Adverse Pregnancy Outcomes and<i>Coxiella burnetii</i>Antibodies in Pregnant Women, Denmark

Nielsen, Stine Yde; Mølbak, Kåre; Henriksen, Tine Brink; Krogfelt, Karen A.; Larsen, Carsten Schade; Villumsen, Steen

doi:10.3201/eid2006.130584

Cited by 25 publications

(20 citation statements)

References 22 publications

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“…33,34 A recently published study in Denmark 35 and a study that we published recently collecting all the data available in the literature in a meta-analysis 36 confirm that Q fever occurring during pregnancy is associated with a risk of miscarriage. The risk of miscarriage is highest in the first trimester, with a risk of fetal growth retardation, fetal malformations and prematurity occurring later.…”

Section: Q Fever During Pregnancysupporting

confidence: 53%

Recent advances in the study of Q fever epidemiology, diagnosis and management

Million

Raoult

2015

Journal of Infection

112

110

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Section: Q Fever During Pregnancysupporting

confidence: 53%

Recent advances in the study of Q fever epidemiology, diagnosis and management

Million

Raoult

2015

Journal of Infection

112

110

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“…To avoid these severe complications, we recommend treatment with co-trimoxazole until the eighth month of pregnancy (164). A recent Danish study confirmed such associations, with 47% of pregnant women seropositive for C. burnetii presenting obstetrical complications (miscarriage, preterm delivery, small infant for gestational age, oligohydramnios, fetal growth restriction, or perinatal death) (313). Interestingly, previous large case-control studies in the same country using serological markers of past C. burnetii infection in pregnant women failed to detect an association with obstetrical complications (429,430).…”

Section: Clinical Aspects Chronic Q Fever: From Historical Backgroundmentioning

confidence: 99%

“…IL-10 is upregulated during pregnancy, whereas TNF and IL-1 are increased after parturition (312). In women, there is some evidence that the immune response is silenced and antibodies are produced in response to infection (313). This might be related to IL-10 production, which may account for the increased risk of endocarditis after delivery.…”

Section: Role Of the Hostmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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“…Infection during pregnancy is a risk for the women to develop chronic Q fever later; however, the major concern is pregnant women with Q fever are at higher risk of miscarriage/stillbirth, premature parturition and intrauterine fetal growth retardation and should receive prompt medical treatment to avoid adverse outcomes …”

Section: Zoonotic Risks and Mitigation Strategiesmentioning

confidence: 99%

Management of Coxiella burnetii infection in livestock populations and the associated zoonotic risk: A consensus statement

Plummer

McClure

Menzies

et al. 2018

Veterinary Internal Medicne

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Infections caused by Coxiella burnetii, commonly referred to as coxiellosis when occurring in animals and Query fever when occurring in humans, are an important cause of abortions, decreased reproductive efficiency, and subclinical infections in ruminants. The organism also represents an important zoonotic concern associated with its ability to aerosolize easily and its low infectious dose. Available diagnostic tests have limited sensitivity, which combined with the absence of treatment options in animals and limited approaches to prevention, result in difficulty managing this agent for optimal animal health and zoonotic disease outcomes. The purpose of this consensus statement is to provide veterinarians and public health officials with a summary of the available information regarding management of C. burnetii infection in livestock populations. A discussion of currently available testing options and their interpretation is provided, along with recommendations on management practices that can be implemented on‐farm in the face of an outbreak to mitigate losses. Emphasis is placed on biosecurity measures that can be considered for minimizing the zoonotic transmission risk in both field and veterinary facilities.

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Adverse Pregnancy Outcomes andCoxiella burnetiiAntibodies in Pregnant Women, Denmark

Abstract: Q fever may be associated with complications, but overall risk is low.

Cited by 25 publications

References 22 publications

Recent advances in the study of Q fever epidemiology, diagnosis and management

Recent advances in the study of Q fever epidemiology, diagnosis and management

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

Management of Coxiella burnetii infection in livestock populations and the associated zoonotic risk: A consensus statement

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