Adverse reactions following fazadinium‐thiopentone induction

Alexander, J.P.

doi:10.1111/j.1365-2044.1979.tb06367.x

Cited by 10 publications

(2 citation statements)

References 28 publications

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“…Until recently, allergy to cisatracurium was not thought to exist. Instead, confirmed cases of anaphylactoid response to thiopentone have been recorded in the literature ( 8). In a recent study, thiopentone was associated with histamine release, although only cisatracurium‐treated patients had increased histamine levels > 1 ng·ml −1 , thus implicating the muscle relaxant as the cause of these increases ( 9).…”

Section: Discussionmentioning

confidence: 98%

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Persistent anaphylactic reaction after induction with thiopentone and cisatracurium

Briassoulis

Hatzis

Mammi

et al. 2000

Pediatric Anesthesia

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A 6-year-old boy presented for surgery for phimosis. The anaesthetic technique included intravenous induction with thiopentone and neuromuscular blockade with cisatracurium. Severe persistent bronchospasm and central cyanosis followed the administration of these drugs. A continuous i.v. infusion of epinephrine at 0.2 microg. kg(-1) x min(-1) was necessary to break the severe refractory bronchial hyperresponsiveness. There was no previous exposure to anaesthetic drugs and no definite family history of allergy. Through increased serum eosinophil cationic protein, tryptase and histamine levels and IgE levels specific to cisatracurium, we demonstrated an IgE-mediated anaphylactic reaction to cisatracurium in the child's first exposure to this new neuromuscular blocking agent. Anaphylactic reactions to new anaesthetic drugs may be challenging to recognize and treat during general anaesthesia in children. The pathogenesis, diagnosis and management of life threatening persistent allergic reactions to intravenous anaesthetics are discussed.

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Section: Discussionmentioning

confidence: 98%

“…The course of severe anaphylactoid accidents during anaesthesia is not always favourable ( 8). Experimental data suggests that the protective effect of aminophylline on histamine reactivity results from the release of endogenous catecholamines during thiopentone anaesthesia ( 19).…”

Section: Discussionmentioning

confidence: 99%