Adverse reactions and interactions limiting the use of antihypertensive drugs

Nies, Alan S.

doi:10.1016/0002-9343(75)90122-9

Cited by 53 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…'~3 The adverse effects of antihypertensive medications also have been well documented. 6 ' 7 While high blood pressure can be safely treated in most individuals, side effects of drugs are relatively frequent and may have notable effects on quality of life and compliance with the prescribed regimens.…”

mentioning

confidence: 99%

Antihypertensive drug side effects in the Hypertension Detection and Follow-up Program.

et al. 1988

View full text Add to dashboard Cite

The 5485 participants in the Hypertension Detection and Follow-up Program, Stepped-Care group form one of the largest groups to date on which detailed surveillance of long-term antihypertensive therapy and drug side effects has been reported. During a 5-year period, among all hypertensive persons (mild, moderate, and severe combined) who were not taking antihypertensive medications at the beginning of the study and who attended the clinic at least once during the 5-year trial, a total of 9.3% had definite or probable side effects severe enough to cause discontinuation of the drug treatment in question. Less than 1% of active participants required hospitalization for side effects. No death that could be attributed to side effects was detected. Thus, the Hypertension Detection and Follow-up Program data, which have previously demonstrated the beneficial effects of antihypertensive therapy, confirm the relative safety of such therapy.

show abstract

mentioning

confidence: 99%

Antihypertensive drug side effects in the Hypertension Detection and Follow-up Program.

et al. 1988

View full text Add to dashboard Cite

show abstract

“…In one major review of the side effects of the drug, bradycardia was not even mentioned. 10 Blanshard et al u reported bradycardia in only one out of 65 patients, and in an extensive comparison of guanethidine with other antihypertensive agents, Prichard et al…”

Section: Discussionmentioning

confidence: 99%

Symptomatic sick sinus syndrome due to guanethidine. Case report.

Rowe¹,

Bassan²

1979

Hypertension

View full text Add to dashboard Cite

1959 as an antihypertensive agent, 1 there have been numerous reports of its side effects, and it has been recommended that the drug be used only in severe hypertension when treatment with other drugs has failed. 5 ' 3 More recent reports, however, have called attention to the outstanding absence of significant toxic or allergic effects attributable to guanethidine, and have also challenged the common belief that treatment of moderate hypertension with the drug is accompanied by an intolerably high incidence of side effects. Mild to moderate sinus bradycardia, not requiring drug discontinuation, has been well documented as a not infrequent side effect of guanethidine. 8 " 9 We wish to report the case of a patient receiving guanethidine who developed episodes of dizziness and blurred vision due to severe sinus bradycardia with episodes of prolonged sinus arrest. These phenomena disappeared with discontinuation of guanethidine and reappeared upon challenge with the drug. Sinus node dysfunction, in such an extreme form, has not previously been so conclusively related to guanethidine.Case Report A 65-year-old man was admitted to the hospital following an episode of weakness, dizziness, and blurred vision. He had never experienced such symptoms previously. He was known to be hypertensive for at least 8 years, and had suffered a myocardial infarction 4 years prior to admission. His blood pressure had been treated initially with reserpine, then with alpha methyldopa, and finally, for the 12 months preceeding admission, with guanethidine, 75 mg once daily, and furosemide, 40 mg twice daily. He was not receiving any other medication.On examination the patient was quite obese (121 kg) and in no distress. Supine blood pressure was 150/90 with a pulse rate of 35 beats per minute (bpm) and slightly irregular. He was afebrile. The lungs were clear, the heart not palpably enlarged, and there were 543

show abstract

“…Furthermore, conditions of long du ration. complex treatment regimens, multiple conditions, and polypharmacy are all associ ated with non-compliance [47], All are rele vant to hypertension management and each has been shown to have an effect on com pliance [48][49][50], What is the link between qualitv-of-life assessment, therapeutic development and se lection. and improvement compliance?…”

Section: Implications For Compliancementioning

confidence: 99%

Role of Quality of Life in Hypertension Therapy: Implication for Patient Compliance

Turner¹

1992

Cardiology

View full text Add to dashboard Cite

Although the cardiovascular risk factors associated with hypertension are well established, the effects of the disease are usually transparent to the patient. However, the impact of diagnosis and treatment are often overt and usually negative. Because of high rates of non-compliance following adverse experiences with treatment, patients are exposed to the kind of risk for which therapeutic intervention was originally intended. The nature of the impact of hypertension therapy has become more clearly defined as well-controlled, quality-of-life studies have been reported across a variety of therapeutic classes. These studies may be used to address the problem of patient compliance by (1) informing the physician about the likely effects a class of, or particular, compound might have, and (2) by providing a means by which the physician can monitor and intervene in the treatment process. By using quality-of-life information, the clinician can directly influence the impact of therapy on the patient, improve compliance with the therapeutic regimen, and reduce that patient’s risk for cardiovascular events.

show abstract

Adverse reactions and interactions limiting the use of antihypertensive drugs

Cited by 53 publications

References 23 publications

Antihypertensive drug side effects in the Hypertension Detection and Follow-up Program.

Antihypertensive drug side effects in the Hypertension Detection and Follow-up Program.

Symptomatic sick sinus syndrome due to guanethidine. Case report.

Role of Quality of Life in Hypertension Therapy: Implication for Patient Compliance

Contact Info

Product

Resources

About