Aedes aegypti larvae treated with spinosad produce adults with damaged midgut and reduced fecundity

Fernandes, Kenner Morais; Tomé, Hudson V. V.; Miranda, Franciane Rosa; Gonçalves, Wagner Gonzaga; Pascini, Tales Vicari; Serrão, José Éduardo; Martins, Gustavo Ferreira

doi:10.1016/j.chemosphere.2019.01.068

Cited by 30 publications

(23 citation statements)

References 34 publications

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“…This is a very positive point of the DMC treatment, as lower longevity contributes to the reduction of vector capacity as a whole, minimizing the disease transmission cycle. Similar results were observed with the insect growth regulator triflumuron, 54 spinosad, 55 and pyriproxyfen, at certain temperatures 34 …”

Section: Resultssupporting

confidence: 83%

Curcumin/d‐mannitol as photolarvicide: induced delay in larval development time, changes in sex ratio and reduced longevity of Aedes aegypti

Mezzacappo

Souza

Inada

et al. 2021

Pest Management Science

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BACKGROUND Resistant populations of Ae. aegypti have been a major problem in arboviruses epidemic areas, generating a strong demand for novel methods of vector control. In this regard, our group has demonstrated the use of curcumin as an efficient photoactive larvicide to eliminate Ae. aegypti larvae. This work was aimed to evaluate the Ae. aegypti (Rockefeller) development under sublethal conditions, using a curcumin/d‐mannitol (DMC) formulation. The photolarvicidal efficacy under semi‐field and field conditions (wild populations) was also analyzed, as well as the photobleaching and residual activity of DMC. RESULTS A delay in development time when larvae were exposed to sublethal concentrations of DMC was observed, followed by significant changes in sex ratio and reduction in longevity. DMC also presented a low residual activity when compared to usual larvicides, and had a substantial photolarvicidal activity against wild populations in field trials, achieving 71.3% mortality after 48 h. CONCLUSIONS Overall, these findings are of great biological importance for the process of enabling the implementation of DMC as a new product in the control of Ae. aegypti larvae, and contributes to the improvement of new plant‐based larvicides. © 2021 Society of Chemical Industry

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Section: Resultssupporting

confidence: 83%

Curcumin/d‐mannitol as photolarvicide: induced delay in larval development time, changes in sex ratio and reduced longevity of Aedes aegypti

Mezzacappo

Souza

Inada

et al. 2021

Pest Management Science

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“…The spinosad-based products in have also been tested in toxic baits and residual treatments for the control of adult mosquitoes [42,43]. Larval exposure to spinosad can have sublethal effects on the structure and function of the adult midgut and adult reproductive capacity [44,45]. Nonetheless, suitable measures should be taken to avoid the development of mosquito resistance to spinosad that has been reported in a laboratory selection study [46], and in natural populations of mosquitoes exposed to residues of spinosad used in agriculture [47].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Spinosad Granules and Lambda-Cyhalothrin Contrasts with Reduced Performance of Temephos for Control of Aedes spp. in Vehicle Tires in Veracruz, Mexico

Williams

Farfán

Mercado

et al. 2019

Insects

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The present study examined the efficacy of λ-cyhalothrin, pyriproxyfen and granular formulations of spinosad and temephos for the control of mosquito larvae present in experimental tires in Veracruz State, Mexico in the period 2015–2016. Both λ-cyhalothrin and spinosad granules provided control of larvae and pupae of Aedes aegypti, Ae. albopictus and Culex spp. in used tires in Veracruz State, Mexico, over a 9–12 week period, although numbers of Culex were low. The numbers of Aedes larvae + pupae in pyriproxyfen and temephos-treated tires were slightly less than half of the untreated control tires, probably a result the pupicidal characteristics of pyriproxyfen and possible resistance in the case of temephos. Spinosad was less harmful to predatory Toxorhynchites spp. than λ-cyhalothrin or temephos. The reduced susceptibility to temephos in Aedes populations was confirmed at five other sites in Veracruz. Public health authorities should consider incorporating spinosad as a larvicide in coastal areas at a high risk of dengue, chikungunya and Zika outbreaks in this region.

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“…It was found what was interpreted as a linear decrease of fecundity with an increasing dose of insecticide (Fig. 4a) (61).…”

Section: Biological Impact Of Insecticidesmentioning

confidence: 89%

“…A probable example of such confounding effects have been shown in Aedes aegypti larvae that were exposed to a partially lethal concentration (LC50) of an insecticide (60). Unexpectedly, it was found that surviving adults were larger and laid more eggs, which is the opposite of what was found with lower doses of the same insecticide (61). While such studies are important and ecologically relevant, they do not allow to explain the relative contribution of both the sublethal and the lethal (i.e.…”

Section: Biological Impact Of Insecticidesmentioning

confidence: 99%

Effects of sublethal doses of an insecticide on the vectorial capacity of the malaria vector Anopheles gambiae

Hauser¹

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The presence of insecticide residues in water can strongly affect the development and life-history of mosquitoes. As the toxicity usually decreases along with the concentration, it is often considered that sub-lethal doses of insecticides induce negligible effects. However, there is increasing evidence that when applied at low doses, toxic substances may induce substantial and unpredictable effects on the organisms. Since these effects may affect the ability of mosquitoes to transmit pathogens, the study of sublethal doses in the context of vector ecology is of both an eco-toxicological and an epidemiological interest. In this thesis, the malaria mosquito vector and a pyrethroid insecticide were used to experimentally assess the consequences of low doses of insecticides on several aspects of mosquito’s vectorial capacity. In the different experiments, mosquitoes were mainly – but not only – exposed at larval stage to test for possible carry-over effects on the adults. In the first four chapters, the effect of the insecticide on mosquito’s development and adult life-history traits (Chap. 2), competence for the malaria parasite (Chap. 3), immunity (Chap. 4), and oxidative state (Chap. 5) were examined. In the sixth chapter, the possibility and consequences for mosquitoes to bite through an insecticide-treated bed-net (ITN) were explored. Finally, an evolutionary approach was used to test the possibility for both the insecticide at sublethal dose and the contact with an ITN to contribute to the evolution insecticide resistance (Chap. 7). As the response of mosquitoes to the insecticide may vary following environmental conditions, the effect of larval competition was additionally assessed as a proxy for limited resources. The results and their implications for both malaria transmission and the evolution of insecticide resistance are discussed throughout the thesis. Overall, this work provides a broader understanding of the physiological, epidemiological, and evolutionary consequences of the exposure of mosquito larvae to insecticide residues, and stresses the need for a better consideration of sub-lethal doses in the field of vector-borne diseases.

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Aedes aegypti larvae treated with spinosad produce adults with damaged midgut and reduced fecundity

Cited by 30 publications

References 34 publications

Curcumin/d‐mannitol as photolarvicide: induced delay in larval development time, changes in sex ratio and reduced longevity of Aedes aegypti

Curcumin/d‐mannitol as photolarvicide: induced delay in larval development time, changes in sex ratio and reduced longevity of Aedes aegypti

Efficacy of Spinosad Granules and Lambda-Cyhalothrin Contrasts with Reduced Performance of Temephos for Control of Aedes spp. in Vehicle Tires in Veracruz, Mexico

Effects of sublethal doses of an insecticide on the vectorial capacity of the malaria vector Anopheles gambiae

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