Adverse reaction to bupivacaine

Authors’ Response

“…Benjamin states that allergic reactions to the amide class of local anesthetics are rare in comparison with the esters. Although his statement is true, there are many published reports that conclude that bupivacaine can cause allergic reactions (1–6). He further suggested that the patient did not have an allergic reaction to bupivacaine, but to one of the preservatives in the formulation.…”