Adverse reaction to metal debris with accompanying gout and amyloid deposits in hip arthroplasty

Shah, Love; Zywiciel, Joseph; Kui, Alexander; Connor, Denton; Zhang, Cheryl; Picken, Maria M.; Allam, Emad

doi:10.1016/j.radcr.2022.11.079

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Shah et al 60 ) reported on the case of a 71-year-old male patient who underwent a metal-on-metal total hip arthroplasty procedure for treatment of osteoarthritis 13 years prior. The patient had MPO/p-ANCA-positive vasculitis and was on low-dose rituximab as a chronic medication.…”

Section: Literature Review Of Gout Associated With the Hip Jointmentioning

confidence: 99%

Pathophysiology and Treatment of Gout Arthritis; including Gout Arthritis of Hip Joint: A Literature Review

Cha,

Lee,

Choy

et al. 2024

Hip & Pelvis

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Gout is triggered by the accumulation of uric acid in the body, leading to hyperuricemia. Genetic, metabolic, and environmental factors can influence this condition. Excessive uric acid buildup results in the formation of monosodium urate (MSU) crystals, which precipitate in specific areas of the body, including the joints, where they can cause symptoms of gout. While the acute and chronic symptoms of gout have been well-documented, diagnosis of gout affecting the hip joint poses significant challenges. The global incidence of gout, the most prevalent form of inflammatory arthritis, is on the rise. Evaluation of the clinical signs, laboratory results, and imaging results is generally required for diagnosis of gout in cases where MSU crystals have not been detected. Hyperuricemia is considered a primary cause of arthritis symptoms, and comprehensive guidelines for treatment are available. Therefore, the choice of medication is straightforward, and moderate effectiveness of treatment has been demonstrated. Gout is a chronic disease, requiring lifelong uric acid-lowering medications, thus application of a treatment strategy based on the target blood uric acid concentration is necessary. Consequently, cases of gout will likely be observed more frequently by hip surgeons in clinical scenarios in the future. The objective of this review is to provide an overview of the pathophysiology of gout and subsequently examine recent advances in diagnostic methods and therapeutic agents based on an understanding of its underlying mechanisms. In addition, literature on gout-related issues affecting the hip joint, providing a useful reference for hip surgeons is examined.

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Section: Literature Review Of Gout Associated With the Hip Jointmentioning

confidence: 99%