS remains unclear: negative cultures from the surface of HS lesions are not uncommon; there is a variety of isolated organisms; infectious complications, such as cellulitis, are rare, and regional lymph nodes remain almost invariably uninvolved [27,28,29,30]. …”

Section: Introductionmentioning

confidence: 99%

Aerobic and Anaerobic Bacteriology of Hidradenitis Suppurativa: A Study of 22 Cases

Katoulis

Koumaki

Liakou

et al. 2015

Skin Appendage Disord

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Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unclear etiology. The role of bacteria in the pathogenesis of disease remains controversial. Materials and Methods: Specimens were obtained from 22 HS patients by direct percutaneous needle aspiration. The collected material was cultured in aerobic and anaerobic conditions, and sensitivity tests were performed. Results: Of the 22 patients, 32% were culture negative and 68% were culture positive. A total of 16 isolates was obtained, 14 aerobic and 2 anaerobic. Aerobic bacteria were present in 86% of the specimens, whereas only anaerobic bacteria were isolated in 7%. The predominant aerobic species were Proteus mirabilis, Staphylococcus haemolyticus and Staphylococcus lugdunensis. The isolated anaerobic bacteria were Dermacoccus nishinomiyaensis and Propionibacteriumgranulosum. Conclusion: A variety of aerobic and anaerobic bacteria was isolated from the HS lesions of our patients. In contrast to previous studies, fewer patients were found to be culture positive, and Staphylococcus aureus was isolated in only 1 of them. More studies are necessary to elucidate the controversial role of bacteria in the pathogenesis of HS.

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Aerobic and anaerobic microbiology of axillary hidradenitis suppurativa

Cited by 73 publications

References 15 publications

Combination Therapy with Clindamycin and Rifampicin for Hidradenitis Suppurativa: A Series of 116 Consecutive Patients

Combination Therapy with Clindamycin and Rifampicin for Hidradenitis Suppurativa: A Series of 116 Consecutive Patients

Gluteal and Perianal Hidradenitis Suppurativa

Aerobic and Anaerobic Bacteriology of Hidradenitis Suppurativa: A Study of 22 Cases

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