Aero‐Self‐Assembly of Ultrafine Gold Incorporated Silica Nanobunches for NIR‐Induced Chemo‐Thermal Therapy

Abstract

An aero‐self‐assembly to fabricate Au‐SiO2/IBU‐PLL functional nanobunches is introduced for the first time for the efficient inhibition of cell proliferation through NIR‐induced chemo‐thermal therapy. This functional nanoparticle design approach provides useful insights for improving the applica­bility of Au‐based hybrid nanoparticles for the development of smart controlled release systems.

915 nm Light‐Triggered Photodynamic Therapy and MR/CT Dual‐Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes

“…have been prepared for potential multifunctional bioprobing applications, but often involve complicated synthesis processes and cause the enlargement of the original sizes of the NPs . To realize efficient assembly of these different function modalities at the nanoscale, it usually requires the development of novel synthesis strategies, such as gas‐phase self‐assembly method, as the complementary techniques to the wet chemistry methods . As will be discussed later, the Na 0.52 YbF 3.52 :Er@SrF 2 UCNPs exhibit excellent MR/CT imaging and red UC emission properties simultaneously, which can be applied for cancer theranostics without the assistance of other function modalities.…”

“…[ 31 ] To realize effi cient assembly of these different function modalities at the nanoscale, it usually requires the development of novel synthesis strategies, such as gas-phase self-assembly method, as the complementary techniques to the wet chemistry methods. [32][33][34] As will be discussed later, the Na 0.52 YbF 3.52 :Er@SrF 2 UCNPs exhibit excellent MR/CT imaging and red UC emission properties simultaneously, which can be applied for cancer theranostics without the assistance of other function modalities. The multifunctional Na 0.52 YbF 3.52 :Er@SrF 2 UCNPs with relatively small size can be prepared using simple wet chemistry methods, which thus may be of helpful for their further applications as bioprobes.…”

Combined In Situ Spectroscopies Reveal the Ligand Ordering-Modulated Photoluminescence of Upconverting Nanoparticles

“…The luminescent inorganic nanoparticles (NPs), such as trivalent lanthanide (Ln 3+ )-doped nanoparticles, quantum dots (QDs), and noble metal NPs, have become the research hotspot in the fields ranging from displays to biological imaging and sensing. − Albeit of the outstanding physical and chemical stability of their inorganic core as compared to organic chromophores, the optical properties of the NPs are sensitive to the complicated surface chemistries such as capping ligands and solvents. − Through vibrational coupling or altering the electronic states, the surface molecules heavily influence the photoluminescence (PL) performance of the nanoparticles. − As the role of chemical variations of the capping molecules in e.g ., anchoring groups and the chain length has been extensively studied, knowledge about the influence of the physical variations of the capping ligands, especially the effect of ligand conformation on the excitation energy dissipation scheme of the NPs, is still scarce and often controversial. − One main obstacle lies in the lack of a powerful tool for characterizing the ligand conformation when surveying the ligand–NP interactions . Previously, the capping ligands of the luminescent NPs were generally probed using the conventional spectroscopy techniques such as Fourier-transform infrared (FTIR) absorption and spontaneous Raman spectroscopy.…”

Modified Aerotaxy for the Plug-in Manufacture of Cell-Penetrating Fenton Nanoagents for Reinforcing Chemodynamic Cancer Therapy

“…Motivated by the above discussions, this study designed and constructed a modified AT system through a serial connection of electrically operable aerosol dispensers and a heated flow reactor to manufacture Mn–Fe spike decorated amorphous CaCO 3 (denoted as Mn–Fe CaCO 3 (AT)) and SiO 2 (denoted as Mn–Fe CaCO 3 (AT)) nanoagents for chemodynamic cancer therapies in a single-pass, continuous configuration, unlike multistep wet chemical processes (Table S1). The modified AT used a spark plasma to ablate the transition metals (Mn and Fe) and a mechanical spray to supply amorphous biocompatible CaCO 3 and SiO 2 nanobeads as a digital manufacture platform − to generate Mn–Fe CaCO 3 and Mn–Fe SiO 2 composite precursors for the in-flight epitaxial growth of anisotropic Mn–Fe oxides (MnFe 2 O 4 ) on nanobeads. The resulting Mn–Fe CaCO 3 (AT) and Mn–Fe SiO 2 (AT) were assessed as biofunctional nanoagents for Fenton reaction-induced cancer treatment (i.e., chemodynamic therapy from hydroxyl radicals that lead to high oxidative stress in tumor cells).…”