Advertising of antihypertensive medicines and prescription sales in Australia

Vitry, Agnès; Lai, Yu-Kai

doi:10.1111/j.1445-5994.2009.01909.x

Cited by 6 publications

(8 citation statements)

References 9 publications

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“…Drugs that interfere with the function of the renin-angiotensin system (RAS) are the most commonly prescribed class of agents for the treatment of hypertension (Muntner et al, 2009; Vitry and Lai, 2009). These include inhibitors of angiotensin converting enzyme, angiotensin II type 1 (AT 1 ) receptor antagonists, and the more recently introduced direct renin inhibitors (Riccioni et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Angiotensin II Type 1 Receptors and Systemic Hemodynamic and Renal Responses to Stress and Altered Blood Volume in Conscious Rabbits

Xu¹,

Eppel²,

Head³

et al. 2011

Front. Physio.

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We examined how systemic blockade of type 1 angiotensin (AT1-) receptors affects reflex control of the circulation and the kidney. In conscious rabbits, the effects of candesartan on responses of systemic and renal hemodynamics and renal excretory function to acute hypoxia, mild hemorrhage, and plasma volume expansion were tested. Candesartan reduced resting mean arterial pressure (MAP, −8 ± 2%) without significantly altering cardiac output (CO), increased renal blood flow (RBF, +38 ± 9%) and reduced renal vascular resistance (RVR, −32 ± 6%). Glomerular filtration rate (GFR) was not significantly altered but sodium excretion (UNa+V) increased fourfold. After vehicle treatment, hypoxia (10% inspired O2 for 30 min) did not significantly alter MAP or CO, but reduced heart rate (HR, −17 ± 6%), increased RVR (+33 ± 16%) and reduced GFR (−46 ± 16%) and UNa+V (−41 ± 17%). Candesartan did not significantly alter these responses. After vehicle treatment, plasma volume expansion increased CO (+35 ± 7%), reduced total peripheral resistance (TPR, −26 ± 5%), increased RBF (+62 ± 23%) and reduced RVR (−32 ± 9%), but did not significantly alter MAP or HR. It also increased UNa+V (803 ± 184%) yet reduced GFR (−47 ± 9%). Candesartan did not significantly alter these responses. After vehicle treatment, mild hemorrhage did not significantly alter MAP but increased HR (+16 ± 3%), reduced CO (−16 ± 4%) and RBF (−18 ± 6%), increased TPR (+18 ± 4%) and tended to increase RVR (+18 ± 9%, P = 0.1), but had little effect on GFR or UNa+V. But after candesartan treatment MAP fell during hemorrhage (−19 ± 1%), while neither TPR nor RVR increased, and GFR (−64 ± 18%) and UNa+V (−83 ± 10%) fell. AT1-receptor activation supports MAP and GFR during hypovolemia. But AT1-receptors appear to play little role in the renal vasoconstriction, hypofiltration, and antinatriuresis accompanying hypoxia, or the systemic and renal vasodilatation and natriuresis accompanying plasma volume expansion.

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Section: Introductionmentioning

confidence: 99%

Angiotensin II Type 1 Receptors and Systemic Hemodynamic and Renal Responses to Stress and Altered Blood Volume in Conscious Rabbits

Xu¹,

Eppel²,

Head³

et al. 2011

Front. Physio.

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“…From 2006 to 2007 there was a substantial increase in use of antihypertensive medicines in Serbia which is comparable to the increase in the referential countries [1,5,9]. In the observed period there was a trend of increase in cardiovascular pharmacotherapy educations for general practitioners, as well as an increasing number of regional representatives of pharmaceutical companies for Niš region (Figure 3 special emphasis on national and international guidelines as well as on the rational treatment of hypertension.…”

Section: Discussionmentioning

confidence: 69%

“…In modern clinical practice, analyzing drug utilization is an important tool for achieving rational drug therapy in any clinical setting [9][10][11][12]. It is necessary for identification of a problem, and for following effectiveness of corrective interventions, undertaken by management of a health facility.…”

Section: Discussionmentioning

confidence: 99%

“…Prescription sales of antihypertensive drugs in Australia between1993-2002 are correlated with promotional advertising and market shares. Drug promotion is one of the main factors that influence prescribing practice, but there are limited data available to quantify the relationship between drug advertising and prescription sales [9]. Advertising trends in Australia were monitored by counting the annual number of advertisements published in medical journals with the highest circulation in Australia.…”

Section: Did -Defined Daily Doses Per 1000 Inhabitants/day * Consumptmentioning

confidence: 99%

“…Furthermore, marketing and drug promotion by pharmaceutical companies have been identified as one of the main factors that influence prescribing practices. However, there are only few published quantitative studies, which have examined the relationship between marketing of pharmaceutical drugs and the use of antihypertensive drugs [9].…”

Section: Introductionmentioning

confidence: 99%

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Antihypertensive drugs utilisation and educational activities

Veličković‐Radovanović¹,

Petrović²,

Kodela

et al. 2010

Open Medicine

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AbstractThe mortality rate from cardiovascular diseases is high in Serbia. Analysis of antihypertensive drugs utilization is the basis for assessment of cardiovascular pharmacotherapy appropriateness. The aim of this study was to analyze the trend in antihypertensive drugs utilization among outpatients in Niš region, South Serbia compared to some Nordic countries (Norvay, Sweden) and Australia as well as to analyze trends in educational and drug promotion activities directed to primary healthcare workers within the same region. Using the ATC/DDD methodology, we analyzed the utilization of antihypertensive drugs dispensed on prescription in the Nis region over the 2003–2007 period. The study was retrospective, based on data obtained from Central City Pharmacy Nis. Educational and drug promotion activities were noted from the records of Medical Faculty, University of Nis, and from the records of local branches of pharmaceutical companies active in Serbia. Wilcoxon’s test was used in order to calculate the statistical significance of difference. A significant increase of 79.8% (153.8/ 276.6 DDD/inhabitants/day) in antihypertensive drug consumption was observed in the same period. This analysis showed there were substantial increases in the use of diuretics (134.7%), ACE inhibitors (79.5%) and calcium channel blockers (116.1%), especially amlodipin (241.2%). During the observed period, annual numbers of educational activities and of pharmaceutical sales representatives employed within the region increased for almost one fourth. This analysis pointed to a significant increase in the use of antihypertensive drugs in the Nis region, which was matched with increase in educational and drug promotion activities within the region, so that in 2006–2007 total consumption was approximate to some referential countries (Norvay, Sweden).

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Advertising and Marketing

Belsey¹

2010

Principles and Practice of Pharmaceutical Medicine

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Advertising of antihypertensive medicines and prescription sales in Australia

Abstract: Prescription sales of antihypertensives in Australia are correlated with promotional advertising. The newest and most expensive medicines may be chosen over older effective drugs by prescribers. New policies on drug promotion control need to be developed.

Cited by 6 publications

References 9 publications

Angiotensin II Type 1 Receptors and Systemic Hemodynamic and Renal Responses to Stress and Altered Blood Volume in Conscious Rabbits

Angiotensin II Type 1 Receptors and Systemic Hemodynamic and Renal Responses to Stress and Altered Blood Volume in Conscious Rabbits

Antihypertensive drugs utilisation and educational activities

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