Adverse Reactions to Antituberculosis Drugs in Iranian Tuberculosis Patients

Abstract

Background. Antituberculosis multidrug regimens have been associated with increased incidence of adverse drug reactions (ADRs). This study aimed to determine the incidence and associated factors of ADRs due to antituberculosis therapy. Methods. This is a retrospective cross-sectional study on tuberculosis patients who were treated in tuberculosis clinics in Markazi province in Iran. The information contained in the medical files was extracted and entered into the questionnaire. Data was descriptively analyzed by using statistical package for social sciences (SPSS 18). Results. A total of 940 TB patients of 1240 patients' medical records available in 10 medical offices were included in this study. Of the 563 ADRs found in this study, 82.4% were considered minor reactions and 17.6% were major reactions. No death from antituberculosis ADR was observed. We found that the risk of major ADRs was higher in females (P value = 0.0241), age >50 y (P value = 0.0223), coinfection with HIV (P value = 0.0323), smoking (P value = 0.002), retreatment TB (P value = 0.0203), and comorbidities (P value = 0.0005). Conclusions. This study showed that severe side effects of anti-TB drugs are common in patients who have risk factors of ADRs and they should be followed up by close monitoring.

A prospective pharmacovigilance study to evaluate adverse effect profile of first line anti-tubercular drugs in newly diagnosed sputum positive patients

“…Similar such results were reported by few earlier researchers (Table 1). 14,17 In the present study, the haematological factors were significantly affected. Amongst the haematological parameters Hb% was reduced significantly (p<0.01), other parameters such as ESR, TLC, Platelet count and PTINR though affected significantly but they were within normal limits.…”

Clinical epidemiology and treatment findings of acute tuberculosis patients in Babol City (2009–2013)

“…In study of Farazi et al, acute side effects and mild side effects were observed in 17.6% and 82.4% of the patients, respectively [31] . A study of Ayatollahi and Khavandegaran in Shiraz City, Iran reported that 29.5% of TB patients had mild and 5.2% had acute drug adverse effects [32] .…”

“…Since high costs of TB treatment are usually imposed on families during the first 2-3 months, this may lead to the reduction in the quality of their lives [30] . There are many factors causing treatment delay and treatment failure including lack of compliance to the treatment protocol, improper nutrition during treatment, wrong treatment regimen, delayed treatment, problems in drug distribution, lack of timely supervision and correct advice on the way of taking drugs [27,31] . According to the mentioned points, the treatment status in cured and completed treatment group in Babol City is better than that has been reported in other studies.…”

Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial

“…During treatment with anti‐TB drugs, up to 83.5% of patients may experience ADRs (Maciel et al ., ). Gastrointestinal (22%) and hepatobiliary symptoms (35.7%) were the most common anti‐TB induced ADRs (Farazi et al ., ). From the conventional first line anti‐TB drugs, isoniazid (INH), rifampin (RIF), and pyrazinamide (PZA) are potential hepatotoxic agents (Tostmann et al ., ).…”