Adverse reactions to Mycobacterium bovis bacille Calmette–Guérin (BCG) vaccination against tuberculosis in humans, veterinary animals and wildlife species

Murphy, David; Corner, L. A.; Gormley, Eamonn

doi:10.1016/j.tube.2007.11.010

Cited by 56 publications

(46 citation statements)

References 84 publications

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“…The genes differentially downregulated in infected wild boar were selected to investigate the 5 host response to BCG immunization. Vaccination with BCG did not produce adverse reactions in wild boar as it has been reported in humans and domestic and wild animals (Murphy et al, 2008). Total RNA was extracted from PBMC of seven BCG-immunized and seven non-immunized control animals and used for transcriptional profiling.…”

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confidence: 92%

Expression of immunoregulatory genes in peripheral blood mononuclear cells of European wild boar immunized with BCG

Lastra

Galindo

Gortázar

et al. 2009

Veterinary Microbiology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1

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confidence: 92%

Expression of immunoregulatory genes in peripheral blood mononuclear cells of European wild boar immunized with BCG

Lastra

Galindo

Gortázar

et al. 2009

Veterinary Microbiology

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“…Although reports of adverse reactions arising from the use of BCG are relatively uncommon (11), there are many factors believed to cause side effects (12), such as the substrain (12,13) and route of administration (11,(13)(14)(15)(16). In wildlife and domestic animals, although several species have been vaccinated by different routes (11,17), no adverse reactions other than local reactions in badgers and some systemic reactions in cattle have been reported (11,18).…”

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confidence: 99%

“…In wildlife and domestic animals, although several species have been vaccinated by different routes (11,17), no adverse reactions other than local reactions in badgers and some systemic reactions in cattle have been reported (11,18). In the case of the badgers, differences in the persistence of the lesions were also dependent on the strain and the route of administration (11,18). In cattle, adverse effects have been attributed to high doses used for vaccination (10 9 CFU) and to contamination of the BCG preparation (11).…”

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confidence: 99%

Assessment of an Oral Mycobacterium bovis BCG Vaccine and an Inactivated M. bovis Preparation for Wild Boar in Terms of Adverse Reactions, Vaccine Strain Survival, and Uptake by Nontarget Species

Beltrán‐Beck

Romero

Sevilla

et al. 2013

Clin. Vaccine Immunol.

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Wildlife vaccination is increasingly being considered as an option for tuberculosis control. We combined data from laboratory trials and an ongoing field trial to assess the risk of an oral Mycobacterium bovis BCG vaccine and a prototype heat-inactivated Mycobacterium bovis preparation for Eurasian wild boar (Sus scrofa). We studied adverse reactions, BCG survival, BCG excretion, and bait uptake by nontarget species. No adverse reactions were observed after administration of BCG (n ‫؍‬ 27) or inactivated M. bovis (n ‫؍‬ 21). BCG was not found at necropsy (175 to 300 days postvaccination [n ‫؍‬ 27]). No BCG excretion was detected in fecal samples (n ‫؍‬ 162) or in urine or nasal, oral, or fecal swab samples at 258 days postvaccination (n ‫؍‬ 29). In the field, we found no evidence of loss of BCG viability in baits collected after 36 h (temperature range, 11°C to 41°C). Camera trapping showed that wild boar (39%) and birds (56%) were the most frequent visitors to bait stations (selective feeders). Wild boar activity patterns were nocturnal, while diurnal activities were recorded for all bird species. We found large proportions of chewed capsules (29%) (likely ingestion of the vaccine) and lost baits (39%) (presumably consumed), and the proportion of chewed capsules showed a positive correlation with the presence of wild boar. Both results suggest proper bait consumption (68%). These results indicate that BCG vaccination in wild boar is safe and that, while bait consumption by other species is possible, this can be minimized by using selective cages and strict timing of bait deployment.

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“…9 Such infants had twice the incidence of lymphadenitis as those vaccinated at >3 months of age. 10 Diagnosis of BCG lymphadenitis is usually made on clinical ground. Small lymph node enlargement occurs as a natural process after vaccination and not considered as complication.…”

Section: Case Reportmentioning

confidence: 99%

BCG lymphadenitis of a healthy infant

Mohamed

Zaini

Rahman

2016

Bangladesh J Med Sci

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Abstract:This is a case of a 2-month-old infant who had suppurative lymphadenitis at left axilla after Bacille Calmette Guérin (BCG) vaccination. She presented with a non-healing BCG wound and left axillary swelling associated with one-week fever at 2 months of age. Aspiration under general anaesthesia was done and pus sent for mycobacterium culture grew Mycobacterium tuberculosis complex. The patient improved without anti-tuberculosis treatment.

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Adverse reactions to Mycobacterium bovis bacille Calmette–Guérin (BCG) vaccination against tuberculosis in humans, veterinary animals and wildlife species

Cited by 56 publications

References 84 publications

Expression of immunoregulatory genes in peripheral blood mononuclear cells of European wild boar immunized with BCG

Expression of immunoregulatory genes in peripheral blood mononuclear cells of European wild boar immunized with BCG

Assessment of an Oral Mycobacterium bovis BCG Vaccine and an Inactivated M. bovis Preparation for Wild Boar in Terms of Adverse Reactions, Vaccine Strain Survival, and Uptake by Nontarget Species

BCG lymphadenitis of a healthy infant

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