Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast

Derf, Asma; Sharma, Ankita; Bharate, Sandip B.; Chaudhuri, Bhabatosh

doi:10.1016/j.bmcl.2018.12.028

Cited by 16 publications

(7 citation statements)

References 52 publications

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“…Bael (Aegle marmelos) is a well-known wood apple that is local, easily, and abundantly available in India. Aegeline (antioxidant alkaloid amide) and 1,3-dimethylamylamine are the dominant ingredients of A. marmelos leaves [23]. Especially, the present study encourages the exploration of novel alternative plants.…”

Section: Open Access Receivedmentioning

confidence: 64%

Performance of dye-sensitized solar cells extracted dye from wood apple leaves

et al. 2022

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In this work, wood apple leaves dye has been extracted, characterized, and examined as a potential photosensitizer for dye-sensitized solar cells (DSSCs). The dye was extracted in an ethanolic medium from the fresh wood apple leaves and characterized using thin-layer chromatography (TLC), ultraviolet-visible (UV-Vis), and Fourier transform infrared (FTIR) spectroscopy. The current density-voltage (J-V) characteristics measurements were performed on the two assembled DSSCs for 1- 22 days using fresh and seven days old extracted dye. The characterization results revealed that the extracted dye mainly contains the compound of carotenoids (neoxanthin), chlorophyll-a, chlorophyll-b, and their derivative (pheophytin) with various functional groups. The J-V characteristics of DSSCs indicate that an open-circuit voltage and short circuit current density radically decrease with increasing time, thus degrading the efficiency of cells. A degraded DSSCs suffered from high defect recombination may be induced by Mg ions migrating from chlorophyll dye into DSSC. Therefore, the extracted dye may be used for energy harvesting from the wood apple leaves.

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Section: Open Access Receivedmentioning

confidence: 64%

Performance of dye-sensitized solar cells extracted dye from wood apple leaves

et al. 2022

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“…Quercetin was shown to block tau hyperphosphorylation by upregulating adenosine monophosphate-activated protein kinase (AMPK) and inhibiting glycogen synthase kinase 3 beta (GSK3β) [57]. The secondary metabolites with reported protective effects against synucleinopathy in PD include aegeline; an alkaloid-amide from Aegle marmelos [58], curcumin [50], EGCG, ginsenosides and withanolide A (from W. somnifera). The mechanism of inhibition of α-synuclein aggregation by these compounds remains unclear, and further investigation is necessary to reach conclusive results.…”

Section: Preventing Protein Misfolding and Aggregationmentioning

confidence: 99%

Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

Sharifi‐Rad

Lankatillake

Dias

et al. 2020

JCM

172

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Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.

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“…Traffic Tom22 [135,137] Tom22 [135,139] TOM complex [136] Mdm34 [148] Vps34 [54] Vamp3 [181] Sec22 [182] AtVAMP [63] Autophagy and protein quality control Uth1 [73,183] Yme1 [184] Naa20 [185] Atg5, Atg7 [73] Sentrin [186] Protein aggregates PrP [187,188] α-synuclein [189] Proteinkinases AKT [128] PKCα [190] AKT [128] Sch9 [191] Stress responses Hsp60 [192] Hog1 [193] Trx1 [194] Fth1 [195] Tsa1 [194] Rgi1 [195] tQM [196] LePHGPx [64] AtEBP [62,65] BI-GST [60,197] sAPX [198] Energetic metabolism Qcr7, Cyc3, Cox4, Cox7, Atp4, Pet9 [161,199] Data not confirmed in [155] COX6A1 [200] OYE2 [69,201] Por1 [199] GAPDH [202] Lipid metabolism SMS1 [203] Hfd1 [184] Fah1…”

Section: Yeast Proteins Plant and Viral Proteinsmentioning

confidence: 99%

Yeast as a tool to decipher the molecular mechanisms underlying the functions of Bcl-2 family

Manon

2022

Exploration of Targeted Anti-Tumor Therapy

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The budding yeast Saccharomyces cerevisiae, a favorite model in biology, does not contain any protein of the Bcl-2 family. From initial experiments with two-hybrid systems to the heterologous expression of human Bcl-2 family members, and the characterization of several forms of yeast programmed cell death, it has however always been a powerful tool to gain information on the mechanisms of apoptosis in general and on Bcl-2 family in particular. This is a short survey of 25 years of experiments that have provided, and at times initiated, insights into the molecular mechanisms underlying the function of Bcl-2 family members.

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Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast

Cited by 16 publications

References 52 publications

Performance of dye-sensitized solar cells extracted dye from wood apple leaves

Performance of dye-sensitized solar cells extracted dye from wood apple leaves

Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

Yeast as a tool to decipher the molecular mechanisms underlying the functions of Bcl-2 family

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