Adverse reactions to alcohol and alcoholic beverages

Segmental urticaria triggered by alcohol consumption

“…The acute and chronic toxicologic effects after alcohol misuse are well known. 5 Less known adverse reactions to alcohol use, including urticaria, have been the subject of a recent study 6 nonimmunologic reactions. Specifically, 3 mechanisms were proposed with regard to urticarial reactions to alcohol: (1) the direct action of ethanol on mast cells causing them to degranulate, (2) allergenic potential of ethanol metabolites, and (3) the activation of prostaglandin and endogenous opioid receptors.…”

Mast Cell Activation Disease and Microbiotic Interactions

“…51 Chronic alcohol consumption modifies human gut microbiota, causing endotoxemia and immune system hyperactivation, which contribute to liver disease 52 and are all the more interesting in view of the frequency of hepatic abnormalities in MCAS. 53 Alcohol has complex effects on MCs: Alcohol-related immunosuppression may be due in part to MC inhibition 54 and even apoptosis 15 by alcohol (or its metabolites), but in some circumstances alcohol and its metabolites (or preservatives such as sulfites) activate MCs, [55][56][57] which may be unsurprising given the intolerance that many patients with MCAD have for alcohol. 58,59 Dietary management is important in IBS.…”

Enfoque diagnóstico del paciente con rubor facial transitorio en atención primaria

“…El diagnóstico de anafilaxia es muy probable cuando se cumple cualquiera de los tres criterios (tabla 4) (25). Las pruebas de laboratorio respaldan el diagnóstico clínico; pero resultados normales no lo descartan (25). Las principales pruebas indicadas en la literatura son las concentraciones de triptasa sérica e histamina sérica elevadas, tomadas de forma inmediata en el servicio de urgencias, por lo que su disponibilidad se limita al contexto hospitalario (25).…”