Aerobacteriology of laboratories and offices: Evidence of high risk exposure to immune complex formation in Nigeria

In vitro antibacterial activity of Hibiscus rosa–sinensis flower extract against human pathogens

“…There are several reports published on antibacterial activity of different herbal extracts [18][19][20][21][22][23][24][25] . It supports the earlier investigation that the tannins isolated from the flower possess remarkable toxic activity against bacteria and may assume pharmacological importance [26][27][28][29][30][31][32][33][34][35][36][37][38] . Many antimicrobial screening studies use a relatively small number of microorganisms for testing.…”

Assessment of DNA methylation patterns in breast tumours and apparently healthy subjects in Anambra state, Nigeria

“…High-level, medium-level and low-level waste in solid, liquid and gaseous forms are released into the environment of Anambra state at discrete intervals or at a continuous basis. They may have short or long half-lives in the environment, the consequences are health hazards [9,10]. Because of improper handling and disposal of the harmful wastes materials, we are worried about the health implications and possible influences on epigenetic Mechanisms.…”

“…Thus the need to access the epigenetic status of even supposed healthy individuals. Air and water pollutions are on the fastest increase in the area [10,11].…”

Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis

“…Continuous exposure to these exogenous substances would be a source to retain pathological level of immune complexes in circulation. Due to constant exposure to many infectious agents or foreign pathogens, with continuous infection and re-infection as may occur in some developing countries [10], IC accumulation may reach a plateau, deposit on organs and constitute a great immunological risk factor to epimutagenesis.…”

“…Continuous exposure to infection as may be experienced in some developing countries [10], would enable persistent circulation of immune complexes and subsequent continual activation of immune cell and release of pro-inflammatory cytokine leading to chronic inflammation. Prolonged subclinical inflammation and associated necrotic cell death also cause release of intracellular molecules that alert the immune system to danger, evoking responses leading to epithelial regeneration, angiogenesis, proliferation, and ultimately tumorigenesis [11].…”