Adverse reactions to radiocontrast media in an Indian population.

Thomas, Molly; Peedicayil, Jacob; Koshi, Takana; Korah, Ipeson

doi:10.1259/bjr.72.859.10624321

Cited by 20 publications

(16 citation statements)

References 16 publications

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“…15 In contrast to some published reports, we observed no relationship between the incidence of adverse events and the dose of iodine administered. 16 Cochran et al speculated that contrast dose might play a role in the incidence of reactions, because 70% of severe reactions occurred in patients receiving higher iodine doses for computed tomography (CT) angiography. However, Cochran et al were unaware of the exact number of CT examinations performed using a higher contrast dose; therefore, this speculation may be based on a statistical quirk.…”

Section: Discussionmentioning

confidence: 99%

A study on adverse drug reactions to non-ionic contrast medium in an Indian population: a 1-year experience

Bhowmick

Bhat

Panja

et al. 2014

Int J Basic Clin Pharmacol

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Background: To the best of our understanding, very few studies focusing on the adverse drug reaction (ADR) profile of non-ionic contrast medium (NICM) has been carried out until date among the Indian population. Hence, this study was planned. We sincerely believe that the knowledge gathered from this study can improve safer usage of these agents among the patients of Indian origin. The objective was to evaluate the incidence and severity of ADRs of non-ionic radio contrast media (CM) used in tertiary care hospital in Eastern India. Methods: For the duration of 1-year from July 2011 to July 2012, we prospectively recorded all the ADRs associated with the administration of NICM (iohexol and ioversol) in 3708 patients of Indian origin undergoing computed tomography scan at the hospital. The average median age, weight, dose used; types of ADRs, concomitant medication, final diagnosis, reasons for use were recorded and analyzed with appropriate statistical tools. Causality assessment was performed using Naranjo scale. Results: Eleven of 3708 patients who received either ioversol or iohexol developed ADRs (i.e. 0.3% of patients). The most common ADR was rigor. The incidences of mild, moderate and severe reactions were 55%, 36% and 9%, respectively. Average median age, weight, and dose used were 35 years, 66 kg and 70 ml, respectively. All the ADRs were early (occurred within 1 hr of CM administration). Due to logical constraints, the follow-up of these patients was not possible and hence late ADRs were not captured. The common concomitant medication used was pantoprazole (63.63% of patients). The difference in the incidence of ADRs by age distribution (Group 1 -Iohexol, Group 2 -Ioversol) and weight distribution was not statistically significant (p=0.75 and p=0.18, respectively). Causality analysis revealed that all the ADRs were possible (Score of 4). Interestingly, the incidence of reactions was noted to be higher in patients with a history of gastro intestinal disorders (45.45%). Conclusions: This pilot study reveals that adverse reactions to NICM are rare and severe reactions are less common among the patients of Indian origin. However, a larger multicentric study across the country should be carried out to understand the safety profile of these CM better among the Indian population.

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Section: Discussionmentioning

confidence: 99%

A study on adverse drug reactions to non-ionic contrast medium in an Indian population: a 1-year experience

Bhowmick

Bhat

Panja

et al. 2014

Int J Basic Clin Pharmacol

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“…Previous studies reported no significant difference between genders in RCM hypersensitivity reactions [9, 10, 11]. Interestingly, a recent study conducted in Turkey (1,131 subjects), in Australia (29,962 subjects), and Thailand (55,286 subjects) showed that female gender was one of significant risk factors in RCM-induced hypersensitivity reactions [12] (Table 3).…”

Section: Clinical Manifestations and Risk Factorsmentioning

confidence: 92%

“…Although the prevalence of severe reactions varied depending on the studies, severe life-threatening reactions was 0.04-0.28% [1, 2, 4, 6, 7, 8, 9]. It has also been reported that RCM was the most responsible drug that accounted for 18.0% of in-hospital anaphylaxis in a Korean study conducted in a tertiary hospital [1].…”

Section: Clinical Manifestations and Risk Factorsmentioning

confidence: 99%

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Radiocontrast media hypersensitivity in the Asia Pacific region

Lee

Lim

Chang

2014

Asia Pacific Allergy

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Radiocontrast media (RCM) is a major cause of drug hypersensitivity reactions as the medical application of RCM is increasing recently. RCM induced hypersensitivity reactions are considered as unpredictable type B reactions. Underlying mechanism of RCM induced hypersensitivity was previously regarded as nonimmunological mechanisms but recent studies suggest that immunological mechanisms could also be involved. As a result, the roles of skin tests and premedication are revisiting. As there has been no report that comprehensively summarized and analyzed the results of the studies on RCM hypersensitivity in the Asia Pacific region, we aimed to review the literatures on hypersensitivity reactions to RCM in terms of prevalence clinical manifestations, diagnostic approach, and preventive measures in the Asia Pacific region.

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“…Mortele et al 26 observed eight cases (4%) of bronchospasm in a group of 211 patients with adverse events following the use of nonionic iodinated contrast medium for CT and 2.6% of bronchospasm after RCM has been reported in an Indian population 27 . Four (0.38%) asthmatic reactions have been described by Lira et al 28 during fluorescein angiography and, recently, two cases (0.18%) of bronchospasm have been found in children following the use of i.v.…”

Section: Introductionmentioning

confidence: 99%