Aerobic and anaerobic bacteriology of subcutaneous abscesses

Abstract

Pus from 84 patients with subcutaneous abscesses was examined for aerobic and anaerobic bacteria: organisms were recovered from 70 (83.3 per cent). In 13 no organisms were seen in the Gram-stained smears and the cultures showed no bacterial growth. Staphylococcus aureus was the most prevalent organism (n = 44), isolated in 43 in pure culture, in marked contrast to the anaerobic organisms which almost invariably were associated with mixed cultures. All patients were treated by the primary suture method. Half of them were not given preoperative antibiotics and 3 developed bacteraemia and 1 septicaemia. Blood isolates were of S. aureus of the same phage type as pus isolates. The other patients received one infection of 300 mg of clindamycin phosphate 30 min to 1 h before surgery. From this group only one patient, with a perianal abscess, developed Escherichia coli bacteraemia. The levels of clindamycin in the abscess aspirate were inhibitory for S. aureus, bacteroides, streptococci and other Gram-positive bacteria but not for E. coli.

Safety and Efficacy of Tigecycline in Treatment of Skin and Skin Structure Infections: Results of a Double-Blind Phase 3 Comparison Study with Vancomycin-Aztreonam

“…Complicated SSSIs may be caused by gram-positive and/or gram-negative bacteria, including resistant strains (4,8,9,11,13,33). The efficacy of tigecycline (a 50-mg infusion every 12 h after an initial dose of 100 mg) was noninferior to that of V/A (a 1-g/2-g infusion every 12 h), as seen in various predefined patient populations (CE, c-mITT, ME, m-mITT populations) at the test-of-cure visit.…”

“…Organisms isolated from baseline cultures were considered to be the primary baseline isolate based on the frequency with which those organisms are identified in the particular disease state (13,(17)(18)(19)37). Safety evaluation.…”

“…The disease in patients with SSSIs has a diverse bacterial etiology, with polymicrobial cutaneous infections that often include gram-positive organisms, Pseudomonas aeruginosa, and enteric gram-negative bacilli and anaerobes (4,8,9,11,13,33). In addition, a long-standing concern with SSSIs in the hospital is the emergence of methicillin-resistant Staphylococcus aureus (MRSA) (3).…”

S3-Leitlinie: Analabszess

“…In der Regel findet sich erwartungsgemäß eine Mischflora aus Darmkeimen (v. a. E. coli, Bakteroides) und Hautkeimen (Staphylococcus aureus) [10,29,111]. Dieses wird auch von aktuellen Publikationen bestätigt [16].…”

S3-Leitlinie: Analabszess

“…Die Zahl der Drüsen ist bei Männern höher als bei Frauen [63]. In einer aktuellen Studie [2] [14,36,125]). Dieses wird auch von aktuellen Publikationen bestä-tigt [22].…”