Adverse reactions to nitrofurantoin

Holmberg, Leona; Boman, Gunnar; Böttiger, L. E.; Eriksson, B.; Spross, R.; Wessling, Ana

doi:10.1016/0002-9343(80)90443-x

Cited by 210 publications

(118 citation statements)

References 8 publications

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“…Similarly, acute reactions do not predispose to a chronic pattern. 2,10 Chronic NILD is thought to appear up to six months, or even years, after initiation of treatment. 1,6,9 It is thought to be due to direct toxicity, which, unlike acute hypersensitivity reactions, is dose-related.…”

Section: Discussion Acute Nitrofurantoin-induced Lung Disease (Nild)mentioning

confidence: 99%

“…1,6,9 It is thought to be due to direct toxicity, which, unlike acute hypersensitivity reactions, is dose-related. 2,11 It is most commonly seen in older women, likely due to their higher prevalence of UTIs, with a median age of 60 to 70 years. 2,3 It usually presents with an insidious onset of cough and progressive dyspnoea, although chest pain, myalgia, weight loss and fatigue may also occur.…”

Section: Discussion Acute Nitrofurantoin-induced Lung Disease (Nild)mentioning

confidence: 99%

“…2,11 It is most commonly seen in older women, likely due to their higher prevalence of UTIs, with a median age of 60 to 70 years. 2,3 It usually presents with an insidious onset of cough and progressive dyspnoea, although chest pain, myalgia, weight loss and fatigue may also occur. 11,12 Given the insidious onset, symptoms can be mistaken for more common causes such as heart failure.…”

Section: Discussion Acute Nitrofurantoin-induced Lung Disease (Nild)mentioning

confidence: 99%

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Nitrofurantoin-induced lung disease and prophylaxis of urinary tract infections

Madani

Mann

2012

Primary Care Respiratory Journal

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SummaryNitrofurantoin is commonly used for the treatment and prophylaxis of recurrent urinary tract infections (UTIs). Although relatively rare, nitrofurantoin is one of the commonest causes of drug-induced pulmonary disease, which can be potentially serious and even fatal. Knowledge of such potential adverse effects is essential to enable early recognition and withdrawal of the drug. Patients on long-term nitrofurantoin should be reviewed and monitored regularly. Management involves early consideration of the condition, and prompt withdrawal of the drug. We report three cases of nitrofurantoin-induced lung disease in patients who were on long-term nitrofurantoin for UTI prophylaxis and present a brief review of the literature on this subject.

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Section: Discussion Acute Nitrofurantoin-induced Lung Disease (Nild)mentioning

confidence: 99%

Section: Discussion Acute Nitrofurantoin-induced Lung Disease (Nild)mentioning

confidence: 99%

Section: Discussion Acute Nitrofurantoin-induced Lung Disease (Nild)mentioning

confidence: 99%

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Nitrofurantoin-induced lung disease and prophylaxis of urinary tract infections

Madani

Mann

2012

Primary Care Respiratory Journal

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“…The most common adverse events associated with NF include nausea, headache, and fl atulence (4). Although rare, serious adverse events in patients receiving long-term (>6 months), low-dose NF prophylaxis have also been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Although rare, serious adverse events in patients receiving long-term (>6 months), low-dose NF prophylaxis have also been reported. These include chronic pulmonary reactions, hepatic injury, peripheral neuropathy, and hypersensitivity to NF (4,(8)(9)(10)(11)(12). Here we report the case of acute liver damage caused by administration of NF.…”

Section: Discussionmentioning

confidence: 99%

Nitrofurantoin-Induced Acute Liver Damage in Pregnancy

Akšamija¹,

Horvat²,

Habek³

et al. 2009

Archives of Industrial Hygiene and Toxicology

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This article presents a rare case of acute toxic hepatitis in thirty-one-year old primigravida. In the 36 th week of gestation, the patient was introduced nitrofurantoin 100 mg a day due to symptoms of dysuria and enterococcus isolated from urine culture. After induced delivery at term because of hypertension, repeated laboratory fi ndings showed increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and negative hepatitis C and B markers. The patient was subicteric at the time. Coagulation and complete blood count values were within the normal range. Nitrofurantoin therapy was discontinued. Abdominal ultrasound was normal with the exception of a slight hepatomegaly without any lesions, focal or diffuse. Given that discontinuation of nitrofurantoin and introduction of methylprednisolon therapy signifi cantly lowered liver enzyme levels, restoring most of them to normal, we concluded that this was probably the case of toxic liver damage caused by nitrofurantoin.

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Nitrofurantoin Unmasking Peripheral Neuropathy in a Type 2 Diabetic Patient

White¹

1984

Arch Intern Med

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Adverse reactions to nitrofurantoin

Cited by 210 publications

References 8 publications

Nitrofurantoin-induced lung disease and prophylaxis of urinary tract infections

Nitrofurantoin-induced lung disease and prophylaxis of urinary tract infections

Nitrofurantoin-Induced Acute Liver Damage in Pregnancy

Nitrofurantoin Unmasking Peripheral Neuropathy in a Type 2 Diabetic Patient

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