Adverse psychological outcomes in long-term survivors of hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study (BMTSS)

Sun, Can Lan; Francisco, Liton; Baker, K. Scott; Weisdorf, Daniel J.; Forman, Stephen J.; Bhatia, Smita

doi:10.1182/blood-2011-04-348730

Cited by 131 publications

(125 citation statements)

References 46 publications

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“…The latter finding was rather unexpected as other studies suggested the level of distress to decline over time following transplantation. 13 In contrast to our findings Sun and co-workers 35 described a twofold increase in somatic distress levels in patients with active chronic GvHD as compared with a group of healthy siblings in more than thousand long-term survivors of HSCT. Our group of consecutively interviewed patients was rather heterogeneous with respect to the underlying diseases and stages and standard transplant variables.…”

Section: Discussioncontrasting

confidence: 55%

High prevalence of distress in patients after allogeneic hematopoietic SCT: Fear of progression is associated with a younger age

Hefner

Kapp

Drebinger

et al. 2014

Bone Marrow Transplant

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Little is known about the psychological burden patients are left with after successful allogeneic hematopoietic SCT (HSCT). With the main focus on physical condition and common transplant complications, psychological symptoms often remain neglected in daily practice. To assess the prevalence of distress in patients who have undergone allogeneic HSCT, we conducted a cross-sectional pilot study in 50 consecutive patients from our outpatient transplant clinic using standardized questionnaires. Distress was categorized by symptoms of anxiety, fear of progression, depression and post-traumatic stress disorder (PTSD). Forty-one patients completed self-administered questionnaires. The median age was 53 years (21-74 years) and the mean time after transplantation was 614 days (25-2070 days). In total, 18 patients (44%) showed symptoms of distress. Among these 18 patients, 11 patients reported symptoms of anxiety, 12 patients suffered from fear of progression, 11 patients showed symptoms of depression and 6 patients of PTSD. Age below 55 years was significantly associated with fear of progression (P ¼ 0.004). This study demonstrates the high prevalence of distress in patients who have undergone allogeneic HSCT. Our results suggest an unmet need for professional support and intervention. These findings may be relevant as distress could have an influence on the outcome after HSCT.

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Section: Discussioncontrasting

confidence: 55%

High prevalence of distress in patients after allogeneic hematopoietic SCT: Fear of progression is associated with a younger age

Hefner

Kapp

Drebinger

et al. 2014

Bone Marrow Transplant

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“…40, 41 Clinical depression is reported in 9% to 20% of long-term survivors. [42][43][44][45] Those more vulnerable to emotional difficulties long term after HCT include survivors with more traumatic transplantation experience, less than college education, lower income, and poorer mental health before HCT.…”

Section: Psychological Adjustmentmentioning

confidence: 99%

Delivering Care to Long-Term Adult Survivors of Hematopoietic Cell Transplantation

Syrjala

Martin

Lee

2012

JCO

102

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A B S T R A C TThis review highlights long-term and late consequences of hematopoietic cell transplantation (HCT) as well as strategies to manage or prevent complications that are more prevalent after HCT than most other cancer treatments. Chronic graft-versus-host disease stands out as a unique late effect of allogeneic HCT that is not seen after other types of cancer treatment. However, many other complications seen after solid tumor treatments are also common after HCT, including infections, second cancers, bone loss, and cardiovascular, pulmonary, renal, and endocrine dysfunction. Symptoms and syndromes that are reported after HCT include sexual dysfunction, cognitive problems, fatigue, insomnia, musculoskeletal symptoms, emotional distress, anger, and depression. Addressing these complex potential or actual complications requires diligent routine health care to intervene early or, when possible, to prevent late complications. To accomplish early detection and prevention of life-threatening complications, HCT survivors should undergo an annual comprehensive physical examination that includes screening for functional and psychosocial consequences of treatment and encouraging healthy lifestyle behaviors. Clinicians can link survivors to numerous online, print, and video resources to help them advocate for their health needs.

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“…In addition to causing systemic tissue damage, GVHD has also been associated with significant impairments in overall quality of life (12,13). Depression, anxiety, and mood alterations have been commonly reported in patients who develop this disease (14,15).…”

Section: Introductionmentioning

confidence: 99%

Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD

Belle¹,

Zhou²,

Stuhr³

et al. 2017

JCI Insight

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Adverse psychological outcomes in long-term survivors of hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study (BMTSS)

Cited by 131 publications

References 46 publications

High prevalence of distress in patients after allogeneic hematopoietic SCT: Fear of progression is associated with a younger age

High prevalence of distress in patients after allogeneic hematopoietic SCT: Fear of progression is associated with a younger age

Delivering Care to Long-Term Adult Survivors of Hematopoietic Cell Transplantation

Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD

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